Microbiology, Virology & Host Pathogen Interaction
Low-density lipoprotein receptor–related protein 1 (LRP1) as an auxiliary host factor for RNA virusesPlasma membrane–located low-density lipoprotein receptor–related protein 1 (LRP1 or CD91) is a host factor that supports the early infection stages of a spectrum of RNA viruses.
The pro-inflammatory response to influenza A virus infection is fueled by endothelial cellsA co-culture model of human primary endothelial cells and organoid-derived epithelial cells shows that endothelial cells are abortively infected by influenza A virus but can drive the pro-inflammatory response.
Intranasal soluble ACE2 improves survival and prevents brain SARS-CoV-2 infectionA soluble ACE2 protein bioengineered to have extended duration of action and enhanced affinity for SARS-CoV-2 provides markedly improved survival and organ protection when administered intranasally. Reducing brain SARS-CoV-2 titers is an important determinant of therapeutic efficacy.
RopB represses the transcription of speB in the absence of SIP in group A StreptococcusSIP-free RopB, in contrast to SpeB-inducing peptide (SIP)-bound RopB, is a transcriptional repressor of speB and mediates speB repression in the covS mutant.
FBXO11 governs macrophage cell death and inflammation in response to bacterial toxinsFBXO11 regulates the expression of the complement receptor C5aR1 and the inflammatory cytokine IL-1β, affecting how macrophages respond to Staphylococcus aureus pore–forming toxins.
Reduced replication but increased interferon resistance of SARS-CoV-2 Omicron BA.1The SARS-CoV-2 Omicron BA.1 variant of concern is highly resistant against exogenous interferons, suggesting that effective innate immune evasion contributed to its success.
Characterisation of the OTU domain deubiquitinase complement of Toxoplasma gondiiThe OTU deubiquitinase family is expanded in Toxoplasma parasites, and members show preferences for Lys6-, Lys11-, Lys48-, and Lys63-linked ubiquitin chains, and additional specificity for NEDD8. AlphaFold-guided structural analysis reveals cryptic ubiquitin-binding domains with functional importance.
Potency assessment of IFNγ-producing SARS-CoV-2-specific T cells from COVID-19 convalescent subjectsSARS-CoV-2-specific T-cells from convalescent donors present phenotypical and functional characteristics that make them a suitable candidate for a future development of an advanced cellular therapy.
Genomic insights into antibiotic resistance and mobilome of lactic acid bacteria and bifidobacteriaWhole-genome sequencing is used to discover novel potential mechanisms of antimicrobial resistance and mobile genetic elements in lactic acid bacteria and bifidobacteria from the agro-food chain.
Tannins amount determines whether tannase-containing bacteria are probiotic or pathogenic in IBDTA-induced microbial metabolite GA displays dual effects on IBD. GA exerts its function through two ways: influence bacteria penetration and directly affect epithelial cells. Interaction between diet and microbial enzyme is pivotal in affecting IBD.