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Molecular Biology

  • CRISPR-induced double-strand breaks trigger recombination between homologous chromosome arms
    Open Access
    CRISPR-induced double-strand breaks trigger recombination between homologous chromosome arms

    Erich Brunner, Ryohei Yagi, Marc Debrunner, Dezirae Beck-Schneider, Alexa Burger, Eliane Escher, Christian Mosimann, George Hausmann, Konrad Basler

    Erich Brunner ... Konrad Basler

    Published 13 June 2019

    CRISPR–Cas9 enables recombination between homologous chromosome arms at predefined sites and also underscores the need for caution when applying CRISPR technologies in translational medicine.

  • Molecular characterization of <em>Chlamydomonas reinhardtii</em> telomeres and telomerase mutants
    Open Access
    Molecular characterization of Chlamydomonas reinhardtii telomeres and telomerase mutants

    Stephan Eberhard, Sona Valuchova, Julie Ravat, Jaroslav Fulneček, Pascale Jolivet, Sandrine Bujaldon, Stéphane D Lemaire, Francis-André Wollman, Maria Teresa Teixeira, Karel Riha, Zhou Xu

    Stephan Eberhard ... Zhou Xu

    Published 3 June 2019

    This study characterizes the sequence, end structure, and length distribution of Chlamydomonas reinhardtii telomeres and shows that telomerase mutants are defective in telomere maintenance.

  • ATP hydrolysis by KaiC promotes its KaiA binding in the cyanobacterial circadian clock system
    Open Access
    ATP hydrolysis by KaiC promotes its KaiA binding in the cyanobacterial circadian clock system

    Yasuhiro Yunoki, Kentaro Ishii, Maho Yagi-Utsumi, Reiko Murakami, Susumu Uchiyama, Hirokazu Yagi, Koichi Kato

    Yasuhiro Yunoki ... Koichi Kato

    Published 3 June 2019

    ATP hydrolysis in the KaiC hexamer triggers the exposure of its C-terminal segments into the solvent so as to capture KaiA, providing mechanistic insights into the circadian periodicity regulation.

  • Robust repression of tRNA gene transcription during stress requires protein arginine methylation
    Open Access
    Robust repression of tRNA gene transcription during stress requires protein arginine methylation

    Richoo B Davis, Neah Likhite, Christopher A Jackson, Tao Liu, Michael C Yu

    Richoo B Davis ... Michael C Yu

    Published 3 June 2019

    This work examines how protein arginine methylation of Rpc31, a subunit of RNA Pol III, promotes negative regulation of tRNA biogenesis in the context of cellular stress.

  • Open Access
    Correction: Loss of PGC-1α in RPE induces mesenchymal transition and promotes retinal degeneration

    Mariana Aparecida Brunini Rosales, Daisy Y Shu, Jared Iacovelli, Magali Saint-Geniez

    Mariana Aparecida Brunini Rosales ... Magali Saint-Geniez

    Published 29 May 2019
  • PKAc is not required for the preerythrocytic stages of <em>Plasmodium berghei</em>
    Open Access
    PKAc is not required for the preerythrocytic stages of Plasmodium berghei

    Hadi Hasan Choudhary, Roshni Gupta, Satish Mishra

    Hadi Hasan Choudhary ... Satish Mishra

    Published 29 May 2019

    The mutant salivary gland sporozoites lacking PKAc are able to glide, invade hepatocytes, and mature into hepatic merozoites, which release successfully from the merosome, however, fail to initiate blood stage infection when inoculated into mice.

  • The m<sup>6</sup>A pathway protects the transcriptome integrity by restricting RNA chimera formation in plants
    Open Access
    The m6A pathway protects the transcriptome integrity by restricting RNA chimera formation in plants

    Dominique Pontier, Claire Picart, Moaine El Baidouri, François Roudier, Tao Xu, Sylvie Lahmy, Christel Llauro, Jacinthe Azevedo, Michèle Laudié, Aurore Attina, Christophe Hirtz, Marie-Christine Carpentier, Lisha Shen, Thierry Lagrange

    Dominique Pontier ... Thierry Lagrange

    Published 29 May 2019

    This study reveals that an m6A-assisted polyadenylation pathway comprising conserved m6A writer proteins and a plant-specific m6A reader contributes to transcriptome integrity in Arabidopsis thaliana by restricting RNA chimera formation at rearranged loci.

  • Tumor-intrinsic response to IFNγ shapes the tumor microenvironment and anti–PD-1 response in NSCLC
    Open Access
    Tumor-intrinsic response to IFNγ shapes the tumor microenvironment and anti–PD-1 response in NSCLC

    Bonnie L Bullock, Abigail K Kimball, Joanna M Poczobutt, Alexander J Neuwelt, Howard Y Li, Amber M Johnson, Jeff W Kwak, Emily K Kleczko, Rachael E Kaspar, Emily K Wagner, Katharina Hopp, Erin L Schenk, Mary CM Weiser-Evans, Eric T Clambey, Raphael A Nemenoff

    Bonnie L Bullock ... Raphael A Nemenoff

    Published 27 May 2019

    Using an immunocompetent mouse model of NSCLC, this study demonstrates that tumor-intrinsic response to IFNγ determines response to anti–PD-1 through alterations in the tumor microenvironment.

  • The hypoxia-response pathway modulates RAS/MAPK–mediated cell fate decisions in <em>Caenorhabditis elegans</em>
    Open Access
    The hypoxia-response pathway modulates RAS/MAPK–mediated cell fate decisions in Caenorhabditis elegans

    Sabrina Maxeiner, Judith Grolleman, Tobias Schmid, Jan Kammenga, Alex Hajnal

    Sabrina Maxeiner ... Alex Hajnal

    Published 24 May 2019

    Atmospheric oxygen levels modulate the RAS/MAPK signaling pathway in the nematode Caenorhabditis elegans through a cross-talk between the DELTA/NOTCH and hypoxia signaling pathways. These mechanisms may permit the animals to adapt their development to changes in the environment.

  • Loss of PGC-1α in RPE induces mesenchymal transition and promotes retinal degeneration
    Open Access
    Loss of PGC-1α in RPE induces mesenchymal transition and promotes retinal degeneration

    Mariana Aparecida Brunini Rosales, Daisy Y Shu, Jared Iacovelli, Magali Saint-Geniez

    Mariana Aparecida Brunini Rosales ... Magali Saint-Geniez

    Published 17 May 2019

    Sustained loss of PGC-1α in RPE cells triggers mitochondrial/autophagic dysfunction and oxidative damage resulting in epithelial dedifferentiation and mesenchymal transition. RPE dysfunction caused by deletion of the PGC-1 coactivators in vivo causes retinal degeneration.

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