Physiology
Performance and robustness analysis reveals phenotypic trade-offs in yeastThis study combines phenotypic data from yeast cultivations with quantification of robustness over a defined perturbation space, revealing trade-offs between performance and robustness.
Fn14 promotes myoblast fusion during regenerative myogenesisGenetic and molecular approaches demonstrate that Fn14 receptor–mediated signaling improves myoblast fusion during skeletal muscle regeneration in a cell-autonomous manner.
Huntingtin loss in hepatocytes is associated with altered metabolism, adhesion, and liver zonationLifelong huntingtin loss in mouse hepatocytes is associated with altered metabolism, adhesion, and liver zonation which mimics the phenotypes caused by impaired B-catenin function.
Decoding the obesity–cancer connection: lessons from preclinical models of pancreatic adenocarcinomaPreclinical models demonstrate that obesity reprograms the pretumor or tumor cell and its micro- and macro-environments to drive cancer development via altered cellular metabolism, hormone dysregulation, inflammation, and microbial dysbiosis.
ERK1/2-SOX9/FOXL2 axis regulates ovarian steroidogenesis and favors the follicular–luteal transitionERK1/2 negatively regulates estradiol synthesis while positively regulating progesterone production in ovarian granulosa cells via the ERK1/2-SOX9/FOXL2 axis.
Hypoxia controls expression of kidney-pathogenic MUC1 variantsHypoxia or pharmacological treatment with novel HIF stabilizers promotes the expression of MUC1 genetic variants that predispose to the development of chronic kidney disease in renal tubular cells.
Yolk-deprived Caenorhabditis elegans secure brood size at the expense of competitive fitnessMany egg-laying species lower fecundity when yolk is in short supply, but not C. elegans. They still produce abundant offspring, yet of decreased quality.
Local tissue mechanics control cardiac pacemaker cell embryonic patterningMicroenvironmental patterning during sinoatrial node morphogenesis is critical for sustaining cardiac pacemaker cell function.
Expansion microscopy reveals subdomains in C. elegans germ granulesVisualising C. elegans germ granules using the super resolution technique expansion microscopy against the backdrop of proteome staining reveals granule ultrastructure.
The ADAM17 sheddase complex regulator iTAP/Frmd8 modulates inflammation and tumor growthThe FERM domain protein iTAP/Frmd8, which binds to and stabilizes the ADAM17/iRhom sheddase complex at the cell surface, is a regulator of inflammation, epithelial homeostasis, and tumor growth in vivo.