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Neuroscience

  • Neuron-specific inactivation of <em>Wt1</em> alters locomotion in mice and changes interneuron composition in the spinal cord
    Open Access
    Neuron-specific inactivation of Wt1 alters locomotion in mice and changes interneuron composition in the spinal cord

    Danny Schnerwitzki, Sharn Perry, Anna Ivanova, Fabio V Caixeta, Paul Cramer, Sven Günther, Kathrin Weber, Atieh Tafreshiha, Lore Becker, Ingrid L Vargas Panesso, Thomas Klopstock, Martin Hrabe de Angelis, Manuela Schmidt, Klas Kullander, Christoph Englert

    Danny Schnerwitzki ... Christoph Englert

    Published 16 August 2018

    This work demonstrates a role for the Wilms tumor protein Wt1 in the specification of neurons that are involved in the control of locomotion.

  • JIP2 haploinsufficiency contributes to neurodevelopmental abnormalities in human pluripotent stem cell–derived neural progenitors and cortical neurons
    Open Access
    JIP2 haploinsufficiency contributes to neurodevelopmental abnormalities in human pluripotent stem cell–derived neural progenitors and cortical neurons

    Reinhard Roessler, Johanna Goldmann, Chikdu Shivalila, Rudolf Jaenisch

    Reinhard Roessler ... Rudolf Jaenisch

    Published 25 June 2018

    Molecular and cellular profiling of patient-specific neural cell types provides suggestions for the involvement of JIP2 in the neurodevelopmental disorder Phelan–McDermid syndrome.

  • Neuronal Aβ42 is enriched in small vesicles at the presynaptic side of synapses
    Open Access
    Neuronal Aβ42 is enriched in small vesicles at the presynaptic side of synapses

    Yang Yu, Daniel C Jans, Bengt Winblad, Lars O Tjernberg, Sophia Schedin-Weiss

    Yang Yu ... Sophia Schedin-Weiss

    Published 14 June 2018

    Super-resolution microscopy reveals that Aβ42 is mainly present at the presynaptic side of the synapse.

  • Proteomics and <em>C9orf72</em> neuropathology identify ribosomes as poly-GR/PR interactors driving toxicity
    Open Access
    Proteomics and C9orf72 neuropathology identify ribosomes as poly-GR/PR interactors driving toxicity

    Hannelore Hartmann, Daniel Hornburg, Mareike Czuppa, Jakob Bader, Meike Michaelsen, Daniel Farny, Thomas Arzberger, Matthias Mann, Felix Meissner, Dieter Edbauer

    Hannelore Hartmann ... Dieter Edbauer

    Published 16 May 2018

    Proteomics and neuropathological validation show that aberrant poly-GR/PR proteins in C9orf72 ALS/FTD bind STAU2 and ribosomes and inhibit translation.

  • BACE2 distribution in major brain cell types and identification of novel substrates
    Open Access
    BACE2 distribution in major brain cell types and identification of novel substrates

    Iryna Voytyuk, Stephan A Mueller, Julia Herber, An Snellinx, Dieder Moechars, Geert van Loo, Stefan F Lichtenthaler, Bart De Strooper

    Iryna Voytyuk ... Bart De Strooper

    Published 15 February 2018

    β-Site APP-cleaving enzyme 1 (BACE1) inhibition to treat Alzheimer’s disease also inhibits BACE2. This work shows BACE2 expression in the mouse brain and identifies its substrates. Increased BACE2 processing of vascular cell adhesion molecule 1 during inflammatory conditions cautions the use of current nonspecific BACE1 inhibitors in the clinic.

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