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Microbiology, Virology & Host Pathogen Interaction

  • <em>Helicobacter pylori</em> induces the expression of Lgr5 and stem cell properties in gastric target cells
    Open Access
    Helicobacter pylori induces the expression of Lgr5 and stem cell properties in gastric target cells

    Zuzana Nascakova, Jiazhuo He, Giovanni Papa, Biel Francas, Flora Azizi, Anne Müller

    Zuzana Nascakova ... Anne Müller

    Published 27 August 2024

    Helicobacter pylori infection induces Lgr5 expression and stem cell properties in its target cells in a type IV secretion system/NF-kB-dependent manner. This effect on stemness is exacerbated by constitutive Wnt pathway activation and persists after antibiotic eradication.

  • Transcriptional and methylation outcomes of didehydro-cortistatin A use in HIV-1–infected CD4<sup>+</sup> T cells
    Open Access
    Transcriptional and methylation outcomes of didehydro-cortistatin A use in HIV-1–infected CD4+ T cells

    Luisa P Mori, Michael J Corley, Andrew T McAuley, Alina Pang, Thomas Venables, Lishomwa C Ndhlovu, Matthew E Pipkin, Susana T Valente

    Luisa P Mori ... Susana T Valente

    Published 1 August 2024

    The HIV-1 Tat inhibitor didehydro-cortistatin A not only blocks HIV-1 transcription but also induces specific transcriptional and epigenetic changes in CD4+ T cells, promoting a tolerogenic Treg/Th2 phenotype and reducing inflammatory gene expression.

  • Quantitative assessment of the nanoanatomy of the contractile vacuole complex in <em>Trypanosoma cruzi</em>
    Open Access
    Quantitative assessment of the nanoanatomy of the contractile vacuole complex in Trypanosoma cruzi

    Ingrid Augusto, Wendell Girard-Dias, Alejandra Schoijet, Guillermo Daniel Alonso, Rodrigo V Portugal, Wanderley de Souza, Veronica Jimenez, Kildare Miranda

    Ingrid Augusto ... Kildare Miranda

    Published 29 July 2024

    Electron microscopy analysis of the osmoregulatory system in T. cruzi cell lines subjected to cryopreparation methods revealed dynamic changes in the contractile vacuole complex (CVC) and the structure of the adhesion plaque domain during the CVC pulsation cycle.

  • FAT10 inhibits TRIM21 to down-regulate antiviral type-I interferon secretion
    Open Access
    FAT10 inhibits TRIM21 to down-regulate antiviral type-I interferon secretion

    Kritika Saxena, Katharina Inholz, Michael Basler, Annette Aichem

    Kritika Saxena ... Annette Aichem

    Published 8 July 2024

    The ubiquitin-like modifier FAT10 down-regulates the antiviral type-I IFN response not only by targeting OTUB1 but also by degrading the E3 TRIM21 and by inhibiting its activation upon IAV infection.

  • Open Access
    Correction: Reduced protein-coding transcript diversity in severe dengue emphasises the role of alternative splicing

    Priyanka Mehta, Chinky Shiu Chen Liu, Sristi Sinha, Ramakant Mohite, Smriti Arora, Partha Chattopadhyay, Sandeep Budhiraja, Bansidhar Tarai, Rajesh Pandey

    Priyanka Mehta ... Rajesh Pandey

    Published 14 June 2024

    Transcriptomic analysis of dengue-infected patients reveals altered immune response pathways, transcript diversity, and splicing efficiency, underscoring potential therapeutic targets for treatment.

  • Reduced protein-coding transcript diversity in severe dengue emphasises the role of alternative splicing
    Open Access
    Reduced protein-coding transcript diversity in severe dengue emphasises the role of alternative splicing

    Priyanka Mehta, Chinky Shiu Chen Liu, Sristi Sinha, Ramakant Mohite, Smriti Arora, Partha Chattopadhyay, Sandeep Budhiraja, Bansidhar Tarai, Rajesh Pandey

    Priyanka Mehta ... Rajesh Pandey

    Published 3 June 2024

    Transcriptomic analysis of dengue-infected patients reveals altered immune response pathways, transcript diversity, and splicing efficiency, underscoring potential therapeutic targets for treatment.

  • PrgE: an OB-fold protein from plasmid pCF10 with striking differences to prototypical bacterial SSBs
    Open Access
    PrgE: an OB-fold protein from plasmid pCF10 with striking differences to prototypical bacterial SSBs

    Annika Breidenstein, Anaïs Lamy, Cyrielle PJ Bader, Wei-Sheng Sun, Paulina H Wanrooij, Ronnie P-A Berntsson

    Annika Breidenstein ... Ronnie P-A Berntsson

    Published 29 May 2024

    Enterococcal PrgE, from the conjugative plasmid pCF10, is a non-typical SSB that not only binds ssDNA in a filamentous manner but also binds dsDNA equally well as ssDNA.

  • Dual neutrophil subsets exacerbate or suppress inflammation in tuberculosis via IL-1β or PD-L1
    Open Access
    Dual neutrophil subsets exacerbate or suppress inflammation in tuberculosis via IL-1β or PD-L1

    Emilie Doz-Deblauwe, Badreddine Bounab, Florence Carreras, Julia S Fahel, Sergio C Oliveira, Mohamed Lamkanfi, Yves Le Vern, Pierre Germon, Julien Pichon, Florent Kempf, Christophe Paget, Aude Remot, Nathalie Winter

    Emilie Doz-Deblauwe ... Nathalie Winter

    Published 21 May 2024

    Neutrophils, key cells in tuberculosis, reach the lungs as two distinct subsets playing opposite roles in inflammation: either exacerbating via IL-1b or dampening via PD-L1.

  • Full-length MSP1 is a major target of protective immunity after controlled human malaria infection
    Open Access
    Full-length MSP1 is a major target of protective immunity after controlled human malaria infection

    Micha Rosenkranz, Irene N Nkumama, Rodney Ogwang, Sara Kraker, Marie Blickling, Kennedy Mwai, Dennis Odera, James Tuju, Kristin Fürle, Roland Frank, Emily Chepsat, Melissa C Kapulu, CHMI-SIKA Study Team, Faith HA Osier

    Micha Rosenkranz ... Faith HA Osier

    Published 20 May 2024

    Full-length merozoite surface protein 1 is an important target of functional antibodies that play an important role in clinical immunity against invasive asexual Plasmodium falciparum parasites.

  • Modulating mycobacterial envelope integrity for antibiotic synergy with benzothiazoles
    Open Access
    Modulating mycobacterial envelope integrity for antibiotic synergy with benzothiazoles

    Eva Habjan, Alexander Lepioshkin, Vicky Charitou, Anna Egorova, Elena Kazakova, Vien QT Ho, Wilbert Bitter, Vadim Makarov, Alexander Speer

    Eva Habjan ... Alexander Speer

    Published 14 May 2024

    This study explores benzothiazoles targeting a novel mycobacterial vulnerability, resulting in increased mycobacterial cell envelope permeability and enhanced antibiotic activity.

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