Synthetic Biology
- Sufficiency analysis of estrogen responsive enhancers using synthetic activators
Enhancers bound by synthetic activators can recreate a transcriptional response to estrogen, drive different levels of gene expression, and work independently to regulate transcription.
- Expanding the repertoire of glucocorticoid receptor target genes by engineering genomic response elements
This study shows that addition of a single transcription factor binding site can be sufficient to convert a gene into a glucocorticoid receptor target.