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Stem Cells

  • ROS amplification drives mouse spermatogonial stem cell self-renewal
    Open Access
    ROS amplification drives mouse spermatogonial stem cell self-renewal

    Hiroko Morimoto, Mito Kanastu-Shinohara, Narumi Ogonuki, Satoshi Kamimura, Atsuo Ogura, Chihiro Yabe-Nishimura, Yoshifumi Mori, Takeshi Morimoto, Satoshi Watanabe, Kinya Otsu, Takuya Yamamoto, Takashi Shinohara

    Hiroko Morimoto ... Takashi Shinohara

    Published 2 April 2019

    Although reactive oxygen species (ROS) are required for spermatogonial stem cell (SSC) self-renewal, the mechanism has remained unknown. We show that SSC self-renewal signals activate MAPK14/MAPK7 pathway to induce nuclear translocation of BCL6B and activation of NOX1.

  • Location-dependent maintenance of intrinsic susceptibility to mTORC1-driven tumorigenesis
    Open Access
    Location-dependent maintenance of intrinsic susceptibility to mTORC1-driven tumorigenesis

    Gabrielle V Rushing, Asa A Brockman, Madelyn K Bollig, Nalin Leelatian, Bret C Mobley, Jonathan M Irish, Kevin C Ess, Cary Fu, Rebecca A Ihrie

    Gabrielle V Rushing ... Rebecca A Ihrie

    Published 25 March 2019

    Per-cell quantification of mTORC1 signaling activity in neural stem/progenitor cells reveals differential signaling, proliferative, and tumor-forming capability between dorsal and ventral cells within a single niche.

  • Assessment and site-specific manipulation of DNA (hydroxy-)methylation during mouse corticogenesis
    Open Access
    Assessment and site-specific manipulation of DNA (hydroxy-)methylation during mouse corticogenesis

    Florian Noack, Abhijeet Pataskar, Martin Schneider, Frank Buchholz, Vijay K Tiwari, Federico Calegari

    Florian Noack ... Federico Calegari

    Published 27 February 2019

    This work describes the dynamics of DNA modifications in specific cell types of the developing mammalian cortex. By providing a new method to manipulate this process in vivo, it is shown how this process can influence brain formation.

  • Polycomb and Notch signaling regulate cell proliferation potential during <em>Caenorhabditis elegans</em> life cycle
    Open Access
    Polycomb and Notch signaling regulate cell proliferation potential during Caenorhabditis elegans life cycle

    Francesca Coraggio, Ringo Püschel, Alisha Marti, Peter Meister

    Francesca Coraggio ... Peter Meister

    Published 26 December 2018

    Caenorhabditis elegans lineage is invariant between animals. By challenging cell fate in differentiated worms, an unexpected role of Polycomb and Notch signaling in the control of cell proliferation was uncovered, suggesting that the lineage is more flexible than believed.

  • A C/EBPα–Wnt connection in gut homeostasis and carcinogenesis
    Open Access
    A C/EBPα–Wnt connection in gut homeostasis and carcinogenesis

    Julian Heuberger, Undine Hill, Susann Förster, Karin Zimmermann, Victoria Malchin, Anja A Kühl, Ulrike Stein, Michael Vieth, Walter Birchmeier, Achim Leutz

    Julian Heuberger ... Achim Leutz

    Published 26 December 2018

    This research reveals an antagonism between C/EBPα expression and activated Wnt signaling in the human and mouse gut and suggests a tumor suppressor function of C/EBPα in human and murine intestinal cancer.

  • Variants of <em>DNMT3A</em> cause transcript-specific DNA methylation patterns and affect hematopoiesis
    Open Access
    Variants of DNMT3A cause transcript-specific DNA methylation patterns and affect hematopoiesis

    Tanja Božić, Joana Frobel, Annamarija Raic, Fabio Ticconi, Chao-Chung Kuo, Stefanie Heilmann-Heimbach, Tamme W Goecke, Martin Zenke, Edgar Jost, Ivan G Costa, Wolfgang Wagner

    Tanja Božić ... Wolfgang Wagner

    Published 13 December 2018

    Modulation of DNMT3A splice variants causes transcript-specific DNA methylation and gene expression changes and affects differentiation. Particularly, transcript 2 is relevant in acute myeloid leukemia.

  • Chromatin-mediated translational control is essential for neural cell fate specification
    Open Access
    Chromatin-mediated translational control is essential for neural cell fate specification

    Dong-Woo Hwang, Anbalagan Jaganathan, Padmina Shrestha, Ying Jin, Nour El-Amine, Sidney H Wang, Molly Hammell, Alea A Mills

    Dong-Woo Hwang ... Alea A Mills

    Published 23 August 2018

    Chd5 loss links the up-regulation of ribosomal genes to enhanced translation, causing the untimely production of a master transcription factor that unleashes stem cells and alters cell fate.

  • Pericytes promote skin regeneration by inducing epidermal cell polarity and planar cell divisions
    Open Access
    Pericytes promote skin regeneration by inducing epidermal cell polarity and planar cell divisions

    Lizhe Zhuang, Kynan T Lawlor, Holger Schlueter, Zalitha Pieterse, Yu Yu, Pritinder Kaur

    Lizhe Zhuang ... Pritinder Kaur

    Published 24 July 2018

    This study reveals that mesenchymal stem cell–like dermal pericytes increase the number of epidermal stem and progenitor cells in human skin by promoting planar cell divisions within the proliferative compartment, without compromising skin differentiation—most likely via paracrine BMP-2 secretion.

  • JIP2 haploinsufficiency contributes to neurodevelopmental abnormalities in human pluripotent stem cell–derived neural progenitors and cortical neurons
    Open Access
    JIP2 haploinsufficiency contributes to neurodevelopmental abnormalities in human pluripotent stem cell–derived neural progenitors and cortical neurons

    Reinhard Roessler, Johanna Goldmann, Chikdu Shivalila, Rudolf Jaenisch

    Reinhard Roessler ... Rudolf Jaenisch

    Published 25 June 2018

    Molecular and cellular profiling of patient-specific neural cell types provides suggestions for the involvement of JIP2 in the neurodevelopmental disorder Phelan–McDermid syndrome.

  • Transcriptional repression by FACT is linked to regulation of chromatin accessibility at the promoter of ES cells
    Open Access
    Transcriptional repression by FACT is linked to regulation of chromatin accessibility at the promoter of ES cells

    Constantine Mylonas, Peter Tessarz

    Constantine Mylonas ... Peter Tessarz

    Published 13 June 2018

    Depletion of FACT in murine embryonic stem cells show mild changes on the nucleosomal landscape but widespread changes in the transcriptome, faster proliferation, and neuronal differentiation rates.

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