Microbiology, Virology & Host Pathogen Interaction
Genome-wide profiling of histone modifications in Plasmodium falciparum using CUT&RUNWe present a detailed step-wise protocol for reliable genome-wide profiling of histone modifications using CUT&RUN that requires only low numbers of Plasmodium falciparum blood stages.
The potential of a universal influenza virus-like particle vaccine expressing a chimeric cytokineHerein, a virus-like particle vaccine with chimeric cytokine shows the protective efficacy against different strains of influenza virus, laying the foundation for designing a universal influenza vaccine.
Low expression of EXOSC2 protects against clinical COVID-19 and impedes SARS-CoV-2 replicationGenetic evidence and in vitro experiments with live virus suggest EXOSC2 depletion can reduce SARS-CoV-2 replication without significant toxicity.
Contribution of the Golgi apparatus in morphogenesis of a virus-induced cytopathic vacuolar systemElectron tomography reveals four classes of cytopathic vesicles-II (CPV-II) stemming from the host Golgi apparatus after Venezuelan equine encephalitis virus infection.
Binding stoichiometry and structural model of the HIV-1 Rev/importin β complexBiochemical, biophysical, and docking studies provide insights into how the HIV-1 regulatory protein Rev is recognized by the nuclear import factor importin beta.
Efficacy of SARS-CoV-2 vaccination in patients with monoclonal gammopathies: A cross sectional studyUninfected multiple myeloma patients do not develop adequate immunity after SARS-COV-2 vaccination and will clearly benefit from tailored monitoring of immune responses after booster vaccine doses.
Human milk inhibits some enveloped virus infections, including SARS-CoV-2, in an intestinal modelHuman milk blocks some enveloped, but not non-enveloped, virus infections in a primary human fetal intestinal model and the transcriptomic data points towards inhibition of entry mediated by ATP1A1.
- Correction: Transmembrane protease serine 2 (TMPRSS2) rs75603675, comorbidity and sex are the primary predictors of Covid-19 severity
We identified an error in the abstract of the article: TPMRSS2 rs75603675 OR is incorrectly indicated. It should read (OR = 2.140) instead of (OR = 0.586).
Transmembrane protease serine 2 (TMPRSS2) rs75603675, comorbidity, and sex are the primary predictors of COVID-19 severityThe TMPRSS2 rs75603675 genotype (OR = 0.586), dyslipidemia (OR = 2.289), sex (OR = 0.586), and the Charlson Comorbidity Index (OR = 1.126) were identified as the main predictors of COVID-19 severity in 817 patients who attended Hospital Universitario de La Princesa during March and April 2020.
OXSR1 inhibits inflammasome activation by limiting potassium efflux during mycobacterial infectionMycobacteria up-regulate host kinase OXSR1 preventing potassium efflux and inflammasome activation. Depletion or inhibition of OXSR1 potentiates inflammasome activation and decreases bacterial burden.