Microbiology, Virology & Host Pathogen Interaction
Inflammatory markers for improved recurrent UTI diagnosis in postmenopausal womenHere, we identify urinary cytokines that are differentially abundant in postmenopausal women with symptomatic recurrent UTI compared with controls and evaluate their ability to accurately diagnose UTI.
Stability of gut microbiome after COVID-19 vaccination in healthy and immuno-compromised individualsThis study highlights the resilience of the gut microbiome to host immune changes triggered by COVID-19 vaccination and suggest minimal, if any, impact on microbiome-mediated processes.
Zebrafish tsc1 and cxcl12a increase susceptibility to mycobacterial infectionKnockdown of miR-126 increases susceptibility to mycobacterial infection which can be independently reversed by targeting Tsc1/mTOR or ccr2 implicating macrophage function.
Integrated analysis of RNA-seq datasets reveals novel targets and regulators of COVID-19 severityThis work observed differential expression of genes related to the endomembrane system, specific granules, T cell receptor complex, and SPI1 and TP53 target genes exclusively in severe COVID-19 patients.
E. hellem Ser/Thr protein phosphatase PP1 targets the DC MAPK pathway and impairs immune functionsIntracellular pathogen E. hellem suppressed host DCs’ immune functions via pathogen-derived serine/threonine protein phosphatase PP1 directly targeting the host p38α/MAPK pathway.
2′,3′ cyclic nucleotide 3′ phosphodiesterase 1 functional isoform antagonizes HIV-1 particle assemblyCNP1, not CNP2, is the primary isoform inhibiting HIV-1, highlighting posttranslational regulation in CNP antiviral role.
Sterile protection against P. vivax malaria by repeated blood stage infection in the Aotus monkey modelRepeated blood stage infections with the human malaria parasite, Plasmodium vivax, induce sterile strain-specific and partial strain-transcendent protection in the Aotus monkey model.
The structural basis for deubiquitination by the fingerless USP-type effector TssMThe structural characterization of the bacterial effector deubiquitinase TssM from Burkholderia pseudomallei, belonging to the USP family, reveals that TssM lacks the canonical “Fingers” subdomain of USP-type deubiquitinases and evolved instead the functionally analog “Littlefinger” loop for ubiquitin binding.
FAT10 is phosphorylated by IKKβ to inhibit the antiviral type-I interferon responseIKKβ-mediated phosphorylation of FAT10 dampens the antiviral type I interferon response by stabilizing OTUB1.
Suppressed transcript diversity and immune response in COVID-19 ICU patients: a longitudinal studyThis integrative longitudinal clinico-genomic study delves deep into the gene and transcript expression pattern dynamics in severe COVID-19 patients with ARDS admitted to the ICU.