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Pharmacology & Biotechnology

  • Immunogenicity and effectiveness of an mRNA therapeutic vaccine for HPV-related malignancies
    Open Access
    Immunogenicity and effectiveness of an mRNA therapeutic vaccine for HPV-related malignancies

    Jing Wang, Ling Ma, Yunfeng Chen, Rui Zhou, Qixin Wang, Tingting Zhang, Dongrong Yi, Qian Liu, Yongxin Zhang, Weiguo Zhang, Yijie Dong, Shan Cen

    Jing Wang ... Shan Cen

    Published 21 March 2024

    mHTV-02 functions as a candidate effective therapeutic mRNA-LNP vaccine via intramuscular or intratumoral administration routes for treating malignancies caused by HPV16 or HPV18 infections.

  • A dual-targeted drug inhibits cardiac ryanodine receptor Ca<sup>2+</sup> leak but activates SERCA2a Ca<sup>2+</sup> uptake
    Open Access
    A dual-targeted drug inhibits cardiac ryanodine receptor Ca2+ leak but activates SERCA2a Ca2+ uptake

    Jörg W Wegener, Gyuzel Y Mitronova, Lina ElShareif, Christine Quentin, Vladimir Belov, Tatiana Pochechueva, Gerd Hasenfuss, Lutz Ackermann, Stephan E Lehnart

    Jörg W Wegener ... Stephan E Lehnart

    Published 27 November 2023

    Our study identified a first multi-targeted compound (GM1869) inhibiting RyR2-mediated Ca2+ leak together with activating SERCA2a function that may represent a critical breakthrough for treatment of diastolic Ca2+ leak in heart failure.

  • Rapid and precise genotyping of transgene zygosity in mice using an allele-specific method
    Open Access
    Rapid and precise genotyping of transgene zygosity in mice using an allele-specific method

    Jianqi Yang, Alison N DeVore, Daniel A Fu, Mackenzie M Spicer, Mengcheng Guo, Samantha G Thompson, Katelin E Ahlers-Dannen, Federica Polato, Andre Nussenzweig, Rory A Fisher

    Jianqi Yang ... Rory A Fisher

    Published 10 April 2023

    A novel, precise, rapid, and generalizable method to determine transgene zygosity in mice by allele-specific restriction enzyme digestion of PCR products from transgenes or homologous endogenous genes.

  • Cell death and barrier disruption by clinically used iodine concentrations
    Open Access
    Cell death and barrier disruption by clinically used iodine concentrations

    Anne Steins, Christina Carroll, Fui Jiun Choong, Amee J George, Jin-Shu He, Kate M Parsons, Shouya Feng, Si Ming Man, Cathelijne Kam, Lex M van Loon, Perlita Poh, Rita Ferreira, Graham J Mann, Russell L Gruen, Katherine M Hannan, Ross D Hannan, Klaus-Martin Schulte

    Anne Steins ... Klaus-Martin Schulte

    Published 21 March 2023

    Clinically used concentrations of povidone-iodine (PVP-I) are toxic to eukaryotic cells by attacking the lipid bilayer and tight junctions with fast kinetics and urge the reappraisal of PVP-I use.

  • Vasopressin V1a receptor and oxytocin receptor regulate murine sperm motility differently
    Open Access
    Vasopressin V1a receptor and oxytocin receptor regulate murine sperm motility differently

    Hiroyoshi Tsuchiya, Masakatsu Fujinoki, Morio Azuma, Taka-aki Koshimizu

    Hiroyoshi Tsuchiya ... Taka-aki Koshimizu

    Published 17 January 2023

    Epididymal vasopressin V1a receptor is involved in the regulation of sperm motility, and its antagonist may be a therapeutic agent for male-type reproductive dysfunction.

  • <em>PACSIN2</em> as a modulator of autophagy and mercaptopurine cytotoxicity: mechanisms in lymphoid and intestinal cells
    Open Access
    PACSIN2 as a modulator of autophagy and mercaptopurine cytotoxicity: mechanisms in lymphoid and intestinal cells

    Giulia Zudeh, Raffaella Franca, Marianna Lucafò, Erik J Bonten, Matteo Bramuzzo, Riccardo Sgarra, Cristina Lagatolla, Martina Franzin, William E Evans, Giuliana Decorti, Gabriele Stocco

    Giulia Zudeh ... Gabriele Stocco

    Published 3 January 2023

    This study evaluates the role of PACSIN2 in autophagy modulation and its impact on mercaptopurine cytotoxicity in lymphoid and intestinal models.

