Physiology
- Hypoxia controls expression of kidney-pathogenic MUC1 variants
Hypoxia or pharmacological treatment with novel HIF stabilizers promotes the expression of MUC1 genetic variants that predispose to the development of chronic kidney disease in renal tubular cells.
- Yolk-deprived Caenorhabditis elegans secure brood size at the expense of competitive fitness
Many egg-laying species lower fecundity when yolk is in short supply, but not C. elegans. They still produce abundant offspring, yet of decreased quality.
- Local tissue mechanics control cardiac pacemaker cell embryonic patterning
Microenvironmental patterning during sinoatrial node morphogenesis is critical for sustaining cardiac pacemaker cell function.
- Expansion microscopy reveals subdomains in C. elegans germ granules
Visualising C. elegans germ granules using the super resolution technique expansion microscopy against the backdrop of proteome staining reveals granule ultrastructure.
- The ADAM17 sheddase complex regulator iTAP/Frmd8 modulates inflammation and tumor growth
The FERM domain protein iTAP/Frmd8, which binds to and stabilizes the ADAM17/iRhom sheddase complex at the cell surface, is a regulator of inflammation, epithelial homeostasis, and tumor growth in vivo.
- Cardiac Plin5 interacts with SERCA2 and promotes calcium handling and cardiomyocyte contractility
We show that elevated cardiac Plin5 correlates with up-regulation of cardiac contraction–related processes, unraveling a novel Plin5 interaction with SERCA2 associated with improved calcium handling.
- S417 in the CC3 region of STIM1 is critical for STIM1-Orai1 binding and CRAC channel activation
This study shows that S417 of STIM1 plays an essential role in STIM1 C-terminus–Orai1 interaction and CRAC channel activation. It also presents new findings about 2-APB’s action on CRAC channel, which provides a tool for better understanding of SOCE activation.
- Human adenylyl cyclase 9 is auto-stimulated by its isoform-specific C-terminal domain
The isoform-specific carboxyl-terminal domain stimulates cAMP production by AC9 and also prevents its activation by cell-surface receptors. An interplay between the coiled-coil and the carboxyl-terminal domain of AC9 in regulating cAMP output is also shown.
- Unconventional interactions of the TRPV4 ion channel with beta-adrenergic receptor ligands
The transient receptor potential vanilloid (TRPV4) ion channel is important for respiratory function. Here, it is shown that TRPV4 is inhibited by bronchodilators widely used in diseases such as asthma.
- Integrin ligands block mechanical signal transduction in baroreceptors
The binding of integrins to specific sequences in extracellular matrix forms the mechanical coupling to transfer stretch applied on the vascular wall to the baroreceptors.