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Pharmacology & Biotechnology

  • BRD2 regulation of sigma-2 receptor upon cholesterol deprivation
    Open Access
    BRD2 regulation of sigma-2 receptor upon cholesterol deprivation

    Hongtao Shen, Jing Li, Xiujie Xie, Huan Yang, Mengxue Zhang, Bowen Wang, K Craig Kent, Jorge Plutzky, Lian-Wang Guo

    Hongtao Shen ... Lian-Wang Guo

    Published 24 November 2020

    Upon cholesterol deprivation, epigenetic bookmark reader BRD2 and master transcription factor SREBP2 form a complex at bookmarked chromatin (H3K27ac), thereby activating the transcription of the sigma-2 receptor—a recently unveiled player in cholesterol homeostasis.

  • The stress polarity signaling (SPS) pathway serves as a marker and a target in the leaky gut barrier: implications in aging and cancer
    Open Access
    The stress polarity signaling (SPS) pathway serves as a marker and a target in the leaky gut barrier: implications in aging and cancer

    Pradipta Ghosh, Lee Swanson, Ibrahim M Sayed, Yash Mittal, Blaze B Lim, Stella-Rita Ibeawuchi, Marc Foretz, Benoit Viollet, Debashis Sahoo, Soumita Das

    Pradipta Ghosh ... Soumita Das

    Published 10 February 2020

    Using patient-derived organoids the authors show how a specialized polarity pathway protects our gut barrier from stress-induced collapse. Findings highlight both diagnostic and therapeutic potential of the pathway for treating gut barrier dysfunction in aging, cancer, and dysbiosis.

  • Phenotypic proteomic profiling identifies a landscape of targets for circadian clock–modulating compounds
    Open Access
    Phenotypic proteomic profiling identifies a landscape of targets for circadian clock–modulating compounds

    Sandipan Ray, Radoslaw Lach, Kate J Heesom, Utham K Valekunja, Vesela Encheva, Ambrosius P Snijders, Akhilesh B Reddy

    Sandipan Ray ... Akhilesh B Reddy

    Published 2 December 2019

    This study provides comprehensive insights into the mechanism of action and cellular effects of circadian period–modulating compounds, which is critical for clearly defining molecular targets to modulate daily rhythms for therapeutic benefit.

  • ADAPTABLE: a comprehensive web platform of antimicrobial peptides tailored to the user’s research
    Open Access
    ADAPTABLE: a comprehensive web platform of antimicrobial peptides tailored to the user’s research

    Francisco Ramos-Martín, Thibault Annaval, Sébastien Buchoux, Catherine Sarazin, Nicola D’Amelio

    Francisco Ramos-Martín ... Nicola D’Amelio

    Published 18 November 2019

    ADAPTABLE is a webserver and database of antimicrobial peptides that uses sequence and property alignment to highlight their mode of action against the threat of resistance in medicine and agriculture.

  • Engineering <em>Photorhabdus luminescens</em> toxin complex (PTC) into a recombinant injection nanomachine
    Open Access
    Engineering Photorhabdus luminescens toxin complex (PTC) into a recombinant injection nanomachine

    Peter Njenga Ng´ang´a, Julia K Ebner, Matthias Plessner, Klaus Aktories, Gudula Schmidt

    Peter Njenga Ng´ang´a ... Gudula Schmidt

    Published 20 September 2019

    The article shows successful engineering of the syringe-like injection apparatus of Photorhabdus luminescens as standalone nanomachine for delivery of protein toxins and enzymes from different species into mammalian cells.

  • A molecule inducing androgen receptor degradation and selectively targeting prostate cancer cells
    Open Access
    A molecule inducing androgen receptor degradation and selectively targeting prostate cancer cells

    Serge Auvin, Harun Öztürk, Yusuf T Abaci, Gisele Mautino, Florence Meyer-Losic, Florence Jollivet, Tarig Bashir, Hugues de Thé, Umut Sahin

    Serge Auvin ... Umut Sahin

    Published 20 August 2019

    A new molecule induces AR sumoylation and degradation resulting in selective growth inhibition in AR-dependent prostate cancer cells, but its activity is blunted by interference with proteasomes.

  • Tamoxifen blocks retrograde trafficking of Shiga toxin 1 and 2 and protects against lethal toxicosis
    Open Access
    Tamoxifen blocks retrograde trafficking of Shiga toxin 1 and 2 and protects against lethal toxicosis

    Andrey S Selyunin, Steven Hutchens, Stanton F McHardy, Somshuvra Mukhopadhyay

    Andrey S Selyunin ... Somshuvra Mukhopadhyay

    Published 26 June 2019

    This study reports an unexpected role of late endosome–lysosome fusion in early endosome-to-Golgi trafficking of Shiga toxins and identifies tamoxifen to be a potent inhibitor of Shiga toxicosis.

  • Vamorolone targets dual nuclear receptors to treat inflammation and dystrophic cardiomyopathy
    Open Access
    Vamorolone targets dual nuclear receptors to treat inflammation and dystrophic cardiomyopathy

    Christopher R Heier, Qing Yu, Alyson A Fiorillo, Christopher B Tully, Asya Tucker, Davi A Mazala, Kitipong Uaesoontrachoon, Sadish Srinivassane, Jesse M Damsker, Eric P Hoffman, Kanneboyina Nagaraju, Christopher F Spurney

    Christopher R Heier ... Christopher F Spurney

    Published 11 February 2019

    Vamorolone is a first-in-class dissociative drug that selectively targets the glucocorticoid receptor to safely treat chronic inflammation and the mineralocorticoid receptor to treat cardiomyopathy, providing efficacy with improved safety in mouse models of Duchenne muscular dystrophy.

  • Aging (11)
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  • Genetics, Gene Therapy & Genetic Disease (33)
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  • Medical Research (31)
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  • Microbiology, Virology & Host Pathogen Interaction (47)
  • Molecular Biology (102)
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  • Neuroscience (39)
  • Pharmacology & Biotechnology (8)
  • Physiology (11)
  • Plant Science (11)
  • Stem Cells (26)
  • Structural Biology (28)
  • Synthetic Biology (2)
  • Systems & Computational Biology (38)
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