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Stem Cells

  • Robust production of uniform human cerebral organoids from pluripotent stem cells
    Open Access
    Robust production of uniform human cerebral organoids from pluripotent stem cells

    Adam A Sivitilli, Jessica T Gosio, Bibaswan Ghoshal, Alesya Evstratova, Daniel Trcka, Parisa Ghiasi, J Javier Hernandez, Jean Martin Beaulieu, Jeffrey L Wrana, Liliana Attisano

    Adam A Sivitilli ... Liliana Attisano

    Published 17 April 2020

    By leveraging advances in 3D stem cell culture techniques, the authors describe, characterize and validate a novel platform to efficiently generate morphologically consistent human forebrain cerebral organoids.

  • The molecular clock protein Bmal1 regulates cell differentiation in mouse embryonic stem cells
    Open Access
    The molecular clock protein Bmal1 regulates cell differentiation in mouse embryonic stem cells

    Amador Gallardo, Aldara Molina, Helena G Asenjo, Jordi Martorell-Marugán, Rosa Montes, Verónica Ramos-Mejia, Antonio Sanchez-Pozo, Pedro Carmona-Sáez, Lourdes Lopez-Onieva, David Landeira

    Amador Gallardo ... David Landeira

    Published 13 April 2020

    Analysis of the role of the molecular clock protein Bmal1 in pluripotent embryonic stem cells reveals a novel function of circadian proteins in cell differentiation and early embryo development.

  • BMAL1 coordinates energy metabolism and differentiation of pluripotent stem cells
    Open Access
    BMAL1 coordinates energy metabolism and differentiation of pluripotent stem cells

    Cristina Ameneiro, Tiago Moreira, Alejandro Fuentes-Iglesias, Alba Coego, Vera Garcia-Outeiral, Adriana Escudero, Daniel Torrecilla, Sonia Mulero-Navarro, Jose Maria Carvajal-Gonzalez, Diana Guallar, Miguel Fidalgo

    Cristina Ameneiro ... Miguel Fidalgo

    Published 13 April 2020

    Although pluripotent cells lack circadian oscillations, this study reveals a novel function of the master circadian regulator BMAL1 in metabolism and early differentiation of embryonic stem cells.

  • The stress polarity signaling (SPS) pathway serves as a marker and a target in the leaky gut barrier: implications in aging and cancer
    Open Access
    The stress polarity signaling (SPS) pathway serves as a marker and a target in the leaky gut barrier: implications in aging and cancer

    Pradipta Ghosh, Lee Swanson, Ibrahim M Sayed, Yash Mittal, Blaze B Lim, Stella-Rita Ibeawuchi, Marc Foretz, Benoit Viollet, Debashis Sahoo, Soumita Das

    Pradipta Ghosh ... Soumita Das

    Published 10 February 2020

    Using patient-derived organoids the authors show how a specialized polarity pathway protects our gut barrier from stress-induced collapse. Findings highlight both diagnostic and therapeutic potential of the pathway for treating gut barrier dysfunction in aging, cancer, and dysbiosis.

  • Metabolic reprogramming of fibro/adipogenic progenitors facilitates muscle regeneration
    Open Access
    Metabolic reprogramming of fibro/adipogenic progenitors facilitates muscle regeneration

    Alessio Reggio, Marco Rosina, Natalie Krahmer, Alessandro Palma, Lucia Lisa Petrilli, Giuliano Maiolatesi, Giorgia Massacci, Illari Salvatori, Cristiana Valle, Stefano Testa, Cesare Gargioli, Claudia Fuoco, Luisa Castagnoli, Gianni Cesareni, Francesca Sacco

    Alessio Reggio ... Francesca Sacco

    Published 4 February 2020

    High-fat diet ameliorates muscle dystrophic phenotype by promoting the FAP-dependent myogenesis of satellite cells.

  • Refining the adipose progenitor cell landscape in healthy and obese visceral adipose tissue using single-cell gene expression profiling
    Open Access
    Refining the adipose progenitor cell landscape in healthy and obese visceral adipose tissue using single-cell gene expression profiling

    Dong Seong Cho, Bolim Lee, Jason D Doles

    Dong Seong Cho ... Jason D Doles

    Published 25 November 2019

    This work dissects adipose progenitor cell (APC) heterogeneity in normal and obese adipose tissue using single-cell expression profiling. Novel APC subpopulations are identified and characterized.

  • Defining the expression of piRNA and transposable elements in <em>Drosophila</em> ovarian germline stem cells and somatic support cells
    Open Access
    Defining the expression of piRNA and transposable elements in Drosophila ovarian germline stem cells and somatic support cells

    Benjamin Story, Xing Ma, Kazue Ishihara, Hua Li, Kathryn Hall, Allison Peak, Perera Anoja, Jungeun Park, Jeff Haug, Marco Blanchette, Ting Xie

    Benjamin Story ... Ting Xie

    Published 16 October 2019

    Comprehensive transcriptional characterization of mRNA and small RNA in early Drosophila germline stem cells reveals novel piRNA clusters, transposon dynamics, and alternative splicing events.

  • Endogenous epitope-tagging of <em>Tet1</em>, <em>Tet2</em> and <em>Tet3</em> identifies TET2 as a naïve pluripotency marker
    Open Access
    Endogenous epitope-tagging of Tet1, Tet2 and Tet3 identifies TET2 as a naïve pluripotency marker

    Raphaël Pantier, Tülin Tatar, Douglas Colby, Ian Chambers

    Raphaël Pantier ... Ian Chambers

    Published 3 October 2019

    Expression of TET proteins in pluripotent cell types is visualised by epitope tagging of endogenous alleles.

  • Glycine cleavage system determines the fate of pluripotent stem cells via the regulation of senescence and epigenetic modifications
    Open Access
    Glycine cleavage system determines the fate of pluripotent stem cells via the regulation of senescence and epigenetic modifications

    Shengya Tian, Junru Feng, Yang Cao, Shengqi Shen, Yongping Cai, Dongdong Yang, Ronghui Yan, Lihua Wang, Huafeng Zhang, Xiuying Zhong, Ping Gao

    Shengya Tian ... Ping Gao

    Published 27 September 2019

    The glycine cleavage system (GCS) is highly activated to promote stem cell pluripotency. The GCS catabolizes glycine to prevent methylglyoxal accumulation and to fuel H3K4me3 modification, promoting the expression of pluripotency genes.

  • Constitutive STAT5 activation regulates Paneth and Paneth-like cells to control <em>Clostridium difficile</em> colitis
    Open Access
    Constitutive STAT5 activation regulates Paneth and Paneth-like cells to control Clostridium difficile colitis

    Ruixue Liu, Richard Moriggl, Dongsheng Zhang, Haifeng Li, Rebekah Karns, Hai-Bin Ruan, Haitao Niu, Christopher Mayhew, Carey Watson, Hansraj Bangar, Sang-wook Cha, David Haslam, Tongli Zhang, Shila Gilbert, Na Li, Michael Helmrath, James Wells, Lee Denson, Xiaonan Han

    Ruixue Liu ... Xiaonan Han

    Published 4 April 2019

    STAT5 controls the intestinal epithelial stem cell niche by regulating Wnt/β-catenin signaling, and lack of active pYSTAT5 induces Clostridium difficile infection. STAT5 may be a transcription factor that restricts niche cell differentiation.

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