Microbiology, Virology & Host Pathogen Interaction
E. hellem Ser/Thr protein phosphatase PP1 targets the DC MAPK pathway and impairs immune functionsIntracellular pathogen E. hellem suppressed host DCs’ immune functions via pathogen-derived serine/threonine protein phosphatase PP1 directly targeting the host p38α/MAPK pathway.
2′,3′ cyclic nucleotide 3′ phosphodiesterase 1 functional isoform antagonizes HIV-1 particle assemblyCNP1, not CNP2, is the primary isoform inhibiting HIV-1, highlighting posttranslational regulation in CNP antiviral role.
Sterile protection against P. vivax malaria by repeated blood stage infection in the Aotus monkey modelRepeated blood stage infections with the human malaria parasite, Plasmodium vivax, induce sterile strain-specific and partial strain-transcendent protection in the Aotus monkey model.
The structural basis for deubiquitination by the fingerless USP-type effector TssMThe structural characterization of the bacterial effector deubiquitinase TssM from Burkholderia pseudomallei, belonging to the USP family, reveals that TssM lacks the canonical “Fingers” subdomain of USP-type deubiquitinases and evolved instead the functionally analog “Littlefinger” loop for ubiquitin binding.
FAT10 is phosphorylated by IKKβ to inhibit the antiviral type-I interferon responseIKKβ-mediated phosphorylation of FAT10 dampens the antiviral type I interferon response by stabilizing OTUB1.
Suppressed transcript diversity and immune response in COVID-19 ICU patients: a longitudinal studyThis integrative longitudinal clinico-genomic study delves deep into the gene and transcript expression pattern dynamics in severe COVID-19 patients with ARDS admitted to the ICU.
Peptide derived from SLAMF1 prevents TLR4-mediated inflammation in vitro and in vivoSLAMF1-derived peptide P7 inhibits TLR4-mediated signaling and prevents animal death in mice subjected to LPS shock by blocking TIRAP–MyD88 interaction and TRAM recruitment to TLR4.
Comparative analysis of bioinformatics tools to characterize SARS-CoV-2 subgenomic RNAsThis study compares the performances of three different software in the identification of canonical and noncanonical sgRNAs in amplicon data sequenced with Illumina MiSeq in 250-bp paired ends.
The arginine methyltransferase PRMT5 promotes mucosal defense in the intestineArginine methyltransferase PRMT5 promotes select colonic goblet cell-associated gene programs and facilitates host defense against enteric pathogens.
Polo-like kinase-1 mediates hepatitis C virus-induced cell migration, a drug target for liver cancerThis study identifies PLK1 as a novel protein that promotes liver cancer in people with hepatitis C. The findings suggest a novel drug target for patients with liver cancer to reduce cancer spread and improve survival.