Microbiology, Virology & Host Pathogen Interaction
FBXO11 governs macrophage cell death and inflammation in response to bacterial toxinsFBXO11 regulates the expression of the complement receptor C5aR1 and the inflammatory cytokine IL-1β, affecting how macrophages respond to Staphylococcus aureus pore–forming toxins.
Reduced replication but increased interferon resistance of SARS-CoV-2 Omicron BA.1The SARS-CoV-2 Omicron BA.1 variant of concern is highly resistant against exogenous interferons, suggesting that effective innate immune evasion contributed to its success.
Characterisation of the OTU domain deubiquitinase complement of Toxoplasma gondiiThe OTU deubiquitinase family is expanded in Toxoplasma parasites, and members show preferences for Lys6-, Lys11-, Lys48-, and Lys63-linked ubiquitin chains, and additional specificity for NEDD8. AlphaFold-guided structural analysis reveals cryptic ubiquitin-binding domains with functional importance.
Potency assessment of IFNγ-producing SARS-CoV-2-specific T cells from COVID-19 convalescent subjectsSARS-CoV-2-specific T-cells from convalescent donors present phenotypical and functional characteristics that make them a suitable candidate for a future development of an advanced cellular therapy.
Genomic insights into antibiotic resistance and mobilome of lactic acid bacteria and bifidobacteriaWhole-genome sequencing is used to discover novel potential mechanisms of antimicrobial resistance and mobile genetic elements in lactic acid bacteria and bifidobacteria from the agro-food chain.
Tannins amount determines whether tannase-containing bacteria are probiotic or pathogenic in IBDTA-induced microbial metabolite GA displays dual effects on IBD. GA exerts its function through two ways: influence bacteria penetration and directly affect epithelial cells. Interaction between diet and microbial enzyme is pivotal in affecting IBD.
Tyrosine phosphorylation controlled poly(A) polymerase I activity regulates general stress response in bacteriaWe show a tyrosine phosphorylation–controlled poly(A) polymerase I polyadenylation activity regulated stress response mechanism in bacteria that is distinct and operates downstream of the primary stress regulator RpoS.
Horizontal transfer of the rfb cluster in Leptospira is a genetic determinant of serovar identityLeptospira strains show very large antigenic variation (serovars). Here, the rfb gene cluster is shown to be transferred horizontally within/among Leptospira species, discriminating serovar identity.
Pandemic Vibrio cholerae acquired competitive traits from an environmental Vibrio speciesPandemic-associated Vibrio cholerae interbacterial defense genes were likely acquired through competition with and subsequent gene transfer from the fish pathogen Vibrio anguillarum.
Discovery of RUF6 ncRNA–interacting proteins involved in P. falciparum immune evasionAn RNA-directed proteomic discovery (ChIRP-MS) protocol is used to identify in vivo RUF6 ncRNA–protein interactions that sustain virulence genes in the human malaria parasite, Plasmodium falciparum.