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Stem Cells

  • Molecular insights into RNA recognition and gene regulation by the TRIM-NHL protein Mei-P26
    Open Access
    Molecular insights into RNA recognition and gene regulation by the TRIM-NHL protein Mei-P26

    Anna Salerno-Kochan, Andreas Horn, Pritha Ghosh, Chandran Nithin, Anna Kościelniak, Andreas Meindl, Daniela Strauss, Rościsław Krutyhołowa, Oliver Rossbach, Janusz M Bujnicki, Monika Gaik, Jan Medenbach, Sebastian Glatt

    Anna Salerno-Kochan ... Sebastian Glatt

    Published 5 May 2022

    This study provides molecular insights into RNA target recognition by the TRIM-NHL protein Mei-P26 that functions in Drosophila ovarian germline stem cell maintenance, oogenesis, and spermatogenesis.

  • Reduced adhesion of aged intestinal stem cells contributes to an accelerated clonal drift
    Open Access
    Reduced adhesion of aged intestinal stem cells contributes to an accelerated clonal drift

    Ali Hageb, Torsten Thalheim, Kalpana J Nattamai, Bettina Möhrle, Mehmet Saçma, Vadim Sakk, Lars Thielecke, Kerstin Cornils, Carolin Grandy, Fabian Port, Kay-E Gottschalk, Jan-Philipp Mallm, Ingmar Glauche, Jörg Galle, Medhanie A Mulaw, Hartmut Geiger

    Ali Hageb ... Hartmut Geiger

    Published 29 April 2022

    Analysis of clonal dynamics of intestinal stem cells supports an accelerated clonal drift upon aging, likely because of reduced adhesion of aged ISCs because of reduced canonical Wnt signaling.

  • Nutrient sensitive protein <em>O</em>-GlcNAcylation modulates the transcriptome through epigenetic mechanisms during embryonic neurogenesis
    Open Access
    Nutrient sensitive protein O-GlcNAcylation modulates the transcriptome through epigenetic mechanisms during embryonic neurogenesis

    Shama Parween, Thilina T Alawathugoda, Ashok D Prabakaran, S Thameem Dheen, Randall H Morse, Bright Starling Emerald, Suraiya A Ansari

    Shama Parween ... Suraiya A Ansari

    Published 25 April 2022

    Maternal hyperglycemia and elevated O-GlcNAc levels perturb promoter bivalency and lead to transcriptional up-regulation of neurogenic transcription factors during embryonic neurogenesis.

  • Single-cell RNA-seq reveals heterogeneity in hiPSC-derived muscle progenitors and E2F family as a key regulator of proliferation
    Open Access
    Single-cell RNA-seq reveals heterogeneity in hiPSC-derived muscle progenitors and E2F family as a key regulator of proliferation

    Minas Nalbandian, Mingming Zhao, Hiroki Kato, Tatsuya Jonouchi, May Nakajima-Koyama, Takuya Yamamoto, Hidetoshi Sakurai

    Minas Nalbandian ... Hidetoshi Sakurai

    Published 22 April 2022

    This study identified and characterized four different populations of muscle progenitor cells derived from human induced pluripotent stem cells.

  • AGO1 regulates pericentromeric regions in mouse embryonic stem cells
    Open Access
    AGO1 regulates pericentromeric regions in mouse embryonic stem cells

    Madlen Müller, Tara Fäh, Moritz Schaefer, Victoria Hermes, Janina Luitz, Patrick Stalder, Rajika Arora, Richard Patryk Ngondo, Constance Ciaudo

    Madlen Müller ... Constance Ciaudo

    Published 2 March 2022

    Depletion of AGO1 in mESCs leads to a redistribution of H3K9me3 and HP1α away from pericentromeric regions and is accompanied by an up-regulation of major satellites transcripts.

  • Muscle stem cell polarity requires QKI-mediated alternative splicing of Integrin Alpha-7 (Itga7)
    Open Access
    Muscle stem cell polarity requires QKI-mediated alternative splicing of Integrin Alpha-7 (Itga7)

    Claudia Dominici, Stéphane Richard

    Claudia Dominici ... Stéphane Richard

    Published 14 February 2022

    The RNA-binding protein Quaking (QKI) is a post-transcriptional regulator of genes encoding polarity proteins in muscle stem cells. Loss of QKI in MuSCs results in reduced myogenic progenitors and a striking muscle regeneration defect.

  • HERVH-derived lncRNAs negatively regulate chromatin targeting and remodeling mediated by CHD7
    Open Access
    HERVH-derived lncRNAs negatively regulate chromatin targeting and remodeling mediated by CHD7

    Fu-Kai Hsieh, Fei Ji, Manashree Damle, Ruslan I Sadreyev, Robert E Kingston

    Fu-Kai Hsieh ... Robert E Kingston

    Published 18 October 2021

    Mutations in CHD7 are diagnostic for human CHARGE syndrome. RNAs expressed from the HERVH repeats modulate CHD7 function providing one mechanism for regulation of differentiation of pluripotent cells.

  • Differential impact of a dyskeratosis congenita mutation in TPP1 on mouse hematopoiesis and germline
    Open Access
    Differential impact of a dyskeratosis congenita mutation in TPP1 on mouse hematopoiesis and germline

    Jacqueline V Graniel, Kamlesh Bisht, Ann Friedman, James White, Eric Perkey, Ashley Vanderbeck, Alina Moroz, Léolène J Carrington, Joshua D Brandstadter, Frederick Allen, Adrienne Niederriter Shami, Peedikayil Thomas, Aniela Crayton, Mariel Manzor, Anna Mychalowych, Jennifer Chase, Saher S Hammoud, Catherine E Keegan, Ivan Maillard, Jayakrishnan Nandakumar

    Jacqueline V Graniel ... Jayakrishnan Nandakumar

    Published 13 October 2021

    A TPP1 mutation known to cause telomere shortening and bone marrow failure in humans recapitulates telomere loss but results in severe germline defects in mice without impacting murine hematopoiesis.

  • Kinomics platform using GBM tissue identifies BTK as being associated with higher patient survival
    Open Access
    Kinomics platform using GBM tissue identifies BTK as being associated with higher patient survival

    Sofian Al Shboul, Olimpia E Curran, Javier A Alfaro, Fiona Lickiss, Erisa Nita, Jacek Kowalski, Faris Naji, Rudolf Nenutil, Kathryn L Ball, Radovan Krejcir, Borivoj Vojtesek, Ted R Hupp, Paul M Brennan

    Sofian Al Shboul ... Paul M Brennan

    Published 13 October 2021

    BTK is a dominant bioactive kinase expressed within both cancer and immune cells of GBM tissue. Complex cell co-cultures might better model the impact of kinase inhibitors as therapeutics in GBM.

  • Loss of <em>Resf1</em> reduces the efficiency of embryonic stem cell self-renewal and germline entry
    Open Access
    Loss of Resf1 reduces the efficiency of embryonic stem cell self-renewal and germline entry

    Matúš Vojtek, Ian Chambers

    Matúš Vojtek ... Ian Chambers

    Published 4 October 2021

    RESF1 supports ESC self-renewal by raising expression of transmembrane LIF receptor and key pluripotency transcription factors and increases in vitro primordial germ cell differentiation efficiency.

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