Skip to main content
Advertisement

Main menu

  • Home
  • Articles
    • Newest Articles
    • Current Issue
    • Archive
    • Subjects
  • Submit
    • Submit a Manuscript
    • Author Guidelines
    • License, Copyright, Fee
    • FAQ
    • Why Submit
  • About
    • About Us
    • Editors & Staff
    • Board Members
    • Licensing and Reuse
    • Reviewer Guidelines
    • Privacy Policy
    • Advertise
    • Contact Us
    • LSA LLC
  • Alerts
  • Other Publications
    • EMBO Press
    • The EMBO Journal
    • EMBO reports
    • EMBO Molecular Medicine
    • Molecular Systems Biology
    • Rockefeller University Press
    • Journal of Cell Biology
    • Journal of Experimental Medicine
    • Journal of General Physiology
    • Cold Spring Harbor Laboratory Press
    • Genes & Development
    • Genome Research

User menu

  • My alerts

Search

  • Advanced search
Life Science Alliance
  • Other Publications
    • EMBO Press
    • The EMBO Journal
    • EMBO reports
    • EMBO Molecular Medicine
    • Molecular Systems Biology
    • Rockefeller University Press
    • Journal of Cell Biology
    • Journal of Experimental Medicine
    • Journal of General Physiology
    • Cold Spring Harbor Laboratory Press
    • Genes & Development
    • Genome Research
  • My alerts
Life Science Alliance

Advanced Search

  • Home
  • Articles
    • Newest Articles
    • Current Issue
    • Archive
    • Subjects
  • Submit
    • Submit a Manuscript
    • Author Guidelines
    • License, Copyright, Fee
    • FAQ
    • Why Submit
  • About
    • About Us
    • Editors & Staff
    • Board Members
    • Licensing and Reuse
    • Reviewer Guidelines
    • Privacy Policy
    • Advertise
    • Contact Us
    • LSA LLC
  • Alerts
  • Follow lsa Template on Twitter

Microbiology, Virology & Host Pathogen Interaction

  • Evidence for vesicle-mediated antigen export by the human pathogen <em>Babesia microti</em>
    Open Access
    Evidence for vesicle-mediated antigen export by the human pathogen Babesia microti

    Jose Thekkiniath, Nicole Kilian, Lauren Lawres, Meital A Gewirtz, Morven M Graham, Xinran Liu, Michel Ledizet, Choukri Ben Mamoun

    Jose Thekkiniath ... Choukri Ben Mamoun

    Published 13 June 2019

    The human pathogen Babesia microti undergoes unique morphogenesis during its development within human and mouse red blood cells and uses a novel vesicle-based system for export of antigens into the host cell and environment.

  • PKAc is not required for the preerythrocytic stages of <em>Plasmodium berghei</em>
    Open Access
    PKAc is not required for the preerythrocytic stages of Plasmodium berghei

    Hadi Hasan Choudhary, Roshni Gupta, Satish Mishra

    Hadi Hasan Choudhary ... Satish Mishra

    Published 29 May 2019

    The mutant salivary gland sporozoites lacking PKAc are able to glide, invade hepatocytes, and mature into hepatic merozoites, which release successfully from the merosome, however, fail to initiate blood stage infection when inoculated into mice.

  • The <em>S</em>. Typhi effector StoD is an E3/E4 ubiquitin ligase which binds K48- and K63-linked diubiquitin
    Open Access
    The S. Typhi effector StoD is an E3/E4 ubiquitin ligase which binds K48- and K63-linked diubiquitin

    Melanie A McDowell, Alexander MP Byrne, Elli Mylona, Rebecca Johnson, Agnes Sagfors, Valerie F Crepin, Susan Lea, Gad Frankel

    Melanie A McDowell ... Gad Frankel

    Published 29 May 2019

    Salmonella Typhi is estimated to cause 100,000–200,000 deaths annually, yet its infection strategy remains elusive. This article reports of the first Typhi-specific effector, which has an E3/E4 ubiquitin ligase activity and can uniquely bind K48- and K63-linked diubiquitin.

  • Constitutive STAT5 activation regulates Paneth and Paneth-like cells to control <em>Clostridium difficile</em> colitis
    Open Access
    Constitutive STAT5 activation regulates Paneth and Paneth-like cells to control Clostridium difficile colitis

    Ruixue Liu, Richard Moriggl, Dongsheng Zhang, Haifeng Li, Rebekah Karns, Hai-Bin Ruan, Haitao Niu, Christopher Mayhew, Carey Watson, Hansraj Bangar, Sang-wook Cha, David Haslam, Tongli Zhang, Shila Gilbert, Na Li, Michael Helmrath, James Wells, Lee Denson, Xiaonan Han

    Ruixue Liu ... Xiaonan Han

    Published 4 April 2019

    STAT5 controls the intestinal epithelial stem cell niche by regulating Wnt/β-catenin signaling, and lack of active pYSTAT5 induces Clostridium difficile infection. STAT5 may be a transcription factor that restricts niche cell differentiation.

  • BZLF1 interacts with chromatin remodelers promoting escape from latent infections with EBV
    Open Access
    BZLF1 interacts with chromatin remodelers promoting escape from latent infections with EBV

    Marisa Schaeffner, Paulina Mrozek-Gorska, Alexander Buschle, Anne Woellmer, Takanobu Tagawa, Filippo M. Cernilogar, Gunnar Schotta, Nils Krietenstein, Corinna Lieleg, Philipp Korber, Wolfgang Hammerschmidt

    Marisa Schaeffner ... Wolfgang Hammerschmidt

    Published 29 March 2019

    How herpesviruses escape from their latent states is enigmatic, but BZLF1, an important transcription factor of EBV, recruits cellular chromatin remodelers to viral DNA to overcome its epigenetic repression and initiate viral transcription.

