Neuroscience
- Integrin β1/FAK/SRC signal pathway is involved in autism spectrum disorder in Tspan7 knockout rats
TSPAN7 knockout causes ASD-like phenotypes in rats through the integrin β1/FAK/SRC signal pathway, which provides novel insights into the role of TSPAN7 in psychiatric diseases, highlighting SRC as a potential target.
- Correction: Building in vitro models of the brain to understand the role of APOE in Alzheimer’s disease
Human induced pluripotent stem cell (hiPSC)–based models of the brain will be key to unraveling the role of APOE ɛ4 in the interconnected cellular changes underlying Alzheimer’s disease.
- DSCR1 deficiency ameliorates the Aβ pathology of Alzheimer’s disease by enhancing microglial activity
The authors suggested that an important role of Down syndrome critical region 1 (DSCR1) in microglial activation is to provide a potential therapeutic target for microglial Aβ clearance in Alzheimer’s disease.
- Loss of NDR1/2 kinases impairs endomembrane trafficking and autophagy leading to neurodegeneration
NDR1/2 kinases are essential for efficient endocytosis and protein clearance by autophagy. Neuron-specific dual deletion of NDR1 and NDR2 causes cortical and hippocampal neurodegeneration, implicating these kinases in neuronal protein homeostasis and health.
- Synergistic activation of RARβ and RARγ nuclear receptors restores cell specialization during stem cell differentiation by hijacking RARα-controlled programs
Synergistic activation of RARβ and RARγ nuclear receptors in mouse stem cells restores cell specialization during neuronal differentiation by hijacking RARα-controlled programs.
- SMA-linked SMN mutants prevent phase separation properties and SMN interactions with FMRP family members
The survival motor neuron (SMN) protein associates with translation regulators and phase-separates into RNA-stabilized droplets that are likely candidates for the formation of nuclear and cytoplasmic membraneless organelles.
- CRISPRi screening reveals regulators of tau pathology shared between exosomal and vesicle-free tau
Using a genome-wide CRISPRi screen, we identified ANKLE2, BANF1, NUSAP1, EIF1AD, and VPS18 as novel regulators of tau pathology induced by both exosome-like extracellular vesicles and free tau seeds.
- Autoimmune RNA dysregulation and seizures: therapeutic prospects in neuropsychiatric lupus
Lupus autoantibodies directed at neuroregulatory BC200 RNA cause seizure susceptibility in mice, but sequestration with antigen prevents seizures, indicating utility in therapeutic interventions.
- Translatome profiling in fatal familial insomnia implicates TOR signaling in somatostatin neurons
Bauer and colleagues report that among the six neuron types studied, somatostatin neurons have an unexpectedly strong and similar response to two distinct genetic prion diseases before disease onset.
- Timapiprant, a prostaglandin D2 receptor antagonist, ameliorates pathology in a rat Alzheimer’s model
PGD2 is a major brain prostaglandin and we report that timapiprant that is an antagonist for the PGD2 receptor DP2 reduces pathology and cognitive deficits in a transgenic rat model of Alzheimer’s.