Microbiology, Virology & Host Pathogen Interaction
Peptide derived from SLAMF1 prevents TLR4-mediated inflammation in vitro and in vivoSLAMF1-derived peptide P7 inhibits TLR4-mediated signaling and prevents animal death in mice subjected to LPS shock by blocking TIRAP–MyD88 interaction and TRAM recruitment to TLR4.
Comparative analysis of bioinformatics tools to characterize SARS-CoV-2 subgenomic RNAsThis study compares the performances of three different software in the identification of canonical and noncanonical sgRNAs in amplicon data sequenced with Illumina MiSeq in 250-bp paired ends.
The arginine methyltransferase PRMT5 promotes mucosal defense in the intestineArginine methyltransferase PRMT5 promotes select colonic goblet cell-associated gene programs and facilitates host defense against enteric pathogens.
Polo-like kinase-1 mediates hepatitis C virus-induced cell migration, a drug target for liver cancerThis study identifies PLK1 as a novel protein that promotes liver cancer in people with hepatitis C. The findings suggest a novel drug target for patients with liver cancer to reduce cancer spread and improve survival.
High-resolution kinetic characterization of the RIG-I-signaling pathway and the antiviral responseThis study takes a comprehensive approach to understand the dynamics of the cell-intrinsic response towards virus infection and how viruses actively modulate this.
Caspase-4 dimerisation and D289 auto-processing elicit an interleukin-1β-converting enzymeThe noncanonical inflammasome generates p32/p9 and p34/p9 active caspase-4 species via dimerisation and autocleavage; both species cleave GSDMD to induce pyroptosis, whereas p34/p9 matures IL-1β.
Disulfide stabilization reveals conserved dynamic features between SARS-CoV-1 and SARS-CoV-2 spikesSARS-CoV-1 spike protein is stabilized with engineered disulfide bonds, and cryo-EM imaging of these stabilized S-trimers reveals rare spike conformations.
SLIT2/ROBO1 signaling suppresses mTORC1 for organelle control and bacterial killingSLIT2, a canonical neurorepellent, promotes lysosome biogenesis and augments autophagic flux to modulate immune responses in macrophages. In cancer cells, SLIT2 negatively regulates mTORC1 signaling to control cell growth.
STING is redundant for host defense and pathology of COVID-19-like disease in miceSTING-deficient mice infected with SARS-CoV-2 do not show altered disease development or viral load, nor any major differences in inflammatory responses.
Amphid sensory neurons of Caenorhabditis elegans orchestrate its survival from infection with broad classes of pathogensThis study shows that the nervous system of the bacterivorous nematode Caenorhabditis elegans coordinates pathogen-specific and broad immune responses during infection.