Neuroscience
- MicroRNAs in tear fluids predict underlying molecular changes associated with Alzheimer’s disease
This study demonstrated the translational potential of deregulated tear fluid miRNAs associated with amyloid beta production and proinflammation in a transgenic AD mouse model.
- The TUDOR domain of SMN is an H3K79me1 histone mark reader
The survival of motor neuron (SMN) protein is depleted in spinal muscular atrophy (SMA) pathology and herein defined as the first reader of histone H3 mono-methylated on lysine 79 through its central TUDOR domain.
- A multiplexed siRNA screen identifies key kinase signaling networks of brain glia
This study reports a multiplexed brain glial kinase screen, providing insight into the largely unknown glial intracellular signaling networks controlling neuroinflammation and highlights the therapeutic potential of targeting glial kinases to modulate glial phenotypes and treat neuroinflammatory disorders.
- The ribose methylation enzyme FTSJ1 has a conserved role in neuron morphology and learning performance
This study adds insights into FTSJ1 tRNA 2′-O-methylation–associated pathologies in humans and Drosophila by identification of novel FTSJ1 targets and neuron morphology defects.
- SorCS1 inhibits amyloid-β binding to neurexin and rescues amyloid-β–induced synaptic pathology
The protein sorting receptor SorCS1 shields the synapse organizer β-neurexins from amyloid-β oligomers (AβOs) to alleviate AβO-induced synaptic pathology.
- Membrane cholesterol regulates inhibition and substrate transport by the glycine transporter, GlyT2
Cholesterol binds to the GlyT2 SLC6 transporter, enhancing the effect of bioactive lipid analgesics, providing new therapeutic avenues to treat neuropathic pain and target SLC6 transporters.
- SMN promotes mitochondrial metabolic maturation during myogenesis by regulating the MYOD-miRNA axis
SMN contributes to muscle maturation by binding to the promoter regions of MYOD1 and miRNAs and regulating the expression of these molecules during myogenesis.
- Unconventional interactions of the TRPV4 ion channel with beta-adrenergic receptor ligands
The transient receptor potential vanilloid (TRPV4) ion channel is important for respiratory function. Here, it is shown that TRPV4 is inhibited by bronchodilators widely used in diseases such as asthma.
- Branch point strength controls species-specific CAMK2B alternative splicing and regulates LTP
A mechanism that contributes to species-specific alternative splicing leading to increased coding capacity of primate genomes is presented and functionality for CamK2β splicing addressed.
- Integrin ligands block mechanical signal transduction in baroreceptors
The binding of integrins to specific sequences in extracellular matrix forms the mechanical coupling to transfer stretch applied on the vascular wall to the baroreceptors.