Systems & Computational Biology
Co-existing feedback loops generate tissue-specific circadian rhythmsThe analysis of tissue-specific data-based models of the gene regulatory network of the mammalian circadian clock reveals organ-specific synergies of feedback loops.
Multi-region proteome analysis quantifies spatial heterogeneity of prostate tissue biomarkersApplication of pressure cycling technology and Sequential Windowed Acquisition of all THeoretical mass spectrometry allows quantifying the degree of intra-tumor heterogeneity of protein expression in prostate tumors. The data show that protein intra-tumor heterogeneity, if not characterized, may distort protein biomarker suitability in tumor tissues.
Pervasive allele-specific regulation on RNA decay in hybrid miceUsing a F1 hybrid mouse system, this study globally investigates the effects of cis-regulatory divergence on RNA decay in mammals and reveals the evolutionary roles of RNA decay regulation.