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Structural Biology

  • Molecular insights into RNA recognition and gene regulation by the TRIM-NHL protein Mei-P26
    Open Access
    Molecular insights into RNA recognition and gene regulation by the TRIM-NHL protein Mei-P26

    Anna Salerno-Kochan, Andreas Horn, Pritha Ghosh, Chandran Nithin, Anna Kościelniak, Andreas Meindl, Daniela Strauss, Rościsław Krutyhołowa, Oliver Rossbach, Janusz M Bujnicki, Monika Gaik, Jan Medenbach, Sebastian Glatt

    Anna Salerno-Kochan ... Sebastian Glatt

    Published 5 May 2022

    This study provides molecular insights into RNA target recognition by the TRIM-NHL protein Mei-P26 that functions in Drosophila ovarian germline stem cell maintenance, oogenesis, and spermatogenesis.

  • Molecular analysis and essentiality of Aro1 shikimate biosynthesis multi-enzyme in <em>Candida albicans</em>
    Open Access
    Molecular analysis and essentiality of Aro1 shikimate biosynthesis multi-enzyme in Candida albicans

    Peter J Stogios, Sean D Liston, Cameron Semper, Bradley Quade, Karolina Michalska, Elena Evdokimova, Shane Ram, Zbyszek Otwinowski, Dominika Borek, Leah E Cowen, Alexei Savchenko

    Peter J Stogios ... Alexei Savchenko

    Published 5 May 2022

    Structural characterization of shikimate pathway multi-enzyme Aro1 from opportunistic fungal pathogen Candida albicans provides the first molecular image of all five domains. Only four of these domains are active and individually essential for C. albicans viability.

  • Structure and conformational dynamics of <em>Clostridioides difficile</em> toxin A
    Open Access
    Structure and conformational dynamics of Clostridioides difficile toxin A

    Baohua Chen, Sujit Basak, Peng Chen, Changcheng Zhang, Kay Perry, Songhai Tian, Clinton Yu, Min Dong, Lan Huang, Mark E Bowen, Rongsheng Jin

    Baohua Chen ... Rongsheng Jin

    Published 15 March 2022

    This study presents a complete structural model of TcdA holotoxin and sheds new lights into the conformational dynamics of TcdA and its roles in TcdA intoxication.

  • Structural basis of Nrd1–Nab3 heterodimerization
    Open Access
    Structural basis of Nrd1–Nab3 heterodimerization

    Belén Chaves-Arquero, Santiago Martínez-Lumbreras, Sergio Camero, Clara M Santiveri, Yasmina Mirassou, Ramón Campos-Olivas, Maria Ángeles Jiménez, Olga Calvo, José Manuel Pérez-Cañadillas

    Belén Chaves-Arquero ... José Manuel Pérez-Cañadillas

    Published 12 January 2022

    The NMR structure of an Nrd1–Nab3 chimera describes the structural bases of Nrd1/Nab3 heterodimerization. Nrd1 embraces a bundle of helices in Nab3, building a large interface. Key mutations at that interface compromise cell fitness.

  • Structural basis of membrane recognition of <em>Toxoplasma gondii</em> vacuole by Irgb6
    Open Access
    Structural basis of membrane recognition of Toxoplasma gondii vacuole by Irgb6

    Yumiko Saijo-Hamano, Aalaa Alrahman Sherif, Ariel Pradipta, Miwa Sasai, Naoki Sakai, Yoshiaki Sakihama, Masahiro Yamamoto, Daron M Standley, Ryo Nitta

    Yumiko Saijo-Hamano ... Ryo Nitta

    Published 9 November 2021

    Upon Toxoplasma gondii infection, Irgb6 is recruited to the parasitophorous vacuole membrane (PVM) where Irgb6 disrupts it. We solved the atomic structures of Irgb6 in two distinct nucleotide states, revealing a unique PVM-binding interface sensitive to GTPase cycling.

  • The structure and flexibility analysis of the <em>Arabidopsis</em> synaptotagmin 1 reveal the basis of its regulation at membrane contact sites
    Open Access
    The structure and flexibility analysis of the Arabidopsis synaptotagmin 1 reveal the basis of its regulation at membrane contact sites

    Juan L Benavente, Dritan Siliqi, Lourdes Infantes, Laura Lagartera, Alberto Mills, Federico Gago, Noemí Ruiz-López, Miguel A Botella, María J Sánchez-Barrena, Armando Albert

    Juan L Benavente ... Armando Albert

    Published 18 August 2021

    Plant SYT1 transports lipids between endoplasmic reticulum and plasma membrane in response to stress. The protein flexibility and lipid-binding specificity determine SYT1 function at molecular level.

  • Dynamic changes in RNA–protein interactions and RNA secondary structure in mammalian erythropoiesis
    Open Access
    Dynamic changes in RNA–protein interactions and RNA secondary structure in mammalian erythropoiesis

    Mengge Shan, Xinjun Ji, Kevin Janssen, Ian M Silverman, Jesse Humenik, Ben A Garcia, Stephen A Liebhaber, Brian D Gregory

    Mengge Shan ... Brian D Gregory

    Published 27 July 2021

    Analysis of PIP-seq data from a model of erythropoiesis reveals dynamics of RBP–RNA interaction and changes in RNA secondary structure throughout red blood cell development.

  • Dynamic closed states of a ligand-gated ion channel captured by cryo-EM and simulations
    Open Access
    Dynamic closed states of a ligand-gated ion channel captured by cryo-EM and simulations

    Urška Rovšnik, Yuxuan Zhuang, Björn O Forsberg, Marta Carroni, Linnea Yvonnesdotter, Rebecca J Howard, Erik Lindahl

    Urška Rovšnik ... Erik Lindahl

    Published 1 July 2021

    Cryo-EM structures and molecular simulations of a pentameric ligand-gated ion channel, GLIC, in resting and activating conditions implicate protonation sites and altered dynamics in sequential gating.

  • Crystal structure of inhibitor-bound human MSPL that can activate high pathogenic avian influenza
    Open Access
    Crystal structure of inhibitor-bound human MSPL that can activate high pathogenic avian influenza

    Ayako Ohno, Nobuo Maita, Takanori Tabata, Hikaru Nagano, Kyohei Arita, Mariko Ariyoshi, Takayuki Uchida, Reiko Nakao, Anayt Ulla, Kosuke Sugiura, Koji Kishimoto, Shigetada Teshima-Kondo, Yuushi Okumura, Takeshi Nikawa

    Ayako Ohno ... Takeshi Nikawa

    Published 5 April 2021

    The structure of extracellular domain of MSPL and inhibitor complex helps to understand the TTSP functions, including TMPRSS2, and provides the insights of the infection of influenza and SARS-CoV.

  • Structural comparison of GLUT1 to GLUT3 reveal transport regulation mechanism in sugar porter family
    Open Access
    Structural comparison of GLUT1 to GLUT3 reveal transport regulation mechanism in sugar porter family

    Tânia Filipa Custódio, Peter Aasted Paulsen, Kelly May Frain, Bjørn Panyella Pedersen

    Tânia Filipa Custódio ... Bjørn Panyella Pedersen

    Published 3 February 2021

    A new structure of GLUT1, compared with GLUT3, can explain substrate affinity differences, and provide a functional rationale for key structural motifs that define the universal Sugar Porter family.

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