Neuroscience
Regulation of proteostasis by sleep through autophagy in Drosophila models of Alzheimer’s diseaseSleep modulation alters Tau-induced neurodegeneration in Drosophila models of tauopathy.
mTORC1 hampers Hedgehog signaling in Tsc2 deficient cellsThis is the first demonstration that mTORC1 inhibits Hedgehog signaling. mTORC1 prevents cilia accumulation of Smo and activation of GlI2. Also, evidence is provided for a 2-step activation process of GLI2.
CC2D1A causes ciliopathy, intellectual disability, heterotaxy, renal dysplasia, and abnormal CSF flowThis report identifies two novel CC2D1A variants in patients with intellectual disability. Functional analysis in multiple model systems reveals CC2D1A’s critical role in ciliogenesis and CSF circulation.
Morphological correlates of synaptic protein turnover in the mouse brainSynapse size, vesicle numbers, or the presence of a nascent zone, are indicators for the metabolic age of the synapse, in both young adult and old mice.
Distribution of lipid droplets in hippocampal neurons and microglia: impact of diabetes and exerciseLipid droplets (LDs) are differently distributed in the CA1 and CA3 of the mouse hippocampus, and even along the CA3. Diabetes increased microglial LDs, suggesting a neurodegenerative mechanism, which is modestly affected by high-intensity exercise.
Fasting-induced activity changes in MC3R neurons of the paraventricular nucleus of the thalamusThis study assesses how the brain responds to fasting and the role of melanocortin 3 receptor neurons within the paraventricular nucleus of the thalamus, measured using immunohistochemistry, microscopy, chemogenetics, and behavioral analysis.
Differential roles of lysosomal cholesterol transporters in the development of C. elegans NMJsNeuronal cholesterol homeostasis during synapse development is controlled by two NPC1 homologs in C. elegans: NCR-1 absorbs cholesterol and promotes synaptogenesis, whereas NCR-2 uses cholesterol and hinders synaptogenesis.
Global huntingtin knockout in adult mice leads to fatal neurodegeneration that spares the pancreasRecent reports on the consequences of global HTT knock-out have discrepant findings. We confirm here that early loss of HTT leads to subcortical calcification, which is preceded by induction of circulating neurofilament light chain levels, but find no pancreatitis.
c-KIT inhibitors reduce pathology and improve behavior in the Tg(SwDI) model of Alzheimer’s diseaseBrain-penetrant c-KIT inhibitors, BK40143 and BK4019,7 regulate harmonious mechanisms via autophagy and regulation of mast-cell-microglial communication and improve cognition in Alzheimer’s models.
HB-EGF activates EGFR to induce reactive neural stem cells in the mouse hippocampus after seizuresBlocking epidermal growth factor receptor signaling after seizures prevents the induction of reactive neural stem cells and preserves neurogenesis in the hippocampus of mice.