Neuroscience
- Neuron-specific inactivation of Wt1 alters locomotion in mice and changes interneuron composition in the spinal cord
This work demonstrates a role for the Wilms tumor protein Wt1 in the specification of neurons that are involved in the control of locomotion.
- JIP2 haploinsufficiency contributes to neurodevelopmental abnormalities in human pluripotent stem cell–derived neural progenitors and cortical neurons
Molecular and cellular profiling of patient-specific neural cell types provides suggestions for the involvement of JIP2 in the neurodevelopmental disorder Phelan–McDermid syndrome.
- Neuronal Aβ42 is enriched in small vesicles at the presynaptic side of synapses
Super-resolution microscopy reveals that Aβ42 is mainly present at the presynaptic side of the synapse.
- Proteomics and C9orf72 neuropathology identify ribosomes as poly-GR/PR interactors driving toxicity
Proteomics and neuropathological validation show that aberrant poly-GR/PR proteins in C9orf72 ALS/FTD bind STAU2 and ribosomes and inhibit translation.
- BACE2 distribution in major brain cell types and identification of novel substrates
β-Site APP-cleaving enzyme 1 (BACE1) inhibition to treat Alzheimer’s disease also inhibits BACE2. This work shows BACE2 expression in the mouse brain and identifies its substrates. Increased BACE2 processing of vascular cell adhesion molecule 1 during inflammatory conditions cautions the use of current nonspecific BACE1 inhibitors in the clinic.