Physiology
Cardiac Plin5 interacts with SERCA2 and promotes calcium handling and cardiomyocyte contractilityWe show that elevated cardiac Plin5 correlates with up-regulation of cardiac contraction–related processes, unraveling a novel Plin5 interaction with SERCA2 associated with improved calcium handling.
S417 in the CC3 region of STIM1 is critical for STIM1-Orai1 binding and CRAC channel activationThis study shows that S417 of STIM1 plays an essential role in STIM1 C-terminus–Orai1 interaction and CRAC channel activation. It also presents new findings about 2-APB’s action on CRAC channel, which provides a tool for better understanding of SOCE activation.
Human adenylyl cyclase 9 is auto-stimulated by its isoform-specific C-terminal domainThe isoform-specific carboxyl-terminal domain stimulates cAMP production by AC9 and also prevents its activation by cell-surface receptors. An interplay between the coiled-coil and the carboxyl-terminal domain of AC9 in regulating cAMP output is also shown.
Integrin ligands block mechanical signal transduction in baroreceptorsThe binding of integrins to specific sequences in extracellular matrix forms the mechanical coupling to transfer stretch applied on the vascular wall to the baroreceptors.
Palmitate impairs circadian transcriptomics in muscle cells through histone modification of enhancersThe disruption of circadian rhythms because of lipid overload may lead to epigenomic changes that influence metabolism. Thus, a dietary or therapeutic modulation of lipid levels, a cornerstone in the treatment of metabolic disorders, may prevent circadian misalignment in peripheral tissues.
Mitochondrial impairment and intracellular reactive oxygen species alter primary cilia morphologyThis work shows how altering energetic status and promoting intracellular/mitochondrial ROS induces cell-dependent ciliary impairments, which is relevant in diseases characterized by these features.
Mitochondrial stress-induced GFRAL signaling controls diurnal food intake and anxiety-like behaviorMuscle mitochondrial stress signals to the brain via hindbrain-specific GFRAL receptor signaling to promote hypothalamic CRH induction, which associates with GFRAL-dependent modulation of systemic energy metabolism, diurnal food intake, and anxiety-like behavior.
Lack of bombesin receptor–activated protein attenuates bleomycin-induced pulmonary fibrosis in miceEnhanced autophagic activity in fibroblasts due to lack of BRAP homologous protein might contribute to the resistance to pulmonary fibrosis in mice.
TMBIM5 loss of function alters mitochondrial matrix ion homeostasis and causes a skeletal myopathyTMBIM5 deficiency reduces mitochondrial K+/H+ exchange. Mutation of the channel pore in mice destabilizes the protein and results in increased embryonic lethality and a skeletal myopathy.
Septins tune lipid kinase activity and PI(4,5)P2 turnover during G-protein–coupled PLC signalling in vivoIn Drosophila photoreceptors, PI(4,5)P2 synthesis during PLC signalling is regulated by PIP5K and septins.