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Molecular Biology

  • Evolutionary association of receptor-wide amino acids with G protein–coupling selectivity in aminergic GPCRs
    Open Access
    Evolutionary association of receptor-wide amino acids with G protein–coupling selectivity in aminergic GPCRs

    Berkay Selçuk, Ismail Erol, Serdar Durdağı, Ogün Adebali

    Berkay Selçuk ... Ogün Adebali

    Published 25 May 2022

    Evolutionary analyses of aminergic G protein–coupled receptors reveal receptor-wide potential determinants of G protein–coupling selectivity.

  • DUSP4 protects BRAF- and NRAS-mutant melanoma from oncogene overdose through modulation of MITF
    Open Access
    DUSP4 protects BRAF- and NRAS-mutant melanoma from oncogene overdose through modulation of MITF

    Nuria Gutierrez-Prat, Hedwig L Zuberer, Luca Mangano, Zahra Karimaddini, Luise Wolf, Stefka Tyanova, Lisa C Wellinger, Daniel Marbach, Vera Griesser, Piergiorgio Pettazzoni, James R Bischoff, Daniel Rohle, Chiara Palladino, Igor Vivanco

    Nuria Gutierrez-Prat ... Igor Vivanco

    Published 17 May 2022

    Our study demonstrates that in BRAF- and NRAS-mutant MITF-proficient melanoma, the DUSP4 MAPK phosphatase restricts MAPK activation and prevents oncogenic overdose through modulation of MITF function.

  • <em>C9ORF72</em>-derived poly-GA DPRs undergo endocytic uptake in iAstrocytes and spread to motor neurons
    Open Access
    C9ORF72-derived poly-GA DPRs undergo endocytic uptake in iAstrocytes and spread to motor neurons

    Paolo M Marchi, Lara Marrone, Laurent Brasseur, Audrey Coens, Christopher P Webster, Luc Bousset, Marco Destro, Emma F Smith, Christa G Walther, Victor Alfred, Raffaele Marroccella, Emily J Graves, Darren Robinson, Allan C Shaw, Lai Mei Wan, Andrew J Grierson, Stephen J Ebbens, Kurt J De Vos, Guillaume M Hautbergue, Laura Ferraiuolo, Ronald Melki, Mimoun Azzouz

    Paolo M Marchi ... Mimoun Azzouz

    Published 13 May 2022

    Extracellularly delivered poly-GAs are internalised into astrocytes via an endocytosis-dependent pathway and then spread to motor neurons, implying non-cell autonomous mechanisms in C9ORF72-ALS/FTD.

  • Molecular insights into RNA recognition and gene regulation by the TRIM-NHL protein Mei-P26
    Open Access
    Molecular insights into RNA recognition and gene regulation by the TRIM-NHL protein Mei-P26

    Anna Salerno-Kochan, Andreas Horn, Pritha Ghosh, Chandran Nithin, Anna Kościelniak, Andreas Meindl, Daniela Strauss, Rościsław Krutyhołowa, Oliver Rossbach, Janusz M Bujnicki, Monika Gaik, Jan Medenbach, Sebastian Glatt

    Anna Salerno-Kochan ... Sebastian Glatt

    Published 5 May 2022

    This study provides molecular insights into RNA target recognition by the TRIM-NHL protein Mei-P26 that functions in Drosophila ovarian germline stem cell maintenance, oogenesis, and spermatogenesis.

  • Rab40c regulates focal adhesions and PP6 activity by controlling ANKRD28 ubiquitylation
    Open Access
    Rab40c regulates focal adhesions and PP6 activity by controlling ANKRD28 ubiquitylation

    Ke-Jun Han, Valeryia Mikalayeva, Scott A Gerber, Arminja N Kettenbach, Vytenis A Skeberdis, Rytis Prekeris

    Ke-Jun Han ... Rytis Prekeris

    Published 5 May 2022

    The role of novel Rab40c/CRL5 ubiquitylation complex in regulating PP6 activity and cell migration.

  • The miR-26 family regulates early B cell development and transformation
    Open Access
    The miR-26 family regulates early B cell development and transformation

    Katharina Hutter, Silke E Lindner, Constanze Kurschat, Thomas Rülicke, Andreas Villunger, Sebastian Herzog

    Katharina Hutter ... Sebastian Herzog

    Published 22 April 2022

    We show that the activity of the miR-26 family determines early B cell behavior: high miR-26 levels promote cell expansion and block the pre-B to immature B cell transition, whereas a miR-26 reduction limits expansion and enhances pre-B cell differentiation.

  • Phospholipids alter activity and stability of mitochondrial membrane-bound ubiquitin ligase MARCH5
    Open Access
    Phospholipids alter activity and stability of mitochondrial membrane-bound ubiquitin ligase MARCH5

    Lisa Merklinger, Johannes Bauer, Per A Pedersen, Rune Busk Damgaard, J Preben Morth

    Lisa Merklinger ... J Preben Morth

    Published 22 April 2022

    This study shows that lipids can act as regulators for the ubiquitination process and can control the stability and activity of a membrane-embedded E3 ubiquitin ligase.

  • Tricalbin proteins regulate plasma membrane phospholipid homeostasis
    Open Access
    Tricalbin proteins regulate plasma membrane phospholipid homeostasis

    Ffion B Thomas, Deike J Omnus, Jakob M Bader, Gary HC Chung, Nozomu Kono, Christopher J Stefan

    Ffion B Thomas ... Christopher J Stefan

    Published 19 April 2022

    The extended synaptotagmin (E-Syt) family are conserved proteins that function at membrane contacts. This study reveals that yeast E-Syt family members regulate phospholipid homeostasis necessary for plasma membrane integrity.

  • LuminoCell: a versatile and affordable platform for real-time monitoring of luciferase-based reporters
    Open Access
    LuminoCell: a versatile and affordable platform for real-time monitoring of luciferase-based reporters

    Kamila Weissová, Bohumil Fafílek, Tomasz Radaszkiewicz, Canan Celiker, Petra Macháčková, Tamara Čechová, Jana Šebestíková, Aleš Hampl, Vítězslav Bryja, Pavel Krejčí, Tomáš Bárta

    Kamila Weissová ... Tomáš Bárta

    Published 19 April 2022

    Description of affordable ($40) open-source platform for real-time in-cell monitoring of luciferase activity.

  • Functional and structural deficiencies of Gemin5 variants associated with neurological disorders
    Open Access
    Functional and structural deficiencies of Gemin5 variants associated with neurological disorders

    Rosario Francisco-Velilla, Azman Embarc-Buh, Francisco del Caño-Ochoa, Salvador Abellan, Marçal Vilar, Sara Alvarez, Alberto Fernandez-Jaen, Sukhleen Kour, Deepa S Rajan, Udai Bhan Pandey, Santiago Ramón-Maiques, Encarnacion Martinez-Salas

    Rosario Francisco-Velilla ... Encarnacion Martinez-Salas

    Published 7 April 2022

    Gemin5 clinical variants perturbing the dimerization module and the noncanonical RNA-binding site impair oligomerization, RNA–protein interaction networks, ribosome association, and protein stability.

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