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Microbiology, Virology & Host Pathogen Interaction

  • Dimerization and auto-processing induce caspase-11 protease activation within the non-canonical inflammasome
    Open Access
    Dimerization and auto-processing induce caspase-11 protease activation within the non-canonical inflammasome

    Connie Ross, Amy H Chan, Jessica Von Pein, Dave Boucher, Kate Schroder

    Connie Ross ... Kate Schroder

    Published 6 December 2018

    This study provides a detailed molecular mechanism for caspase-11 activation within the non-canonical inflammasome, giving new insight into host defence against cytosolic bacterial infection.

  • Identification of <em>Plasmodium</em> GAPDH epitopes for generation of antibodies that inhibit malaria infection
    Open Access
    Identification of Plasmodium GAPDH epitopes for generation of antibodies that inhibit malaria infection

    Sung-Jae Cha, Kyle Jarrod McLean, Marcelo Jacobs-Lorena

    Sung-Jae Cha ... Marcelo Jacobs-Lorena

    Published 18 September 2018

    This study reports on the identification of two Plasmodium GAPDH epitope peptides that are responsible for sporozoite–Kupffer cell interaction and act as antigens against malaria infection.

  • RNase E cleavage shapes the transcriptome of <em>Rhodobacter sphaeroides</em> and strongly impacts phototrophic growth
    Open Access
    RNase E cleavage shapes the transcriptome of Rhodobacter sphaeroides and strongly impacts phototrophic growth

    Konrad U Förstner, Carina M Reuscher, Kerstin Haberzettl, Lennart Weber, Gabriele Klug

    Konrad U Förstner ... Gabriele Klug

    Published 1 August 2018

    This study identifies the cleavage sites of the endoribonuclease RNase E in the Rhodobacter sphaeroides transcriptome and demonstrates its effect on oxidative stress resistance and phototrophic growth.

  • Proteins of generalist and specialist pathogens differ in their amino acid composition
    Open Access
    Proteins of generalist and specialist pathogens differ in their amino acid composition

    Luz P Blanco, Bryan L Payne, Felix Feyertag, David Alvarez-Ponce

    Luz P Blanco ... David Alvarez-Ponce

    Published 17 July 2018

    Primitive amino acids and disorder content in secreted proteins are distinctively enriched in generalist compared with host-specific pathogens.

  • Discovery of a cofactor-independent inhibitor of <em>Mycobacterium tuberculosis</em> InhA
    Open Access
    Discovery of a cofactor-independent inhibitor of Mycobacterium tuberculosis InhA

    Yi Xia, Yasheen Zhou, David S Carter, Matthew B McNeil, Wai Choi, Jason Halladay, Pamela W Berry, Weimin Mao, Vincent Hernandez, Theresa O'Malley, Aaron Korkegian, Bjorn Sunde, Lindsay Flint, Lisa K Woolhiser, Michael S Scherman, Veronica Gruppo, Courtney Hastings, Gregory T Robertson, Thomas R Ioerger, Jim Sacchettini, Peter J Tonge, Anne J Lenaerts, Tanya Parish, MRK Alley

    Yi Xia ... MRK Alley

    Published 1 June 2018

    AN12855 is a novel cofactor-independent inhibitor of Mycobacterium tuberculosis InhA. AN12855 has potent activity against M. tuberculosis, good oral bioavailability, and comparable efficacy to isoniazid in infection models.

  • The <em>Arabidopsis</em> homolog of human G3BP1 is a key regulator of stomatal and apoplastic immunity
    Open Access
    The Arabidopsis homolog of human G3BP1 is a key regulator of stomatal and apoplastic immunity

    Aala A Abulfaraj, Kiruthiga Mariappan, Jean Bigeard, Prabhu Manickam, Ikram Blilou, Xiujie Guo, Salim Al-Babili, Delphine Pflieger, Heribert Hirt, Naganand Rayapuram

    Aala A Abulfaraj ... Naganand Rayapuram

    Published 31 May 2018

    Arabidopsis homolog of human G3BP1 negatively regulates plant immunity and defense responses. Atg3bp1 mutant lines show constitutive stomata closure, expression of a number of key defense marker genes, and accumulate salicylic acid.

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