Microbiology, Virology & Host Pathogen Interaction
The immune and microbial homeostasis determines the Candida–mast cells cross-talk in celiac diseaseThis study shows that the restoration of immune and microbial homeostasis promotes a beneficial Candida albicans–MC cross-talk attenuating the intestinal pathology in celiac disease.
Subdomains of the Helicobacter pylori Cag T4SS outer membrane core complex exhibit structural independenceStructural and proteomic analyses of H. pylori Cag T4SSs purified from deletion mutants highlight the unexpected structural independence between the OMC and PR, two major subdomains of this complex.
DEFA1A3 DNA gene-dosage regulates the kidney innate immune response during upper urinary tract infectionα-Defensin 1-3 (DEFA1A3) are host antimicrobial peptides with potent innate immune functions during infectious diseases. Differential UTI risk has been linked to DEFA1A3 DNA polymorphisms. This study elucidates mechanisms of DEFA1A3 gene dose–dependent protection against UTI pathogenesis.
Differential effects of translation inhibitors on Plasmodium berghei liver stage parasitesFive diverse translation inhibitors are tested at equivalent effective concentrations, revealing that translation inhibition efficacy does not determine the Plasmodium berghei liver stage antiplasmodial efficacy.
Genetic structure and diversity of the rfb locus of pathogenic species of the genus LeptospiraThis study provides a broad investigation of the gene composition of the rfb locus, the main genetic factor associated with serology in Leptospira, and opens the way for molecular diagnostics in leptospirosis.
Stable structures or PABP1 loading protects cellular and viral RNAs against ISG20-mediated decayIn this work, two novel elements that modulate the susceptibility of target RNAs to degradation by the antiviral RNase ISG20 are described.
Inflammatory markers for improved recurrent UTI diagnosis in postmenopausal womenHere, we identify urinary cytokines that are differentially abundant in postmenopausal women with symptomatic recurrent UTI compared with controls and evaluate their ability to accurately diagnose UTI.
Stability of gut microbiome after COVID-19 vaccination in healthy and immuno-compromised individualsThis study highlights the resilience of the gut microbiome to host immune changes triggered by COVID-19 vaccination and suggest minimal, if any, impact on microbiome-mediated processes.
Zebrafish tsc1 and cxcl12a increase susceptibility to mycobacterial infectionKnockdown of miR-126 increases susceptibility to mycobacterial infection which can be independently reversed by targeting Tsc1/mTOR or ccr2 implicating macrophage function.
Integrated analysis of RNA-seq datasets reveals novel targets and regulators of COVID-19 severityThis work observed differential expression of genes related to the endomembrane system, specific granules, T cell receptor complex, and SPI1 and TP53 target genes exclusively in severe COVID-19 patients.