Neuroscience
- Peripheral immune system modulates Purkinje cell degeneration in Niemann–Pick disease type C1
We demonstrate that peripheral immune cells are involved in the cerebral neuronal degeneration in Niemann–Pick disease type C1. Our work can contribute to a novel therapeutic strategy that can potentially be combined with the ongoing lipid reduction therapeutic efforts.
- Toxicity of C9orf72-associated dipeptide repeat peptides is modified by commonly used protein tags
Protein tags affect the toxicity of C9orf72-associated dipeptide repeat proteins and therefore should be avoided in preclinical models of C9orf72 ALS and FTD.
- MiR-93-5p inhibits retinal neurons apoptosis by regulating PDCD4 in acute ocular hypertension model
It is found that miR-93-5p decreases retinal neuron apoptosis through suppressing PDCD4 in acute ocular hypertension model, which indicates miR-93-5p as a therapeutic target of glaucoma.
- Preeclampsia promotes autism in offspring via maternal inflammation and fetal NFκB signaling
This study highlights elevated TNFα in maternal serum contributes to autism-like phenotypes in offspring exposed to preeclampsia and gives a therapeutic target to prevent it.
- Apolipoprotein E intersects with amyloid-β within neurons
Apolipoprotein E4, the most important genetic risk factor for Alzheimer's disease, is shown to internalize into neurons and intersect with amyloid-β in endosomes–autophagosomes of neurites and modulate intraneuronal amyloid-β-42.
- SIRT6 overexpression in the nucleus protects mouse retinal pigment epithelium from oxidative stress
Oxidative stress causes a rapid translocation of SIRT6 from the nucleus to the cytoplasm leading to nuclear SIRT6 depletion and results in RPE damage that is more severe in the central region in mice.
- Cognitive decline in diabetic mice predisposed to Alzheimer’s disease is greater than in wild type
This work proposes that T2DM is particularly harmful to brain function in individuals with a genetic predisposition to neurodegenerative pathology via, among others, γ-secretase inhibition.
- New botulinum neurotoxin constructs for treatment of chronic pain
A new technique to make therapeutic botulinum neurotoxins via isopeptide bonding is described. The novel elongated botulinum neurotoxin can treat nerve injury pain without causing muscle paralysis.
- Bats experience age-related hearing loss (presbycusis)
Bats exhibited age-related hearing loss. Bats are exposed to immense conspecific noise, but the frequency-dependent hearing loss was not correlated to the noise.
- Structure-based design and characterization of Parkin-activating mutations
Parkin, an E3 ubiquitin ligase involved in Parkinson’s disease, is inactive in the basal state and is activated by PINK1 to mediate mitophagy. Here, we characterized 31 mutations and discovered three that activate Parkin and rescue loss of PINK1 phosphorylation.