Stem Cells
Variants of DNMT3A cause transcript-specific DNA methylation patterns and affect hematopoiesisModulation of DNMT3A splice variants causes transcript-specific DNA methylation and gene expression changes and affects differentiation. Particularly, transcript 2 is relevant in acute myeloid leukemia.
Chromatin-mediated translational control is essential for neural cell fate specificationChd5 loss links the up-regulation of ribosomal genes to enhanced translation, causing the untimely production of a master transcription factor that unleashes stem cells and alters cell fate.
Pericytes promote skin regeneration by inducing epidermal cell polarity and planar cell divisionsThis study reveals that mesenchymal stem cell–like dermal pericytes increase the number of epidermal stem and progenitor cells in human skin by promoting planar cell divisions within the proliferative compartment, without compromising skin differentiation—most likely via paracrine BMP-2 secretion.
JIP2 haploinsufficiency contributes to neurodevelopmental abnormalities in human pluripotent stem cell–derived neural progenitors and cortical neuronsMolecular and cellular profiling of patient-specific neural cell types provides suggestions for the involvement of JIP2 in the neurodevelopmental disorder Phelan–McDermid syndrome.
Transcriptional repression by FACT is linked to regulation of chromatin accessibility at the promoter of ES cellsDepletion of FACT in murine embryonic stem cells show mild changes on the nucleosomal landscape but widespread changes in the transcriptome, faster proliferation, and neuronal differentiation rates.