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Molecular Biology

  • Rab1b and ARF5 are novel RNA-binding proteins involved in FMDV IRES–driven RNA localization
    Open Access
    Rab1b and ARF5 are novel RNA-binding proteins involved in FMDV IRES–driven RNA localization

    Javier Fernandez-Chamorro, Rosario Francisco-Velilla, Jorge Ramajo, Encarnación Martinez-Salas

    Javier Fernandez-Chamorro ... Encarnación Martinez-Salas

    Published 17 January 2019

    Integration of proteomic data with functional and imaging analysis revealed that Rab1b and ARF5, two ER-Golgi members, are RNA-binding proteins that colocalize with picornavirus IRES-RNA reporters in human cells.

  • Direct binding of Cdt2 to PCNA is important for targeting the CRL4<sup>Cdt2</sup> E3 ligase activity to Cdt1
    Open Access
    Direct binding of Cdt2 to PCNA is important for targeting the CRL4Cdt2 E3 ligase activity to Cdt1

    Akiyo Hayashi, Nickolaos Nikiforos Giakoumakis, Tatjana Heidebrecht, Takashi Ishii, Andreas Panagopoulos, Christophe Caillat, Michiyo Takahara, Richard G Hibbert, Naohiro Suenaga, Magda Stadnik-Spiewak, Tatsuro Takahashi, Yasushi Shiomi, Stavros Taraviras, Eleonore von Castelmur, Zoi Lygerou, Anastassis Perrakis, Hideo Nishitani

    Akiyo Hayashi ... Hideo Nishitani

    Published 31 December 2018

    The C-terminal end of Cdt2 contains a PIP box for binding to PCNA to promote CRL4Cdt2 function, creating a new paradigm where the substrate receptor and substrates bind to a common multivalent docking platform for ubiquitination.

  • Mouse REC114 is essential for meiotic DNA double-strand break formation and forms a complex with MEI4
    Open Access
    Mouse REC114 is essential for meiotic DNA double-strand break formation and forms a complex with MEI4

    Rajeev Kumar, Cecilia Oliver, Christine Brun, Ariadna B Juarez-Martinez, Yara Tarabay, Jan Kadlec, Bernard de Massy

    Rajeev Kumar ... Bernard de Massy

    Published 10 December 2018

    Mouse REC114 is essential for meiotic DNA double-strand break formation and forms a complex with IHO1. Its N-terminal region forms a Pleckstrin homology domain, while its C-terminal region is interacting with MEI4.

  • Dimerization and auto-processing induce caspase-11 protease activation within the non-canonical inflammasome
    Open Access
    Dimerization and auto-processing induce caspase-11 protease activation within the non-canonical inflammasome

    Connie Ross, Amy H Chan, Jessica Von Pein, Dave Boucher, Kate Schroder

    Connie Ross ... Kate Schroder

    Published 6 December 2018

    This study provides a detailed molecular mechanism for caspase-11 activation within the non-canonical inflammasome, giving new insight into host defence against cytosolic bacterial infection.

  • Topological in vitro loading of the budding yeast cohesin ring onto DNA
    Open Access
    Topological in vitro loading of the budding yeast cohesin ring onto DNA

    Masashi Minamino, Torahiko L Higashi, Céline Bouchoux, Frank Uhlmann

    Masashi Minamino ... Frank Uhlmann

    Published 26 October 2018

    The biochemical reconstitution of topological DNA binding by budding yeast cohesin yields surprises and opens opportunities to exploit experimental approaches developed in this model organism.

  • Specificity for deubiquitination of monoubiquitinated FANCD2 is driven by the N-terminus of USP1
    Open Access
    Specificity for deubiquitination of monoubiquitinated FANCD2 is driven by the N-terminus of USP1

    Connor Arkinson, Viduth K Chaugule, Rachel Toth, Helen Walden

    Connor Arkinson ... Helen Walden

    Published 12 October 2018

    Deubiquitination of FANCD2, FANCI, and PCNA by USP1 is essential for DNA repair signalling. Reconstitution of the system reveals that USP1-mediated specificity towards K561 of FANCD2 is directed by a unique sequence at USP1's N-terminus.

  • Ribosomal stalling landscapes revealed by high-throughput inverse toeprinting of mRNA libraries
    Open Access
    Ribosomal stalling landscapes revealed by high-throughput inverse toeprinting of mRNA libraries

    Britta Seip, Guénaël Sacheau, Denis Dupuy, C Axel Innis

    Britta Seip ... C Axel Innis

    Published 9 October 2018

    High-throughput inverse toeprinting identifies peptide-encoding transcripts that induce ribosome stalling and allows the systematic analysis of sequence-dependent translational events.

  • Interaction modulation through arrays of clustered methyl-arginine protein modifications
    Open Access
    Interaction modulation through arrays of clustered methyl-arginine protein modifications

    Jonathan Woodsmith, Victoria Casado-Medrano, Nouhad Benlasfer, Rebecca L Eccles, Saskia Hutten, Christian L Heine, Verena Thormann, Claudia Abou-Ajram, Oliver Rocks, Dorothee Dormann, Ulrich Stelzl

    Jonathan Woodsmith ... Ulrich Stelzl

    Published 21 September 2018

    Extensively modifiable arrays of clustered arginines in a large set of human proteins function as regulatory protein interaction platforms. Quantitative immunoprecipitation assays defined two distinct cumulative binding mechanisms operating across an array of 18 methyl-arginine motifs in SYNCRIP.

  • Transposon silencing in the <em>Drosophila</em> female germline is essential for genome stability in progeny embryos
    Open Access
    Transposon silencing in the Drosophila female germline is essential for genome stability in progeny embryos

    Zeljko Durdevic, Ramesh S Pillai, Anne Ephrussi

    Zeljko Durdevic ... Anne Ephrussi

    Published 17 September 2018

    Suppression of transposons by the Piwi-interacting RNA biogenesis factor Vasa in the supporting nurse cells is essential to prevent their accumulation in the developing oocyte, ensuring proper Drosophila embryonic development.

  • Laminin γ1 C-terminal Glu to Gln mutation induces early postimplantation lethality
    Open Access
    Laminin γ1 C-terminal Glu to Gln mutation induces early postimplantation lethality

    Daiji Kiyozumi, Yukimasa Taniguchi, Itsuko Nakano, Junko Toga, Emiko Yagi, Hidetoshi Hasuwa, Masahito Ikawa, Kiyotoshi Sekiguchi

    Daiji Kiyozumi ... Kiyotoshi Sekiguchi

    Published 10 September 2018

    Mouse embryos with an ablated ability of integrins to bind laminins are still able to form basement membranes, but die just after implantation because of deficient extraembryonic development.

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