  • A dual role for SAMHD1 in regulating HBV cccDNA and RT-dependent particle genesis
    Open Access
    A dual role for SAMHD1 in regulating HBV cccDNA and RT-dependent particle genesis

    Peter AC Wing, Tamara Davenne, Jochen Wettengel, Alvina G Lai, Xiaodong Zhuang, Anindita Chakraborty, Valentina D’Arienzo, Catharina Kramer, Chunkyu Ko, James M Harris, Sabrina Schreiner, Martin Higgs, Stephanie Roessler, Joanna L Parish, Ulrike Protzer, Peter Balfe, Jan Rehwinkel, Jane A McKeating

    Peter AC Wing ... Jane A McKeating

    Published 27 March 2019

    Our study highlights a dual role for SAMHD1 in regulating hepatitis B virus cccDNA levels and reverse transcriptase–dependent particle genesis.

  • Functional inhibition of acid sphingomyelinase disrupts infection by intracellular bacterial pathogens
    Open Access
    Functional inhibition of acid sphingomyelinase disrupts infection by intracellular bacterial pathogens

    Chelsea L Cockburn, Ryan S Green, Sheela R Damle, Rebecca K Martin, Naomi N Ghahrai, Punsiri M Colonne, Marissa S Fullerton, Daniel H Conrad, Charles E Chalfant, Daniel E Voth, Elizabeth A Rucks, Stacey D Gilk, Jason A Carlyon

    Chelsea L Cockburn ... Jason A Carlyon

    Published 22 March 2019

    Many intracellular pathogens hijack cholesterol. Inhibiting acid sphingomyelinase alters cholesterol traffic to target different intracellular bacteria, signifying a host-directed approach for treating infectious disease.

  • <em>Viperin</em> controls chikungunya virus–specific pathogenic T cell IFNγ Th1 stimulation in mice
    Open Access
    Viperin controls chikungunya virus–specific pathogenic T cell IFNγ Th1 stimulation in mice

    Guillaume Carissimo, Teck-Hui Teo, Yi-Hao Chan, Cheryl Yi-Pin Lee, Bernett Lee, Anthony Torres-Ruesta, Jeslin JL Tan, Tze-Kwang Chua, Siew-Wai Fong, Fok-Moon Lum, Lisa FP Ng

    Guillaume Carissimo ... Lisa FP Ng

    Published 21 January 2019

    This study shows that Viperin controls the microenvironment pro-inflammatory response and CD4 T cell–mediated pathogenesis during anti-chikungunya virus immune response in mice.

  • Rab1b and ARF5 are novel RNA-binding proteins involved in FMDV IRES–driven RNA localization
    Open Access
    Rab1b and ARF5 are novel RNA-binding proteins involved in FMDV IRES–driven RNA localization

    Javier Fernandez-Chamorro, Rosario Francisco-Velilla, Jorge Ramajo, Encarnación Martinez-Salas

    Javier Fernandez-Chamorro ... Encarnación Martinez-Salas

    Published 17 January 2019

    Integration of proteomic data with functional and imaging analysis revealed that Rab1b and ARF5, two ER-Golgi members, are RNA-binding proteins that colocalize with picornavirus IRES-RNA reporters in human cells.

  • Mechanistic aspects of maltotriose-conjugate translocation to the Gram-negative bacteria cytoplasm
    Open Access
    Mechanistic aspects of maltotriose-conjugate translocation to the Gram-negative bacteria cytoplasm

    Estelle Dumont, Julia Vergalli, Jelena Pajovic, Satya P Bhamidimarri, Koldo Morante, Jiajun Wang, Dmitrijs Lubriks, Edgars Suna, Robert A Stavenger, Mathias Winterhalter, Matthieu Réfrégiers, Jean-Marie Pagès

    Estelle Dumont ... Jean-Marie Pagès

    Published 28 December 2018

    A maltotriose-conjugate can deliver molecules into the cytoplasmic space of Gram-negative bacteria by parasitizing the maltose uptake pathway.

Pages

  • Previous
  • Next
  • 1
  • 2
  • 3
  • 4
  • 5
  • Aging (10)
  • Biophysics (14)
  • Cancer (67)
  • Cell Biology (147)
  • Chemical Biology (7)
  • Chromatin & Epigenetics (31)
  • Development (28)
  • Ecology (1)
  • Evolution (10)
  • Genetics, Gene Therapy & Genetic Disease (32)
  • Genomics & Functional Genomics (45)
  • Immunology (62)
  • Medical Research (31)
  • Metabolism (22)
  • Methods & Resources (24)
  • Microbiology, Virology & Host Pathogen Interaction (46)
  • Molecular Biology (98)
  • Molecular Diagnostics & Diagnostic Imaging (2)
  • Neuroscience (36)
  • Pharmacology & Biotechnology (8)
  • Physiology (11)
  • Plant Science (11)
  • Stem Cells (25)
  • Structural Biology (27)
  • Synthetic Biology (2)
  • Systems & Computational Biology (36)
Advertisement

EMBO Press LogoRockefeller University Press LogoCold Spring Harbor Logo

Content

  • Home
  • Newest Articles
  • Current Issue
  • Archive
  • Subject Collections

For Authors

  • Submit a Manuscript
  • Author Guidelines
  • License, copyright, Fee

Other Services

  • Alerts
  • Twitter
  • RSS Feeds

More Information

  • Editors & Staff
  • Reviewer Guidelines
  • Feedback
  • Licensing and Reuse
  • Privacy Policy

ISSN: 2575-1077
© 2021 Life Science Alliance LLC

Life Science Alliance is registered as a trademark in the U.S. Patent and Trade Mark Office and in the European Union Intellectual Property Office.