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Neuroscience

  • SIRT6 overexpression in the nucleus protects mouse retinal pigment epithelium from oxidative stress
    Open Access
    SIRT6 overexpression in the nucleus protects mouse retinal pigment epithelium from oxidative stress

    Xue Yang, Jin-Yong Chung, Usha Rai, Noriko Esumi

    Xue Yang ... Noriko Esumi

    Published 25 April 2023

    Oxidative stress causes a rapid translocation of SIRT6 from the nucleus to the cytoplasm leading to nuclear SIRT6 depletion and results in RPE damage that is more severe in the central region in mice.

  • Cognitive decline in diabetic mice predisposed to Alzheimer’s disease is greater than in wild type
    Open Access
    Cognitive decline in diabetic mice predisposed to Alzheimer’s disease is greater than in wild type

    Marta Carús-Cadavieco, Inés Berenguer López, Alba Montoro Canelo, Miguel A Serrano-Lope, Sandra González-de la Fuente, Begoña Aguado, Alba Fernández-Rodrigo, Takaomi C Saido, Ana Frank García, César Venero, José A Esteban, Francesc Guix, Carlos G Dotti

    Marta Carús-Cadavieco ... Carlos G Dotti

    Published 14 April 2023

    This work proposes that T2DM is particularly harmful to brain function in individuals with a genetic predisposition to neurodegenerative pathology via, among others, γ-secretase inhibition.

  • New botulinum neurotoxin constructs for treatment of chronic pain
    Open Access
    New botulinum neurotoxin constructs for treatment of chronic pain

    Charlotte Leese, Claire Christmas, Judit Mészáros, Stephanie Ward, Maria Maiaru, Stephen P Hunt, Bazbek Davletov

    Charlotte Leese ... Bazbek Davletov

    Published 11 April 2023

    A new technique to make therapeutic botulinum neurotoxins via isopeptide bonding is described. The novel elongated botulinum neurotoxin can treat nerve injury pain without causing muscle paralysis.

  • Bats experience age-related hearing loss (presbycusis)
    Open Access
    Bats experience age-related hearing loss (presbycusis)

    Yifat Chaya Tarnovsky, Shahar Taiber, Yomiran Nissan, Arjan Boonman, Yaniv Assaf, Gerald S Wilkinson, Karen B Avraham, Yossi Yovel

    Yifat Chaya Tarnovsky ... Yossi Yovel

    Published 30 March 2023

    Bats exhibited age-related hearing loss. Bats are exposed to immense conspecific noise, but the frequency-dependent hearing loss was not correlated to the noise.

  • Structure-based design and characterization of Parkin-activating mutations
    Open Access
    Structure-based design and characterization of Parkin-activating mutations

    Michael U Stevens, Nathalie Croteau, Mohamed A Eldeeb, Odetta Antico, Zhi Wei Zeng, Rachel Toth, Thomas M Durcan, Wolfdieter Springer, Edward A Fon, Miratul MK Muqit, Jean-François Trempe

    Michael U Stevens ... Jean-François Trempe

    Published 20 March 2023

    Parkin, an E3 ubiquitin ligase involved in Parkinson’s disease, is inactive in the basal state and is activated by PINK1 to mediate mitophagy. Here, we characterized 31 mutations and discovered three that activate Parkin and rescue loss of PINK1 phosphorylation.

  • MicroRNAs in tear fluids predict underlying molecular changes associated with Alzheimer’s disease
    Open Access
    MicroRNAs in tear fluids predict underlying molecular changes associated with Alzheimer’s disease

    Printha Wijesinghe, Jeanne Xi, Jing Cui, Matthew Campbell, Wellington Pham, Joanne A Matsubara

    Printha Wijesinghe ... Joanne A Matsubara

    Published 20 March 2023

    This study demonstrated the translational potential of deregulated tear fluid miRNAs associated with amyloid beta production and proinflammation in a transgenic AD mouse model.

  • The TUDOR domain of SMN is an H3K79<sup>me1</sup> histone mark reader
    Open Access
    The TUDOR domain of SMN is an H3K79me1 histone mark reader

    Olivier Binda, Aimé Boris Kimenyi Ishimwe, Maxime Galloy, Karine Jacquet, Armelle Corpet, Amélie Fradet-Turcotte, Jocelyn Côté, Patrick Lomonte

    Olivier Binda ... Patrick Lomonte

    Published 7 March 2023

    The survival of motor neuron (SMN) protein is depleted in spinal muscular atrophy (SMA) pathology and herein defined as the first reader of histone H3 mono-methylated on lysine 79 through its central TUDOR domain.

  • A multiplexed siRNA screen identifies key kinase signaling networks of brain glia
    Open Access
    A multiplexed siRNA screen identifies key kinase signaling networks of brain glia

    Jong-Heon Kim, Jin Han, Ruqayya Afridi, Jae-Hong Kim, Md Habibur Rahman, Dong Ho Park, Won Suk Lee, Gyun Jee Song, Kyoungho Suk

    Jong-Heon Kim ... Kyoungho Suk

    Published 6 March 2023

    This study reports a multiplexed brain glial kinase screen, providing insight into the largely unknown glial intracellular signaling networks controlling neuroinflammation and highlights the therapeutic potential of targeting glial kinases to modulate glial phenotypes and treat neuroinflammatory disorders.

  • The ribose methylation enzyme FTSJ1 has a conserved role in neuron morphology and learning performance
    Open Access
    The ribose methylation enzyme FTSJ1 has a conserved role in neuron morphology and learning performance

    Mira Brazane, Dilyana G Dimitrova, Julien Pigeon, Chiara Paolantoni, Tao Ye, Virginie Marchand, Bruno Da Silva, Elise Schaefer, Margarita T Angelova, Zornitza Stark, Martin Delatycki, Tracy Dudding-Byth, Jozef Gecz, Pierre-Yves Plaçais, Laure Teysset, Thomas Préat, Amélie Piton, Bassem A Hassan, Jean-Yves Roignant, Yuri Motorin, Clément Carré

    Mira Brazane ... Clément Carré

    Published 31 January 2023

    This study adds insights into FTSJ1 tRNA 2′-O-methylation–associated pathologies in humans and Drosophila by identification of novel FTSJ1 targets and neuron morphology defects.

  • SorCS1 inhibits amyloid-β binding to neurexin and rescues amyloid-β–induced synaptic pathology
    Open Access
    SorCS1 inhibits amyloid-β binding to neurexin and rescues amyloid-β–induced synaptic pathology

    Alfred Kihoon Lee, Nayoung Yi, Husam Khaled, Benjamin Feller, Hideto Takahashi

    Alfred Kihoon Lee ... Hideto Takahashi

    Published 25 January 2023

    The protein sorting receptor SorCS1 shields the synapse organizer β-neurexins from amyloid-β oligomers (AβOs) to alleviate AβO-induced synaptic pathology.

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