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Molecular Biology

  • The AXL-PYK2-PKCα axis as a nexus of stemness circuits in TNBC
    Open Access
    The AXL-PYK2-PKCα axis as a nexus of stemness circuits in TNBC

    Lohit Khera, Yaron Vinik, Flavio Maina, Sima Lev

    Lohit Khera ... Sima Lev

    Published 30 March 2021

    A clinically relevant AXL-PYK2-PKCα axis where PYK2 and PKCα act as signaling nodes and functionally cooperate to converge stemness promoting pathways and regulate Oct4 and Nanog pluripotent TFs.

  • Mapping the micro-proteome of the nuclear lamina and lamina-associated domains
    Open Access
    Mapping the micro-proteome of the nuclear lamina and lamina-associated domains

    Xianrong Wong, Jevon A Cutler, Victoria E Hoskins, Molly Gordon, Anil K Madugundu, Akhilesh Pandey, Karen L Reddy

    Xianrong Wong ... Karen L Reddy

    Published 23 March 2021

    The nuclear lamina provides structure to the nucleus and serves as an interface between the cytoskeleton and large heterochromatin domains called LADs. This study describes the microproteome of this LAD/lamina interface.

  • Arterial stiffness and cardiac dysfunction in Hutchinson–Gilford Progeria Syndrome corrected by inhibition of lysyl oxidase
    Open Access
    Arterial stiffness and cardiac dysfunction in Hutchinson–Gilford Progeria Syndrome corrected by inhibition of lysyl oxidase

    Ryan von Kleeck, Emilia Roberts, Paola Castagnino, Kyle Bruun, Sonja A Brankovic, Elizabeth A Hawthorne, Tina Xu, John W Tobias, Richard K Assoian

    Ryan von Kleeck ... Richard K Assoian

    Published 9 March 2021

    The findings show that increased lysyl oxidase abundance is causal for the elevated arterial stiffness present in the arteries of Hutchinson–Gilford Progeria Syndrome mice. Pharmacologic inhibition of lysyl oxidase improves cardiac dysfunction and restores arterial compliance.

  • Concomitant gain and loss of function pathomechanisms in C9ORF72 amyotrophic lateral sclerosis
    Open Access
    Concomitant gain and loss of function pathomechanisms in C9ORF72 amyotrophic lateral sclerosis

    Arun Pal, Benedikt Kretner, Masin Abo-Rady, Hannes Glaβ, Banaja P Dash, Marcel Naumann, Julia Japtok, Nicole Kreiter, Ashutosh Dhingra, Peter Heutink, Tobias M Böckers, René Günther, Jared Sterneckert, Andreas Hermann

    Arun Pal ... Andreas Hermann

    Published 22 February 2021

    Axonal trafficking deficits and neurodegeneration in C9ORF72 motoneurons are mediated by GOF and LOF mechanisms with RNA foci and DPRs as upstream events, whereas DNA damage appears downstream.

  • Modulating HSF1 levels impacts expression of the estrogen receptor α and antiestrogen response
    Open Access
    Modulating HSF1 levels impacts expression of the estrogen receptor α and antiestrogen response

    Maruhen AD Silveira, Christophe Tav, Félix-Antoine Bérube-Simard, Tania Cuppens, Mickaël Leclercq, Éric Fournier, Maxime C Côté, Arnaud Droit, Steve Bilodeau

    Maruhen AD Silveira ... Steve Bilodeau

    Published 16 February 2021

    This work shows that activation of the main cellular stress response pathway is responsible for antiestrogen resistance in breast cancer, a process that is reversible.

  • CDCP1 promotes compensatory renal growth by integrating Src and Met signaling
    Open Access
    CDCP1 promotes compensatory renal growth by integrating Src and Met signaling

    Kentaro Kajiwara, Shotaro Yamano, Kazuhiro Aoki, Daisuke Okuzaki, Kunio Matsumoto, Masato Okada

    Kentaro Kajiwara ... Masato Okada

    Published 11 February 2021

    CDCP1 promotes HGF-induced compensatory renal growth by focally and temporally integrating Src and Met-STAT3 signaling in lipid rafts.

  • Structural comparison of GLUT1 to GLUT3 reveal transport regulation mechanism in sugar porter family
    Open Access
    Structural comparison of GLUT1 to GLUT3 reveal transport regulation mechanism in sugar porter family

    Tânia Filipa Custódio, Peter Aasted Paulsen, Kelly May Frain, Bjørn Panyella Pedersen

    Tânia Filipa Custódio ... Bjørn Panyella Pedersen

    Published 3 February 2021

    A new structure of GLUT1, compared with GLUT3, can explain substrate affinity differences, and provide a functional rationale for key structural motifs that define the universal Sugar Porter family.

  • Reduced RNA turnover as a driver of cellular senescence
    Open Access
    Reduced RNA turnover as a driver of cellular senescence

    Nowsheen Mullani, Yevheniia Porozhan, Adèle Mangelinck, Christophe Rachez, Mickael Costallat, Eric Batsché, Michele Goodhardt, Giovanni Cenci, Carl Mann, Christian Muchardt

    Nowsheen Mullani ... Christian Muchardt

    Published 14 January 2021

    RNAs originating from transcription upstream and downstream of genes accumulate in the cytoplasm of a subset of senescent cells, suggesting an RNA alternative to cytoplasmic DNA in the triggering of senescence.

  • The uncharacterized protein FAM47E interacts with PRMT5 and regulates its functions
    Open Access
    The uncharacterized protein FAM47E interacts with PRMT5 and regulates its functions

    Baskar Chakrapani, Mohd Imran K Khan, Rajashekar Varma Kadumuri, Somlee Gupta, Mamta Verma, Sharad Awasthi, Gayathri Govindaraju, Arun Mahesh, Arumugam Rajavelu, Sreenivas Chavali, Arunkumar Dhayalan

    Baskar Chakrapani ... Arunkumar Dhayalan

    Published 29 December 2020

    The uncharacterized protein FAM47E interacts with and stabilizes the protein arginine methyltransferase PRMT5, regulating its epigenetic functions thereby modulating target gene expression.

  • HTR6 and SSTR3 ciliary targeting relies on both IC3 loops and C-terminal tails
    Open Access
    HTR6 and SSTR3 ciliary targeting relies on both IC3 loops and C-terminal tails

    Pablo Barbeito, Yuki Tachibana, Raquel Martin-Morales, Paula Moreno, Kirk Mykytyn, Tetsuo Kobayashi, Francesc R Garcia-Gonzalo

    Pablo Barbeito ... Francesc R Garcia-Gonzalo

    Published 28 December 2020

    Ciliary accumulation of G protein–coupled receptors HTR6 and SSTR3 depends on redundant ciliary targeting sequences acting via ciliary trafficking adapters TULP3 and RABL2.

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