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Molecular Biology

  • FIREWORKS: a bottom-up approach to integrative coessentiality network analysis
    Open Access
    FIREWORKS: a bottom-up approach to integrative coessentiality network analysis

    David R Amici, Jasen M Jackson, Mihai I Truica, Roger S Smith, Sarki A Abdulkadir, Marc L Mendillo

    David R Amici ... Marc L Mendillo

    Published 16 December 2020

    A tool to create bias-adjusted coessentiality networks reveals functional relationships between genes, context-specific rewiring of genetic networks, determinants of essentiality, and therapeutic targets for challenging proteins.

  • ESI mutagenesis: a one-step method for introducing mutations into bacterial artificial chromosomes
    Open Access
    ESI mutagenesis: a one-step method for introducing mutations into bacterial artificial chromosomes

    Arnaud Rondelet, Andrei Pozniakovsky, Devika Namboodiri, Richard Cardoso da Silva, Divya Singh, Marit Leuschner, Ina Poser, Andrea Ssykor, Julian Berlitz, Nadine Schmidt, Lea Röhder, Gerben Vader, Anthony A Hyman, Alexander W Bird

    Arnaud Rondelet ... Alexander W Bird

    Published 8 December 2020

    A simple and efficient recombineering-based method for introducing point mutations into bacterial artificial chromosomes using an artificial intron cassette.

  • Characterization of ori and parS-like functions in secondary genome replicons in <em>Deinococcus radiodurans</em>
    Open Access
    Characterization of ori and parS-like functions in secondary genome replicons in Deinococcus radiodurans

    Ganesh K Maurya, Hari S Misra

    Ganesh K Maurya ... Hari S Misra

    Published 16 November 2020

    An array of direct repeats upstream to parAB operon helps in secondary genome elements’ maintenance independent of primary chromosome in multipartite genome harboring bacterium Deinococcus radiodurans.

  • Inhibition of a transcriptional repressor rescues hearing in a splicing factor–deficient mouse
    Open Access
    Inhibition of a transcriptional repressor rescues hearing in a splicing factor–deficient mouse

    Yoko Nakano, Susan Wiechert, Bernd Fritzsch, Botond Bánfi

    Yoko Nakano ... Botond Bánfi

    Published 21 October 2020

    The vital role of the splicing factor SRRM4 in vestibular and inner hair cells of the ear is inactivation of the gene repressor REST; however, in outer hair cells, SRRM4 is dispensable for REST inactivation, which SRRM3 accomplishes independently.

  • Mps2 links Csm4 and Mps3 to form a telomere-associated LINC complex in budding yeast
    Open Access
    Mps2 links Csm4 and Mps3 to form a telomere-associated LINC complex in budding yeast

    Jinbo Fan, Hui Jin, Bailey A Koch, Hong-Guo Yu

    Jinbo Fan ... Hong-Guo Yu

    Published 23 September 2020

    The canonical LINC complex is composed of two different transmembrane proteins; this work reveals the heterotrimeric composition of the telomere-associated LINC complex in budding yeast.

  • Biochemical and functional characterization of a meiosis-specific Pch2/ORC AAA+ assembly
    Open Access
    Biochemical and functional characterization of a meiosis-specific Pch2/ORC AAA+ assembly

    María Ascensión Villar-Fernández, Richard Cardoso da Silva, Magdalena Firlej, Dongqing Pan, Elisabeth Weir, Annika Sarembe, Vivek B Raina, Tanja Bange, John R Weir, Gerben Vader

    María Ascensión Villar-Fernández ... Gerben Vader

    Published 21 August 2020

    The AAA+ protein Pch2 forms a biochemical complex with Orc1/ORC to suppress DNA break formation in the meiotic G2/prophase.

  • The RECQL helicase prevents replication fork collapse during replication stress
    Open Access
    The RECQL helicase prevents replication fork collapse during replication stress

    Bente Benedict, Marit AE van Bueren, Frank PA van Gemert, Cor Lieftink, Sergi Guerrero Llobet, Marcel ATM van Vugt, Roderick L Beijersbergen, Hein te Riele

    Bente Benedict ... Hein te Riele

    Published 20 August 2020

    This work shows that RECQL is an essential player in the protection of stalled replication forks and possibly the restart of broken replication forks, thereby representing a target for cancer therapy.

  • DDX5 promotes oncogene C3 and FABP1 expressions and drives intestinal inflammation and tumorigenesis
    Open Access
    DDX5 promotes oncogene C3 and FABP1 expressions and drives intestinal inflammation and tumorigenesis

    Nazia Abbasi, Tianyun Long, Yuxin Li, Brian A Yee, Benjamin S Cho, Juan E Hernandez, Evelyn Ma, Parth R Patel, Debashis Sahoo, Ibrahim M Sayed, Nissi Varki, Soumita Das, Pradipta Ghosh, Gene W Yeo, Wendy Jia Men Huang

    Nazia Abbasi ... Wendy Jia Men Huang

    Published 18 August 2020

    In intestinal epithelial cells (IECs), DDX5 promotes the expression of immune response genes and oncogenes posttranscriptionally and is a novel therapeutic target for treating colitis and intestinal cancers.

  • Evolutionary divergence reveals the molecular basis of EMRE dependence of the human MCU
    Open Access
    Evolutionary divergence reveals the molecular basis of EMRE dependence of the human MCU

    Melissa JS MacEwen, Andrew L Markhard, Mert Bozbeyoglu, Forrest Bradford, Olga Goldberger, Vamsi K Mootha, Yasemin Sancak

    Melissa JS MacEwen ... Yasemin Sancak

    Published 7 August 2020

    Using clues from evolution, chimeric proteins, and biochemical methods, this work identifies a new domain in mitochondrial calcium uniporter that determines its dependence on its binding partner EMRE.

  • A paralog-specific role of COPI vesicles in the neuronal differentiation of mouse pluripotent cells
    Open Access
    A paralog-specific role of COPI vesicles in the neuronal differentiation of mouse pluripotent cells

    Manu Jain Goyal, Xiyan Zhao, Mariya Bozhinova, Karla Andrade-López, Cecilia de Heus, Sandra Schulze-Dramac, Michaela Müller-McNicoll, Judith Klumperman, Julien Béthune

    Manu Jain Goyal ... Julien Béthune

    Published 14 July 2020

    The paralogous COPI coat subunit γ1-COP plays a unique role in promoting neurite outgrowth during the neuronal differentiation of mouse pluripotent cells.

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