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Molecular Biology

  • MBNL1 alternative splicing isoforms play opposing roles in cancer
    Open Access
    MBNL1 alternative splicing isoforms play opposing roles in cancer

    Tommaso Tabaglio, Diana HP Low, Winnie Koon Lay Teo, Pierre Alexis Goy, Piotr Cywoniuk, Heike Wollmann, Jessica Ho, Damien Tan, Joey Aw, Andrea Pavesi, Krzysztof Sobczak, Dave Keng Boon Wee, Ernesto Guccione

    Tommaso Tabaglio ... Ernesto Guccione

    Published 7 September 2018

    MBNL1 proteins lacking exon 7 (−ex7) are antisurvival factors with tumor suppressive role that cancer cells tend to down-regulate in favor of MBNL +ex7 isoforms.

  • Distinctive features of lincRNA gene expression suggest widespread RNA-independent functions
    Open Access
    Distinctive features of lincRNA gene expression suggest widespread RNA-independent functions

    Alex C Tuck, Kedar Nath Natarajan, Greggory M Rice, Jason Borawski, Fabio Mohn, Aneliya Rankova, Matyas Flemr, Alice Wenger, Razvan Nutiu, Sarah Teichmann, Marc Bühler

    Alex C Tuck ... Marc Bühler

    Published 31 July 2018

    Combining single-cell RNA-seq of mouse ESCs and NPCs, lincRNA gene deletions, conditional RNA depletion, and nuclear exosome profiling distinguishes RNA-dependent and RNA-independent lincRNA gene activities.

  • Proteins of generalist and specialist pathogens differ in their amino acid composition
    Open Access
    Proteins of generalist and specialist pathogens differ in their amino acid composition

    Luz P Blanco, Bryan L Payne, Felix Feyertag, David Alvarez-Ponce

    Luz P Blanco ... David Alvarez-Ponce

    Published 17 July 2018

    Primitive amino acids and disorder content in secreted proteins are distinctively enriched in generalist compared with host-specific pathogens.

  • Role of <em>Cnot6l</em> in maternal mRNA turnover
    Open Access
    Role of Cnot6l in maternal mRNA turnover

    Filip Horvat, Helena Fulka, Radek Jankele, Radek Malik, Ma Jun, Katerina Solcova, Radislav Sedlacek, Kristian Vlahovicek, Richard M Schultz, Petr Svoboda

    Filip Horvat ... Petr Svoboda

    Published 16 July 2018

    Mice lacking Cnot6l, a deadenylase component of the CCR4–NOT complex, are viable, but females have ∼40% smaller litters. Cnot6l is a maternal-effect gene acting in maternal mRNA degradation.

  • Dynamic m<sup>6</sup>A methylation facilitates mRNA triaging to stress granules
    Open Access
    Dynamic m6A methylation facilitates mRNA triaging to stress granules

    Maximilian Anders, Irina Chelysheva, Ingrid Goebel, Timo Trenkner, Jun Zhou, Yuanhui Mao, Silvia Verzini, Shu-Bing Qian, Zoya Ignatova

    Maximilian Anders ... Zoya Ignatova

    Published 3 July 2018

    m6A modification in the 5′ vicinity of the coding sequence of transcripts provides a selective mechanism for triaging mRNAs to stress granules and is mediated by the YTHDF3 “reader” protein.

  • DNA polymerase ζ deficiency causes impaired wound healing and stress-induced skin pigmentation
    Open Access
    DNA polymerase ζ deficiency causes impaired wound healing and stress-induced skin pigmentation

    Sabine S Lange, Sarita Bhetawal, Shelley Reh, Katherine Leslie Powell, Donna F Kusewitt, Richard D Wood

    Sabine S Lange ... Richard D Wood

    Published 29 June 2018

    Mice harboring DNA polymerase ζ–defective keratinocytes are shown to have a defect in wound healing and a striking p53-dependent migration of melanocytes to the skin following UV radiation or wounding.

  • Molecular analysis of human Ero1 reveals novel regulatory mechanisms for oxidative protein folding
    Open Access
    Molecular analysis of human Ero1 reveals novel regulatory mechanisms for oxidative protein folding

    Antti Moilanen, Kati Korhonen, Mirva J Saaranen, Lloyd W Ruddock

    Antti Moilanen ... Lloyd W Ruddock

    Published 26 June 2018

    This study reveals novel regulatory mechanisms for human Ero1α and Ero1β, including cooperativity for oxygen binding and complex formation with PDI via a novel mixed disulfide linkage.

  • Somatic role of SYCE2: an insulator that dissociates HP1α from H3K9me3 and potentiates DNA repair
    Open Access
    Somatic role of SYCE2: an insulator that dissociates HP1α from H3K9me3 and potentiates DNA repair

    Noriko Hosoya, Masato Ono, Kiyoshi Miyagawa

    Noriko Hosoya ... Kiyoshi Miyagawa

    Published 22 June 2018

    This study reveals that the synaptonemal complex protein SYCE2 potentiates ataxia telangiectasia mutated–mediated DNA double-strand break repair by dissociating HP1α from trimethylated histone H3 lysine 9 in somatic cells.

  • Recruitment of ubiquitin-activating enzyme UBA1 to DNA by poly(ADP-ribose) promotes ATR signalling
    Open Access
    Recruitment of ubiquitin-activating enzyme UBA1 to DNA by poly(ADP-ribose) promotes ATR signalling

    Ramhari Kumbhar, Sophie Vidal-Eychenié, Dimitrios-Georgios Kontopoulos, Marion Larroque, Christian Larroque, Jihane Basbous, Sofia Kossida, Cyril Ribeyre, Angelos Constantinou

    Ramhari Kumbhar ... Angelos Constantinou

    Published 21 June 2018

    Human but not yeast UBA1 binds poly(ADP-ribose) polymers via a solvent-exposed and positively charged patch. Poly(ADP-ribose) polymerase 1–dependent recruitment of UBA1 to DNA ensures ataxia-telangiectasia and RAD3-related activation.

  • Chronic platelet-derived growth factor receptor signaling exerts control over initiation of protein translation in glioma
    Open Access
    Chronic platelet-derived growth factor receptor signaling exerts control over initiation of protein translation in glioma

    Shuang Zhou, Vicky A Appleman, Christopher M Rose, Hyun Jung Jun, Juechen Yang, Yue Zhou, Roderick T Bronson, Steve P Gygi, Al Charest

    Shuang Zhou ... Al Charest

    Published 19 June 2018

    Using phospho-proteomics in a new model of malignant glioma, we reveal that clinically relevant, chronic PDGFRα signaling differs considerably from acute receptor stimulation and unveils previously unrecognized control over key elements of the translation initiation machinery.

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