Microbiology, Virology & Host Pathogen Interaction
ADAPTABLE: a comprehensive web platform of antimicrobial peptides tailored to the user’s researchADAPTABLE is a webserver and database of antimicrobial peptides that uses sequence and property alignment to highlight their mode of action against the threat of resistance in medicine and agriculture.
Pseudomonas aeruginosa lectin LecB impairs keratinocyte fitness by abrogating growth factor signallingThis study provides a novel function of the bacterial lectin LecB, which dampens cell proliferation and survival by targeting the insulin-like growth factor-1 for degradation, without receptor activation.
Thymosin β4 promotes autophagy and repair via HIF-1α stabilization in chronic granulomatous diseaseThis study demonstrates that thymosin β4 stabilizes HIF-1a to promote autophagy and up-regulate genes involved in tissue and mucosal barrier protection in chronic granulomatous disease.
Conservation of cell-intrinsic immune responses in diverse nonhuman primate speciesThe transcriptomic response of diverse nonhuman primate (NHP) species to poly(I:C) is highly conserved, and this novel RNA sequencing dataset will help improve NHP genome annotations.
XIAP controls RIPK2 signaling by preventing its deposition in speck-like structuresThis study provides evidence that the NOD1/2-associated kinase RIPK2 localizes to detergent insoluble cytosolic complexes upon activation and suggests novel regulatory mechanisms for RIPK2 signaling.
Assembly mechanisms of the bacterial cytoskeletal protein FilPFilP is a coiled-coil protein that self-assembles into striated filaments and meshwork that shares structural and biochemical characteristics with metazoan intermediate filaments.
Tamoxifen blocks retrograde trafficking of Shiga toxin 1 and 2 and protects against lethal toxicosisThis study reports an unexpected role of late endosome–lysosome fusion in early endosome-to-Golgi trafficking of Shiga toxins and identifies tamoxifen to be a potent inhibitor of Shiga toxicosis.
An unusual and vital protein with guanylate cyclase and P4-ATPase domains in a pathogenic protistToxoplasma gondii harbors an alveolate-specific guanylate cyclase linked to P-type ATPase motifs, which is an essential actuator of cGMP-dependent gliding motility, egress, and invasion during acute infection.
Evidence for vesicle-mediated antigen export by the human pathogen Babesia microtiThe human pathogen Babesia microti undergoes unique morphogenesis during its development within human and mouse red blood cells and uses a novel vesicle-based system for export of antigens into the host cell and environment.
PKAc is not required for the preerythrocytic stages of Plasmodium bergheiThe mutant salivary gland sporozoites lacking PKAc are able to glide, invade hepatocytes, and mature into hepatic merozoites, which release successfully from the merosome, however, fail to initiate blood stage infection when inoculated into mice.