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Molecular Biology

  • Dual role of a GTPase conformational switch for membrane fusion by mitofusin ubiquitylation
    Open Access
    Dual role of a GTPase conformational switch for membrane fusion by mitofusin ubiquitylation

    Ramona Schuster, Vincent Anton, Tânia Simões, Selver Altin, Fabian den Brave, Thomas Hermanns, Manuela Hospenthal, David Komander, Gunnar Dittmar, R Jürgen Dohmen, Mafalda Escobar-Henriques

    Ramona Schuster ... Mafalda Escobar-Henriques

    Published 19 December 2019

    Mitochondrial fusion requires a conformational change in α4 of the GTPase domain, followed by AAA-ATPase regulation, thus revealing striking mechanistic similarities between small and large GTPases.

  • Expression of AXL receptor tyrosine kinase relates to monocyte dysfunction and severity of cirrhosis
    Open Access
    Expression of AXL receptor tyrosine kinase relates to monocyte dysfunction and severity of cirrhosis

    Robert Brenig, Oltin T Pop, Evangelos Triantafyllou, Anne Geng, Arjuna Singanayagam, Christian Perez-Shibayama, Lenka Besse, Jovana Cupovic, Patrizia Künzler, Tuyana Boldanova, Stephan Brand, David Semela, François HT Duong, Christopher J Weston, Burkhard Ludewig, Markus H Heim, Julia Wendon, Charalambos G Antoniades, Christine Bernsmeier

    Robert Brenig ... Christine Bernsmeier

    Published 10 December 2019

    Immune dysfunction determines morbidity and mortality in liver cirrhosis. Distinct AXL-expressing circulating monocytes, which regulate antimicrobial responses, expand with progression of the disease.

  • Refining the adipose progenitor cell landscape in healthy and obese visceral adipose tissue using single-cell gene expression profiling
    Open Access
    Refining the adipose progenitor cell landscape in healthy and obese visceral adipose tissue using single-cell gene expression profiling

    Dong Seong Cho, Bolim Lee, Jason D Doles

    Dong Seong Cho ... Jason D Doles

    Published 25 November 2019

    This work dissects adipose progenitor cell (APC) heterogeneity in normal and obese adipose tissue using single-cell expression profiling. Novel APC subpopulations are identified and characterized.

  • Plasticity in salt bridge allows fusion-competent ubiquitylation of mitofusins and Cdc48 recognition
    Open Access
    Plasticity in salt bridge allows fusion-competent ubiquitylation of mitofusins and Cdc48 recognition

    Vincent Anton, Ira Buntenbroich, Ramona Schuster, Felix Babatz, Tânia Simões, Selver Altin, Gaetano Calabrese, Jan Riemer, Astrid Schauss, Mafalda Escobar-Henriques

    Vincent Anton ... Mafalda Escobar-Henriques

    Published 18 November 2019

    Mitochondrial fusion requires an alternating salt bridge between CMT2A-associated disease residues that enable GTP hydrolysis; Fzo1 ubiquitylation then licenses post-fusion recycling by Cdc48.

  • Nrf2 signaling links ER oxidative protein folding and calcium homeostasis in health and disease
    Open Access
    Nrf2 signaling links ER oxidative protein folding and calcium homeostasis in health and disease

    Veronica Granatiero, Csaba Konrad, Kirsten Bredvik, Giovanni Manfredi, Hibiki Kawamata

    Veronica Granatiero ... Hibiki Kawamata

    Published 28 October 2019

    Oxidative protein folding in the ER generates ROS, leading to Nrf2-dependent feedback on protein folding via ER calcium level modulation. This feedback loop is suppressed in ALS-associated mutant astrocytes but can be rescued by dimethyl fumarate.

  • Conservation of cell-intrinsic immune responses in diverse nonhuman primate species
    Open Access
    Conservation of cell-intrinsic immune responses in diverse nonhuman primate species

    Jenna M Gaska, Lance Parsons, Metodi Balev, Ann Cirincione, Wei Wang, Robert E Schwartz, Alexander Ploss

    Jenna M Gaska ... Alexander Ploss

    Published 24 October 2019

    The transcriptomic response of diverse nonhuman primate (NHP) species to poly(I:C) is highly conserved, and this novel RNA sequencing dataset will help improve NHP genome annotations.

  • Resolving kinesin stepping: one head at a time
    Open Access
    Resolving kinesin stepping: one head at a time

    Willi L Stepp, Zeynep Ökten

    Willi L Stepp ... Zeynep Ökten

    Published 10 October 2019

    This study shows for the first time a qualitative difference in the stepping of a heterodimeric motor and the asymmetric influence of autoinhibition on the stepping of one of the heads.

  • Chromatin remodeler Fft3 plays a dual role at blocked DNA replication forks
    Open Access
    Chromatin remodeler Fft3 plays a dual role at blocked DNA replication forks

    Anissia Ait-Saada, Olga Khorosjutina, Jiang Chen, Karol Kramarz, Vladimir Maksimov, J Peter Svensson, Sarah Lambert, Karl Ekwall

    Anissia Ait-Saada ... Karl Ekwall

    Published 1 October 2019

    Fft3, a member of the SNF2 family of ATPase-dependent enzymes, plays a dual role at DNA replication barriers in fission yeast by promoting both DNA resection and restart of blocked DNA replication forks.

  • HELZ directly interacts with CCR4–NOT and causes decay of bound mRNAs
    Open Access
    HELZ directly interacts with CCR4–NOT and causes decay of bound mRNAs

    Aoife Hanet, Felix Räsch, Ramona Weber, Vincenzo Ruscica, Maria Fauser, Tobias Raisch, Duygu Kuzuoğlu-Öztürk, Chung-Te Chang, Dipankar Bhandari, Cátia Igreja, Lara Wohlbold

    Aoife Hanet ... Lara Wohlbold

    Published 30 September 2019

    The putative UPF1-like SF1 helicase HELZ directly interacts with the CCR4–NOT deadenylase complex to induce translational repression and 5′-to-3′ decay of bound mRNAs.

  • Mechanistic insights into the protective roles of polyphosphate against amyloid cytotoxicity
    Open Access
    Mechanistic insights into the protective roles of polyphosphate against amyloid cytotoxicity

    Justine Lempart, Eric Tse, James A Lauer, Magdalena I Ivanova, Alexandra Sutter, Nicholas Yoo, Philipp Huettemann, Daniel Southworth, Ursula Jakob

    Justine Lempart ... Ursula Jakob

    Published 18 September 2019

    This study provides novel insights into the mechanisms by which presence of polyP alters the formation, structural properties, and cytotoxic effects of α-synuclein fibers.

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