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Stem Cells

  • Refining the adipose progenitor cell landscape in healthy and obese visceral adipose tissue using single-cell gene expression profiling
    Open Access
    Refining the adipose progenitor cell landscape in healthy and obese visceral adipose tissue using single-cell gene expression profiling

    Dong Seong Cho, Bolim Lee, Jason D Doles

    Dong Seong Cho ... Jason D Doles

    Published 25 November 2019

    This work dissects adipose progenitor cell (APC) heterogeneity in normal and obese adipose tissue using single-cell expression profiling. Novel APC subpopulations are identified and characterized.

  • Defining the expression of piRNA and transposable elements in <em>Drosophila</em> ovarian germline stem cells and somatic support cells
    Open Access
    Defining the expression of piRNA and transposable elements in Drosophila ovarian germline stem cells and somatic support cells

    Benjamin Story, Xing Ma, Kazue Ishihara, Hua Li, Kathryn Hall, Allison Peak, Perera Anoja, Jungeun Park, Jeff Haug, Marco Blanchette, Ting Xie

    Benjamin Story ... Ting Xie

    Published 16 October 2019

    Comprehensive transcriptional characterization of mRNA and small RNA in early Drosophila germline stem cells reveals novel piRNA clusters, transposon dynamics, and alternative splicing events.

  • Endogenous epitope-tagging of <em>Tet1</em>, <em>Tet2</em> and <em>Tet3</em> identifies TET2 as a naïve pluripotency marker
    Open Access
    Endogenous epitope-tagging of Tet1, Tet2 and Tet3 identifies TET2 as a naïve pluripotency marker

    Raphaël Pantier, Tülin Tatar, Douglas Colby, Ian Chambers

    Raphaël Pantier ... Ian Chambers

    Published 3 October 2019

    Expression of TET proteins in pluripotent cell types is visualised by epitope tagging of endogenous alleles.

  • Glycine cleavage system determines the fate of pluripotent stem cells via the regulation of senescence and epigenetic modifications
    Open Access
    Glycine cleavage system determines the fate of pluripotent stem cells via the regulation of senescence and epigenetic modifications

    Shengya Tian, Junru Feng, Yang Cao, Shengqi Shen, Yongping Cai, Dongdong Yang, Ronghui Yan, Lihua Wang, Huafeng Zhang, Xiuying Zhong, Ping Gao

    Shengya Tian ... Ping Gao

    Published 27 September 2019

    The glycine cleavage system (GCS) is highly activated to promote stem cell pluripotency. The GCS catabolizes glycine to prevent methylglyoxal accumulation and to fuel H3K4me3 modification, promoting the expression of pluripotency genes.

  • Constitutive STAT5 activation regulates Paneth and Paneth-like cells to control <em>Clostridium difficile</em> colitis
    Open Access
    Constitutive STAT5 activation regulates Paneth and Paneth-like cells to control Clostridium difficile colitis

    Ruixue Liu, Richard Moriggl, Dongsheng Zhang, Haifeng Li, Rebekah Karns, Hai-Bin Ruan, Haitao Niu, Christopher Mayhew, Carey Watson, Hansraj Bangar, Sang-wook Cha, David Haslam, Tongli Zhang, Shila Gilbert, Na Li, Michael Helmrath, James Wells, Lee Denson, Xiaonan Han

    Ruixue Liu ... Xiaonan Han

    Published 4 April 2019

    STAT5 controls the intestinal epithelial stem cell niche by regulating Wnt/β-catenin signaling, and lack of active pYSTAT5 induces Clostridium difficile infection. STAT5 may be a transcription factor that restricts niche cell differentiation.

  • ROS amplification drives mouse spermatogonial stem cell self-renewal
    Open Access
    ROS amplification drives mouse spermatogonial stem cell self-renewal

    Hiroko Morimoto, Mito Kanastu-Shinohara, Narumi Ogonuki, Satoshi Kamimura, Atsuo Ogura, Chihiro Yabe-Nishimura, Yoshifumi Mori, Takeshi Morimoto, Satoshi Watanabe, Kinya Otsu, Takuya Yamamoto, Takashi Shinohara

    Hiroko Morimoto ... Takashi Shinohara

    Published 2 April 2019

    Although reactive oxygen species (ROS) are required for spermatogonial stem cell (SSC) self-renewal, the mechanism has remained unknown. We show that SSC self-renewal signals activate MAPK14/MAPK7 pathway to induce nuclear translocation of BCL6B and activation of NOX1.

  • Location-dependent maintenance of intrinsic susceptibility to mTORC1-driven tumorigenesis
    Open Access
    Location-dependent maintenance of intrinsic susceptibility to mTORC1-driven tumorigenesis

    Gabrielle V Rushing, Asa A Brockman, Madelyn K Bollig, Nalin Leelatian, Bret C Mobley, Jonathan M Irish, Kevin C Ess, Cary Fu, Rebecca A Ihrie

    Gabrielle V Rushing ... Rebecca A Ihrie

    Published 25 March 2019

    Per-cell quantification of mTORC1 signaling activity in neural stem/progenitor cells reveals differential signaling, proliferative, and tumor-forming capability between dorsal and ventral cells within a single niche.

  • Assessment and site-specific manipulation of DNA (hydroxy-)methylation during mouse corticogenesis
    Open Access
    Assessment and site-specific manipulation of DNA (hydroxy-)methylation during mouse corticogenesis

    Florian Noack, Abhijeet Pataskar, Martin Schneider, Frank Buchholz, Vijay K Tiwari, Federico Calegari

    Florian Noack ... Federico Calegari

    Published 27 February 2019

    This work describes the dynamics of DNA modifications in specific cell types of the developing mammalian cortex. By providing a new method to manipulate this process in vivo, it is shown how this process can influence brain formation.

  • Polycomb and Notch signaling regulate cell proliferation potential during <em>Caenorhabditis elegans</em> life cycle
    Open Access
    Polycomb and Notch signaling regulate cell proliferation potential during Caenorhabditis elegans life cycle

    Francesca Coraggio, Ringo Püschel, Alisha Marti, Peter Meister

    Francesca Coraggio ... Peter Meister

    Published 26 December 2018

    Caenorhabditis elegans lineage is invariant between animals. By challenging cell fate in differentiated worms, an unexpected role of Polycomb and Notch signaling in the control of cell proliferation was uncovered, suggesting that the lineage is more flexible than believed.

  • A C/EBPα–Wnt connection in gut homeostasis and carcinogenesis
    Open Access
    A C/EBPα–Wnt connection in gut homeostasis and carcinogenesis

    Julian Heuberger, Undine Hill, Susann Förster, Karin Zimmermann, Victoria Malchin, Anja A Kühl, Ulrike Stein, Michael Vieth, Walter Birchmeier, Achim Leutz

    Julian Heuberger ... Achim Leutz

    Published 26 December 2018

    This research reveals an antagonism between C/EBPα expression and activated Wnt signaling in the human and mouse gut and suggests a tumor suppressor function of C/EBPα in human and murine intestinal cancer.

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