Stem Cells
Canonical and non-canonical PRC1 differentially contribute to regulation of neural stem cell fateEpigenetic regulation affects the capacity of stem cells to proliferate and differentiate, with canonical PRC1 being particularly important for neural stem cell fate.
Transcription factor EB (TFEB) activity increases resistance of TNBC stem cells to metabolic stressTFEB promotes TNBC self-renewal and protects TNBC stem cells against metabolic stress via unfolded protein response and autophagy, revealing vulnerabilities that could be therapeutically exploited.
PTPN1/2 inhibition promotes muscle stem cell differentiation in Duchenne muscular dystrophyOur study identifies PTPN1/2 as potential therapeutic targets for Duchenne muscular dystrophy and suggests the use of PTPN1/2 inhibitors to enhance the myogenic function of DMD muscle stem cells.
Cellular stress and epigenetic regulation in adult stem cellsStem cells’ response to various stresses and the epigenetic scarring that remains after the stress has been mitigated is highly relevant to stem cell function.
Differential modulation of polycomb-associated histone marks by cBAF, pBAF, and gBAF complexesThis study shows that the canonical BAF (cBAF) complex uniquely opposes polycomb-associated repressive marks at the Nkx2-9 gene in mouse embryonic stem cells, leading to transcriptional activation, a function not shared by gBAF or pBAF complexes.
Helicobacter pylori induces the expression of Lgr5 and stem cell properties in gastric target cellsHelicobacter pylori infection induces Lgr5 expression and stem cell properties in its target cells in a type IV secretion system/NF-kB-dependent manner. This effect on stemness is exacerbated by constitutive Wnt pathway activation and persists after antibiotic eradication.
ER procollagen storage defect without coupled unfolded protein response drives precocious arthritisThe molecular basis of a collagenopathy is evaluated in an expandable human cartilage model of disease. The pathologic Gly1170Ser substitution causes an ER storage phenotype without inducing the unfolded protein response. This cartilage model could accelerate screening for potential therapies.
STAT3 inhibition recovers regeneration of aged muscles by restoring autophagy in muscle stem cellsThis study shows that STAT3 regulates MuSC function by both transcription-dependent and transcription-independent control of autophagy. STAT3 inhibition reverses age-dependent impairment of muscle regeneration, by restoring autophagy in aged MuSCs.
GDF15 controls primary cilia morphology and function thereby affecting progenitor proliferationGDF15/GFRAL ciliary signalling affects cilia morphology, function and proliferation of progenitors contacting the lateral ventricle from late development onwards.
Lineage-specific changes in mitochondrial properties during neural stem cell differentiationDuring SVZ-derived NSC differentiation, Mfn1/2 levels increase, whereas DRP1 levels significantly decrease. Alterations in mitochondrial morphology and bioenergetics are lineage-specific.