Neuroscience
Neuron-specific inactivation of Wt1 alters locomotion in mice and changes interneuron composition in the spinal cordThis work demonstrates a role for the Wilms tumor protein Wt1 in the specification of neurons that are involved in the control of locomotion.
JIP2 haploinsufficiency contributes to neurodevelopmental abnormalities in human pluripotent stem cell–derived neural progenitors and cortical neuronsMolecular and cellular profiling of patient-specific neural cell types provides suggestions for the involvement of JIP2 in the neurodevelopmental disorder Phelan–McDermid syndrome.
Neuronal Aβ42 is enriched in small vesicles at the presynaptic side of synapsesSuper-resolution microscopy reveals that Aβ42 is mainly present at the presynaptic side of the synapse.
Proteomics and C9orf72 neuropathology identify ribosomes as poly-GR/PR interactors driving toxicityProteomics and neuropathological validation show that aberrant poly-GR/PR proteins in C9orf72 ALS/FTD bind STAU2 and ribosomes and inhibit translation.
BACE2 distribution in major brain cell types and identification of novel substratesβ-Site APP-cleaving enzyme 1 (BACE1) inhibition to treat Alzheimer’s disease also inhibits BACE2. This work shows BACE2 expression in the mouse brain and identifies its substrates. Increased BACE2 processing of vascular cell adhesion molecule 1 during inflammatory conditions cautions the use of current nonspecific BACE1 inhibitors in the clinic.