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Synthetic Biology

  • Sufficiency analysis of estrogen responsive enhancers using synthetic activators
    Open Access
    Sufficiency analysis of estrogen responsive enhancers using synthetic activators

    Matthew Ginley-Hidinger, Julia B Carleton, Adriana C Rodriguez, Kristofer C Berrett, Jason Gertz

    Matthew Ginley-Hidinger ... Jason Gertz

    Published 30 September 2019

    Enhancers bound by synthetic activators can recreate a transcriptional response to estrogen, drive different levels of gene expression, and work independently to regulate transcription.

  • Expanding the repertoire of glucocorticoid receptor target genes by engineering genomic response elements
    Open Access
    Expanding the repertoire of glucocorticoid receptor target genes by engineering genomic response elements

    Verena Thormann, Laura V Glaser, Maika C Rothkegel, Marina Borschiwer, Melissa Bothe, Alisa Fuchs, Sebastiaan H Meijsing

    Verena Thormann ... Sebastiaan H Meijsing

    Published 13 March 2019

    This study shows that addition of a single transcription factor binding site can be sufficient to convert a gene into a glucocorticoid receptor target.

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