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Microbiology, Virology & Host Pathogen Interaction

  • Initial phospholipid-dependent Irgb6 targeting to <em>Toxoplasma gondii</em> vacuoles mediates host defense
    Open Access
    Initial phospholipid-dependent Irgb6 targeting to Toxoplasma gondii vacuoles mediates host defense

    Youngae Lee, Hiroshi Yamada, Ariel Pradipta, Ji Su Ma, Masaaki Okamoto, Hikaru Nagaoka, Eizo Takashima, Daron M Standley, Miwa Sasai, Kohji Takei, Masahiro Yamamoto

    Youngae Lee ... Masahiro Yamamoto

    Published 18 December 2019

    Irgb6 has a role in the cell-autonomous response against T. gondii and involves ubiquitination and breakdown of vacuoles via binding of a specific phospholipid on the parasitophorous vacuole membrane.

  • Bat IFITM3 restriction depends on S-palmitoylation and a polymorphic site within the CD225 domain
    Open Access
    Bat IFITM3 restriction depends on S-palmitoylation and a polymorphic site within the CD225 domain

    Camilla TO Benfield, Farrell MacKenzie, Markus Ritzefeld, Michela Mazzon, Stuart Weston, Edward W Tate, Boon Han Teo, Sarah E Smith, Paul Kellam, Edward C Holmes, Mark Marsh

    Camilla TO Benfield ... Mark Marsh

    Published 11 December 2019

    Comparative analysis reveals adaptive evolution of bat IFITMs and a naturally polymorphic site within the conserved CD225 domain that affects S-palmitoylation and antiviral function of bat IFITM3.

  • ADAPTABLE: a comprehensive web platform of antimicrobial peptides tailored to the user’s research
    Open Access
    ADAPTABLE: a comprehensive web platform of antimicrobial peptides tailored to the user’s research

    Francisco Ramos-Martín, Thibault Annaval, Sébastien Buchoux, Catherine Sarazin, Nicola D’Amelio

    Francisco Ramos-Martín ... Nicola D’Amelio

    Published 18 November 2019

    ADAPTABLE is a webserver and database of antimicrobial peptides that uses sequence and property alignment to highlight their mode of action against the threat of resistance in medicine and agriculture.

  • <em>Pseudomonas aeruginosa</em> lectin LecB impairs keratinocyte fitness by abrogating growth factor signalling
    Open Access
    Pseudomonas aeruginosa lectin LecB impairs keratinocyte fitness by abrogating growth factor signalling

    Alessia Landi, Muriel Mari, Svenja Kleiser, Tobias Wolf, Christine Gretzmeier, Isabel Wilhelm, Dimitra Kiritsi, Roland Thünauer, Roger Geiger, Alexander Nyström, Fulvio Reggiori, Julie Claudinon, Winfried Römer

    Alessia Landi ... Winfried Römer

    Published 15 November 2019

    This study provides a novel function of the bacterial lectin LecB, which dampens cell proliferation and survival by targeting the insulin-like growth factor-1 for degradation, without receptor activation.

  • Thymosin β4 promotes autophagy and repair via HIF-1α stabilization in chronic granulomatous disease
    Open Access
    Thymosin β4 promotes autophagy and repair via HIF-1α stabilization in chronic granulomatous disease

    Giorgia Renga, Vasilis Oikonomou, Silvia Moretti, Claudia Stincardini, Marina M Bellet, Marilena Pariano, Andrea Bartoli, Stefano Brancorsini, Paolo Mosci, Andrea Finocchi, Paolo Rossi, Claudio Costantini, Enrico Garaci, Allan L Goldstein, Luigina Romani

    Giorgia Renga ... Luigina Romani

    Published 12 November 2019

    This study demonstrates that thymosin β4 stabilizes HIF-1a to promote autophagy and up-regulate genes involved in tissue and mucosal barrier protection in chronic granulomatous disease.

  • Conservation of cell-intrinsic immune responses in diverse nonhuman primate species
    Open Access
    Conservation of cell-intrinsic immune responses in diverse nonhuman primate species

    Jenna M Gaska, Lance Parsons, Metodi Balev, Ann Cirincione, Wei Wang, Robert E Schwartz, Alexander Ploss

    Jenna M Gaska ... Alexander Ploss

    Published 24 October 2019

    The transcriptomic response of diverse nonhuman primate (NHP) species to poly(I:C) is highly conserved, and this novel RNA sequencing dataset will help improve NHP genome annotations.

  • XIAP controls RIPK2 signaling by preventing its deposition in speck-like structures
    Open Access
    XIAP controls RIPK2 signaling by preventing its deposition in speck-like structures

    Kornelia Ellwanger, Selina Briese, Christine Arnold, Ioannis Kienes, Valentin Heim, Ueli Nachbur, Thomas A Kufer

    Kornelia Ellwanger ... Thomas A Kufer

    Published 26 July 2019

    This study provides evidence that the NOD1/2-associated kinase RIPK2 localizes to detergent insoluble cytosolic complexes upon activation and suggests novel regulatory mechanisms for RIPK2 signaling.

  • Assembly mechanisms of the bacterial cytoskeletal protein FilP
    Open Access
    Assembly mechanisms of the bacterial cytoskeletal protein FilP

    Ala Javadi, Niklas Söderholm, Annelie Olofsson, Klas Flärdh, Linda Sandblad

    Ala Javadi ... Linda Sandblad

    Published 26 June 2019

    FilP is a coiled-coil protein that self-assembles into striated filaments and meshwork that shares structural and biochemical characteristics with metazoan intermediate filaments.

  • Tamoxifen blocks retrograde trafficking of Shiga toxin 1 and 2 and protects against lethal toxicosis
    Open Access
    Tamoxifen blocks retrograde trafficking of Shiga toxin 1 and 2 and protects against lethal toxicosis

    Andrey S Selyunin, Steven Hutchens, Stanton F McHardy, Somshuvra Mukhopadhyay

    Andrey S Selyunin ... Somshuvra Mukhopadhyay

    Published 26 June 2019

    This study reports an unexpected role of late endosome–lysosome fusion in early endosome-to-Golgi trafficking of Shiga toxins and identifies tamoxifen to be a potent inhibitor of Shiga toxicosis.

  • An unusual and vital protein with guanylate cyclase and P4-ATPase domains in a pathogenic protist
    Open Access
    An unusual and vital protein with guanylate cyclase and P4-ATPase domains in a pathogenic protist

    Özlem Günay-Esiyok, Ulrike Scheib, Matthias Noll, Nishith Gupta

    Özlem Günay-Esiyok ... Nishith Gupta

    Published 24 June 2019

    Toxoplasma gondii harbors an alveolate-specific guanylate cyclase linked to P-type ATPase motifs, which is an essential actuator of cGMP-dependent gliding motility, egress, and invasion during acute infection.

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