  • Visualized procollagen Iα1 demonstrates the intracellular processing of propeptides
    Open Access
    Visualized procollagen Iα1 demonstrates the intracellular processing of propeptides

    Toshiaki Tanaka, Koji Moriya, Makoto Tsunenaga, Takayo Yanagawa, Hiromi Morita, Takashi Minowa, Yoh-ichi Tagawa, Nobutaka Hanagata, Yutaka Inagaki, Toshiyuki Ikoma

    Toshiaki Tanaka ... Toshiyuki Ikoma

    Published 18 February 2022

    Procollagen Iα1 with two tags reveals the different fates of processed propeptides, the rate-limiting step in collagen secretion, and a link between defects in intracellular processing and diseases.

  • Preclinical and randomized phase I studies of plitidepsin in adults hospitalized with COVID-19
    Open Access
    Preclinical and randomized phase I studies of plitidepsin in adults hospitalized with COVID-19

    Jose F Varona, Pedro Landete, Jose A Lopez-Martin, Vicente Estrada, Roger Paredes, Pablo Guisado-Vasco, Lucia Fernandez de Orueta, Miguel Torralba, Jesus Fortun, Roberto Vates, Jose Barberan, Bonaventura Clotet, Julio Ancochea, Daniel Carnevali, Noemi Cabello, Lourdes Porras, Paloma Gijon, Alfonso Monereo, Daniel Abad, Sonia Zuñiga, Isabel Sola, Jordi Rodon, Julia Vergara-Alert, Nuria Izquierdo-Useros, Salvador Fudio, Maria Jose Pontes, Beatriz de Rivas, Patricia Giron de Velasco, Antonio Nieto, Javier Gomez, Pablo Aviles, Rubin Lubomirov, Alvaro Belgrano, Belen Sopesen, Kris M White, Romel Rosales, Soner Yildiz, Ann-Kathrin Reuschl, Lucy G Thorne, Clare Jolly, Greg J Towers, Lorena Zuliani-Alvarez, Mehdi Bouhaddou, Kirsten Obernier, Briana L McGovern, M Luis Rodriguez, Luis Enjuanes, Jose M Fernandez-Sousa, Nevan J Krogan, Jose M Jimeno, Adolfo Garcia-Sastre

    Jose F Varona ... Adolfo Garcia-Sastre

    Published 10 January 2022

    This proof-of-concept study shows that plitidepsin, a marine peptide that inhibits SARS-CoV-2 replication, has a favorable safety profile and may be an efficacious treatment for patients with COVID-19.

  • TPC2 promotes choroidal angiogenesis and inflammation in a mouse model of neovascular age-related macular degeneration
    Open Access
    TPC2 promotes choroidal angiogenesis and inflammation in a mouse model of neovascular age-related macular degeneration

    Yanfen Li, Christian Schön, Cheng-Chang Chen, Zhuo Yang, Raffael Liegl, Elisa Murenu, Benedikt Schworm, Norbert Klugbauer, Christian Grimm, Christian Wahl-Schott, Stylianos Michalakis, Martin Biel

    Yanfen Li ... Martin Biel

    Published 28 June 2021

    This study identifies the endolysosomal two-pore channel TPC2 as a potential novel drug target for age-related macular degeneration (AMD). Inhibition of TPC2 reduces two key clinical hallmarks of the AMD, retinal inflammation and formation of leaky choroi.

  • BRD2 regulation of sigma-2 receptor upon cholesterol deprivation
    Open Access
    BRD2 regulation of sigma-2 receptor upon cholesterol deprivation

    Hongtao Shen, Jing Li, Xiujie Xie, Huan Yang, Mengxue Zhang, Bowen Wang, K Craig Kent, Jorge Plutzky, Lian-Wang Guo

    Hongtao Shen ... Lian-Wang Guo

    Published 24 November 2020

    Upon cholesterol deprivation, epigenetic bookmark reader BRD2 and master transcription factor SREBP2 form a complex at bookmarked chromatin (H3K27ac), thereby activating the transcription of the sigma-2 receptor—a recently unveiled player in cholesterol homeostasis.

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