Microbiology, Virology & Host Pathogen Interaction
- Initial phospholipid-dependent Irgb6 targeting to Toxoplasma gondii vacuoles mediates host defense
Irgb6 has a role in the cell-autonomous response against T. gondii and involves ubiquitination and breakdown of vacuoles via binding of a specific phospholipid on the parasitophorous vacuole membrane.
- Bat IFITM3 restriction depends on S-palmitoylation and a polymorphic site within the CD225 domain
Comparative analysis reveals adaptive evolution of bat IFITMs and a naturally polymorphic site within the conserved CD225 domain that affects S-palmitoylation and antiviral function of bat IFITM3.
- ADAPTABLE: a comprehensive web platform of antimicrobial peptides tailored to the user’s research
ADAPTABLE is a webserver and database of antimicrobial peptides that uses sequence and property alignment to highlight their mode of action against the threat of resistance in medicine and agriculture.
- Pseudomonas aeruginosa lectin LecB impairs keratinocyte fitness by abrogating growth factor signalling
This study provides a novel function of the bacterial lectin LecB, which dampens cell proliferation and survival by targeting the insulin-like growth factor-1 for degradation, without receptor activation.
- Thymosin β4 promotes autophagy and repair via HIF-1α stabilization in chronic granulomatous disease
This study demonstrates that thymosin β4 stabilizes HIF-1a to promote autophagy and up-regulate genes involved in tissue and mucosal barrier protection in chronic granulomatous disease.
- Conservation of cell-intrinsic immune responses in diverse nonhuman primate species
The transcriptomic response of diverse nonhuman primate (NHP) species to poly(I:C) is highly conserved, and this novel RNA sequencing dataset will help improve NHP genome annotations.
- XIAP controls RIPK2 signaling by preventing its deposition in speck-like structures
This study provides evidence that the NOD1/2-associated kinase RIPK2 localizes to detergent insoluble cytosolic complexes upon activation and suggests novel regulatory mechanisms for RIPK2 signaling.
- Assembly mechanisms of the bacterial cytoskeletal protein FilP
FilP is a coiled-coil protein that self-assembles into striated filaments and meshwork that shares structural and biochemical characteristics with metazoan intermediate filaments.
- Tamoxifen blocks retrograde trafficking of Shiga toxin 1 and 2 and protects against lethal toxicosis
This study reports an unexpected role of late endosome–lysosome fusion in early endosome-to-Golgi trafficking of Shiga toxins and identifies tamoxifen to be a potent inhibitor of Shiga toxicosis.
- An unusual and vital protein with guanylate cyclase and P4-ATPase domains in a pathogenic protist
Toxoplasma gondii harbors an alveolate-specific guanylate cyclase linked to P-type ATPase motifs, which is an essential actuator of cGMP-dependent gliding motility, egress, and invasion during acute infection.