Molecular Biology
- SRSF7 and SRSF3 depend on RNA sequencing motifs and secondary structures to regulate Microprocessor
Microprocessor cleaves pri-miRNAs to produce miRNAs. SRSF7 and SRSF3 interact with specific RNA elements in pri-miRNAs to modulate the cleavage of Microprocessor, thereby regulating miRNA biogenesis.
- The organizer of chromatin topology RIF1 ensures cellular resilience to DNA replication stress
The conserved protein RIF1 stabilizes replication factories and regulates cohesin recruitment in response to replication stress to limit DNA lesions.
- Plant mobile domain proteins ensure Microrchidia 1 expression to fulfill transposon silencing
The plant mobile domain proteins MAIN and MAIL1 control the expression of the epigenetic factor Microrchidia 1, which has been involved in transposable element silencing in Arabidopsis.
- Multi-level interaction between HIF and AHR transcriptional pathways in kidney carcinoma
This pan-genomic study of crosstalk between HIF and AHR transcription factors reveals both antagonistic and cooperative interactions and highlights their relevance to kidney cancer and its treatment.
- The ribose methylation enzyme FTSJ1 has a conserved role in neuron morphology and learning performance
This study adds insights into FTSJ1 tRNA 2′-O-methylation–associated pathologies in humans and Drosophila by identification of novel FTSJ1 targets and neuron morphology defects.
- The ADAM17 sheddase complex regulator iTAP/Frmd8 modulates inflammation and tumor growth
The FERM domain protein iTAP/Frmd8, which binds to and stabilizes the ADAM17/iRhom sheddase complex at the cell surface, is a regulator of inflammation, epithelial homeostasis, and tumor growth in vivo.
- The GET pathway serves to activate Atg32-mediated mitophagy by ER targeting of the Ppg1-Far complex
The GET pathway promotes anchoring of the Ppg1-Far phosphatase complex to the ER membrane, contributing to initiation of Atg32-mediated mitochondria-specific autophagy in budding yeast.
- Multiple phosphorylation of the Cdc48/p97 cofactor protein Shp1/p47 occurs upon cell stress in budding yeast
This study shows that phosphorylation of the yeast p97/Cdc48 adaptor protein Shp1 is enhanced upon multiple stresses, a process regulated by both Mpk1 kinase and PP1 phosphatase.
- S417 in the CC3 region of STIM1 is critical for STIM1-Orai1 binding and CRAC channel activation
This study shows that S417 of STIM1 plays an essential role in STIM1 C-terminus–Orai1 interaction and CRAC channel activation. It also presents new findings about 2-APB’s action on CRAC channel, which provides a tool for better understanding of SOCE activation.
- Structural and functional characterization of TraI from pKM101 reveals basis for DNA processing
Characterization of relaxase TraI from pKM101 highlights large conformational changes upon DNA binding, and unlike previous reports shows similar behavior as its homologs from the R388 and F plasmids.