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Molecular Biology

  • Loss of PGC-1α in RPE induces mesenchymal transition and promotes retinal degeneration
    Open Access
    Loss of PGC-1α in RPE induces mesenchymal transition and promotes retinal degeneration

    Mariana Aparecida Brunini Rosales, Daisy Y Shu, Jared Iacovelli, Magali Saint-Geniez

    Mariana Aparecida Brunini Rosales ... Magali Saint-Geniez

    Published 17 May 2019

    Sustained loss of PGC-1α in RPE cells triggers mitochondrial/autophagic dysfunction and oxidative damage resulting in epithelial dedifferentiation and mesenchymal transition. RPE dysfunction caused by deletion of the PGC-1 coactivators in vivo causes retinal degeneration.

  • An N-terminal–truncated isoform of FAM134B (FAM134B-2) regulates starvation-induced hepatic selective ER-phagy
    Open Access
    An N-terminal–truncated isoform of FAM134B (FAM134B-2) regulates starvation-induced hepatic selective ER-phagy

    Shohei Kohno, Yuji Shiozaki, Audrey L Keenan, Shinobu Miyazaki-Anzai, Makoto Miyazaki

    Shohei Kohno ... Makoto Miyazaki

    Published 17 May 2019

    This study has identified a novel truncated isoform of FAM134B (FAM134B-2) that regulates starvation-induced selective ER-phagy of secretory proteins such as ApoCIII through the activation of C/EBPβ.

  • Cellular response upon proliferation in the presence of an active mitotic checkpoint
    Open Access
    Cellular response upon proliferation in the presence of an active mitotic checkpoint

    Andrea Corno, Elena Chiroli, Fridolin Gross, Claudio Vernieri, Vittoria Matafora, Stefano Maffini, Marco Cosentino Lagomarsino, Angela Bachi, Andrea Ciliberto

    Andrea Corno ... Andrea Ciliberto

    Published 8 May 2019

    Cells that replicate with an active mitotic checkpoint remain capable to mount multiple times an efficient arrest, are bigger than unperturbed cells, rely more heavily on Cdh1, and have an altered protein expression profile.

  • Characterisation of class VI TRIM RING domains: linking RING activity to C-terminal domain identity
    Open Access
    Characterisation of class VI TRIM RING domains: linking RING activity to C-terminal domain identity

    Rebecca V Stevens, Diego Esposito, Katrin Rittinger

    Rebecca V Stevens ... Katrin Rittinger

    Published 26 April 2019

    This study shows that members of the class VI TRIM E3 ligase family contain monomeric RING domains and display no ligase activity and may require additional regulatory events to promote ubiquitination.

  • Noncoding AUG circRNAs constitute an abundant and conserved subclass of circles
    Open Access
    Noncoding AUG circRNAs constitute an abundant and conserved subclass of circles

    Lotte VW Stagsted, Katrine M Nielsen, Iben Daugaard, Thomas B Hansen

    Lotte VW Stagsted ... Thomas B Hansen

    Published 26 April 2019

    AUG circRNAs are highly abundant and conserved with an Alu-independent mode of biogenesis. Although AUG circRNAs contain the N-terminal ORFs, no evidence supports translation of these circRNAs.

  • The impact of poly-A microsatellite heterologies in meiotic recombination
    Open Access
    The impact of poly-A microsatellite heterologies in meiotic recombination

    Angelika Heissl, Andrea J Betancourt, Philipp Hermann, Gundula Povysil, Barbara Arbeithuber, Andreas Futschik, Thomas Ebner, Irene Tiemann-Boege

    Angelika Heissl ... Irene Tiemann-Boege

    Published 25 April 2019

    Meiosis strongly influences the transmission and evolution of heterozygous poly-A repeats as measured experimentally in a large collection of single recombination products in a human hotspot.

  • CXXC5 mediates growth plate senescence and is a target for enhancement of longitudinal bone growth
    Open Access
    CXXC5 mediates growth plate senescence and is a target for enhancement of longitudinal bone growth

    Sehee Choi, Hyun-Yi Kim, Pu-Hyeon Cha, Seol Hwa Seo, Chulho Lee, Yejoo Choi, Wookjin Shin, Yunseok Heo, Gyoonhee Han, Weontae Lee, Kang-Yell Choi

    Sehee Choi ... Kang-Yell Choi

    Published 10 April 2019

    Inhibition of the CXXC5–DVL interaction is a potential therapeutic strategy for height enhancement of children with growth retardation.

  • m<sup>6</sup>A-mRNA methylation regulates cardiac gene expression and cellular growth
    Open Access
    m6A-mRNA methylation regulates cardiac gene expression and cellular growth

    Vivien Kmietczyk, Eva Riechert, Laura Kalinski, Etienne Boileau, Ellen Malovrh, Brandon Malone, Agnieszka Gorska, Christoph Hofmann, Eshita Varma, Lonny Jürgensen, Verena Kamuf-Schenk, Janine Altmüller, Rewati Tappu, Martin Busch, Patrick Most, Hugo A Katus, Christoph Dieterich, Mirko Völkers

    Vivien Kmietczyk ... Mirko Völkers

    Published 9 April 2019

    This study provides evidence that m6A methylation is dynamically regulated during human and murine cardiac disease and highlights an important role of the m6A methylase Mettl3 in regulating cardiac growth by gene expression control.

  • Sequence and expression levels of circular RNAs in progenitor cell types during mouse corticogenesis
    Open Access
    Sequence and expression levels of circular RNAs in progenitor cell types during mouse corticogenesis

    Martina Dori, Leila Haj Abdullah Alieh, Daniel Cavalli, Simone Massalini, Mathias Lesche, Andreas Dahl, Federico Calegari

    Martina Dori ... Federico Calegari

    Published 29 March 2019

    This study identifies circular RNAs (circRNAs) in specific cell types of the developing mammalian cortex. This resource addresses the complexity and potential significance of this elusive class of transcripts.

  • A dual role for SAMHD1 in regulating HBV cccDNA and RT-dependent particle genesis
    Open Access
    A dual role for SAMHD1 in regulating HBV cccDNA and RT-dependent particle genesis

    Peter AC Wing, Tamara Davenne, Jochen Wettengel, Alvina G Lai, Xiaodong Zhuang, Anindita Chakraborty, Valentina D’Arienzo, Catharina Kramer, Chunkyu Ko, James M Harris, Sabrina Schreiner, Martin Higgs, Stephanie Roessler, Joanna L Parish, Ulrike Protzer, Peter Balfe, Jan Rehwinkel, Jane A McKeating

    Peter AC Wing ... Jane A McKeating

    Published 27 March 2019

    Our study highlights a dual role for SAMHD1 in regulating hepatitis B virus cccDNA levels and reverse transcriptase–dependent particle genesis.

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