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Structural Biology

  • Structural basis of guanine nucleotide exchange for Rab11 by SH3BP5
    Open Access
    Structural basis of guanine nucleotide exchange for Rab11 by SH3BP5

    Sakurako Goto-Ito, Nobukatsu Morooka, Atsushi Yamagata, Yusuke Sato, Ken Sato, Shuya Fukai

    Sakurako Goto-Ito ... Shuya Fukai

    Published 14 March 2019

    The structure of the SH3BP5–Rab11a complex and structure-based mutational analyses reveal structural basis of nucleotide exchange for Rab11 by its specific guanine nucleotide exchange factor.

  • Folding–function relationship of the most common cystic fibrosis–causing CFTR conductance mutants
    Open Access
    Folding–function relationship of the most common cystic fibrosis–causing CFTR conductance mutants

    Marcel van Willigen, Annelotte M Vonk, Hui Ying Yeoh, Evelien Kruisselbrink, Bertrand Kleizen, Cornelis K van der Ent, Maarten R Egmond, Hugo R de Jonge, Ineke Braakman, Jeffrey M Beekman, Peter van der Sluijs

    Marcel van Willigen ... Peter van der Sluijs

    Published 18 January 2019

    The tight correlation between folding and function in cystic fibrosis patients with CFTR mutations of the altered-conductance CFTR class provides an attractive paradigm for characterizing mode of action of novel therapeutics.

  • The crystal structure of Staufen1 in complex with a physiological RNA sheds light on substrate selectivity
    Open Access
    The crystal structure of Staufen1 in complex with a physiological RNA sheds light on substrate selectivity

    Daniela Lazzaretti, Lina Bandholz-Cajamarca, Christiane Emmerich, Kristina Schaaf, Claire Basquin, Uwe Irion, Fulvia Bono

    Daniela Lazzaretti ... Fulvia Bono

    Published 18 October 2018

    Combination of in vitro and in vivo data show that RNA sequence influences Staufen target recognition and that protein–RNA base contacts are required for Staufen function in Drosophila.

  • Specificity for deubiquitination of monoubiquitinated FANCD2 is driven by the N-terminus of USP1
    Open Access
    Specificity for deubiquitination of monoubiquitinated FANCD2 is driven by the N-terminus of USP1

    Connor Arkinson, Viduth K Chaugule, Rachel Toth, Helen Walden

    Connor Arkinson ... Helen Walden

    Published 12 October 2018

    Deubiquitination of FANCD2, FANCI, and PCNA by USP1 is essential for DNA repair signalling. Reconstitution of the system reveals that USP1-mediated specificity towards K561 of FANCD2 is directed by a unique sequence at USP1's N-terminus.

  • Atomic force microscopy reveals structural variability amongst nuclear pore complexes
    Open Access
    Atomic force microscopy reveals structural variability amongst nuclear pore complexes

    George J Stanley, Ariberto Fassati, Bart W Hoogenboom

    George J Stanley ... Bart W Hoogenboom

    Published 20 August 2018

    Structural heterogeneity is resolved in isolated nuclear envelopes, revealing the lamina network and nuclear pore complexes of different sizes, as well as different morphologies in their transport barrier and different binding of nuclear transport receptors in the barrier.

  • Beetle luciferases with naturally red- and blue-shifted emission
    Open Access
    Beetle luciferases with naturally red- and blue-shifted emission

    César Carrasco-López, Juliana C Ferreira, Nathan M Lui, Stefan Schramm, Romain Berraud-Pache, Isabelle Navizet, Santosh Panjikar, Panče Naumov, Wael M Rabeh

    César Carrasco-López ... Wael M Rabeh

    Published 16 August 2018

    New crystal structures of red- and green blue–shifted beetle luciferases reveal that the color emission mechanism is dependent on the active site microenvironment affected by the conformation of loop regions.

  • Ribosome recycling is coordinated by processive events in two asymmetric ATP sites of ABCE1
    Open Access
    Ribosome recycling is coordinated by processive events in two asymmetric ATP sites of ABCE1

    Elina Nürenberg-Goloub, Holger Heinemann, Milan Gerovac, Robert Tampé

    Elina Nürenberg-Goloub ... Robert Tampé

    Published 14 June 2018

    The stepwise ribosome disassembly in the translation cycle of eukaryotes and archaea is scheduled by discrete molecular events within the asymmetric ribosome recycling factor ABCE1.

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