Microbiology, Virology & Host Pathogen Interaction
Genome analysis of Legionella pneumophila ST23 from various countries reveals highly similar strainsST23 isolated in Italy are analysed by cgMLST and SNP approaches and they are also compared with ST23 from other countries. They are found to be phylogenetically related independently on year, town, or country of isolation.
Leishmania survives by exporting miR-146a from infected to resident cells to subjugate inflammationLeishmania donovani infects and hijacks microRNA import-export machinery of host macrophages and survives by communicating the host-derived miR-146a to neighbouring cells and stops inflammation.
Human immunodeficiency virus type 1 impairs sumoylationThe HIV type 1 dampens host cell sumoylation in vitro and reduces the expression of UBA2 protein, a subunit of the SUMO E1–activating enzyme. In vivo, infection in patients is associated with diminished global leukocyte sumoylation activity.
Proteomic landscape of SARS-CoV-2– and MERS-CoV–infected primary human renal epithelial cellsTranslatome and proteome analyses of human proximal and distal tubular cells during coronavirus infection reveal distinctive host cell response patterns important for viral replication and renal pathology.
Topical TMPRSS2 inhibition prevents SARS-CoV-2 infection in differentiated human airway culturesThere is an urgent need to develop novel therapeutic strategies to prevent viral transmission and COVID-19 disease—we show that topical application of camostat, a TMPRSS2 inhibitor, could be a simple, safe, and effective strategy for restricting upper airway infection.
Malaria abrogates O’nyong–nyong virus pathologies by restricting virus infection in nonimmune cellsThis study reveals that acute blood-stage malaria promotes resistance to ONNV infection by inducing IFNg-dependent antiviral status in human and murine nonimmune cells.
Age-related differences in immune dynamics during SARS-CoV-2 infection in rhesus macaquesIncreased age is a risk factor for severe COVID-19. Multi-omics profiling in rhesus macaques suggests that aging may delay or impair cellular immune responses and the return to immune homeostasis.
Preclinical and randomized phase I studies of plitidepsin in adults hospitalized with COVID-19This proof-of-concept study shows that plitidepsin, a marine peptide that inhibits SARS-CoV-2 replication, has a favorable safety profile and may be an efficacious treatment for patients with COVID-19.
Sensitive visualization of SARS-CoV-2 RNA with CoronaFISHWe design an RNA-FISH method to target the plus and minus strands of SARS-CoV-2 RNA, and apply it to image the virus in cell lines, lung tissue, and nasal swabs, by fluorescence and electron microscopy.
Artemisinin-independent inhibitory activity of Artemisia sp. infusions against different Plasmodium stages including relapse-causing hypnozoitesInfusions from two Artemisia species, one containing artemisinin, the other not, equally inhibit pre-erythrocytic and erythrocytic stages of different Plasmodium species, including two relapsing species.