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Physiology

  • Multiple membrane extrusion sites drive megakaryocyte migration into bone marrow blood vessels
    Open Access
    Multiple membrane extrusion sites drive megakaryocyte migration into bone marrow blood vessels

    Edward Brown, Leo M Carlin, Claus Nerlov, Cristina Lo Celso, Alastair W Poole

    Edward Brown ... Alastair W Poole

    Published 21 May 2018

    Megakaryocytes enter bone marrow sinusoids to generate platelets by extrusion of internal membrane into the plasma membrane at fusion sites rather than microtubule-driven proplatelet extension.

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