Microbiology, Virology & Host Pathogen Interaction
Transmembrane protease serine 2 (TMPRSS2) rs75603675, comorbidity, and sex are the primary predictors of COVID-19 severityThe TMPRSS2 rs75603675 genotype (OR = 0.586), dyslipidemia (OR = 2.289), sex (OR = 0.586), and the Charlson Comorbidity Index (OR = 1.126) were identified as the main predictors of COVID-19 severity in 817 patients who attended Hospital Universitario de La Princesa during March and April 2020.
OXSR1 inhibits inflammasome activation by limiting potassium efflux during mycobacterial infectionMycobacteria up-regulate host kinase OXSR1 preventing potassium efflux and inflammasome activation. Depletion or inhibition of OXSR1 potentiates inflammasome activation and decreases bacterial burden.
Genome-scale metabolic models for natural and long-term drug-induced viral control in HIV infectionA system-level up-regulation of OXPHOS and glycolysis could play a role in latent reservoir dynamics and immunosenescence in HIV-1–infected individuals with long-term successful therapy.
Subgenomic RNA profiling suggests novel mechanism in coronavirus gene regulation and host adaptionCORONATATOR, developed to analyze the subgenomic RNA of coronavirus, was applied on large number of sequencing data sets from coronaviruses, and shed light on viral gene regulation.
A novel domain within the CIL regulates egress of IFITM3 from the Golgi and reveals a regulatory role of IFITM3 on the secretory pathwayIn this work, it is revealed that the broad viral inhibitor IFITM3 is a previously unrecognized modulator of the functionalities of the cellular ER–Golgi secretory pathway.
SARS-CoV-2 spike E156G/Δ157-158 mutations contribute to increased infectivity and immune escapeThis study underscores the significance of NTD-specific SARS-CoV-2 spike mutations E156G/Δ157-158 in determining virion infectivity and neutralization by vaccine-elicited antibodies.
Structure and conformational dynamics of Clostridioides difficile toxin AThis study presents a complete structural model of TcdA holotoxin and sheds new lights into the conformational dynamics of TcdA and its roles in TcdA intoxication.
Monobodies with potent neutralizing activity against SARS-CoV-2 Delta and other variants of concernBy extensive affinity maturation against the SARS-CoV-2 spike protein, we developed a monobody with potent neutralizing activity against SARS-CoV-2 B.1.1 and four other variants of concern.
Genome analysis of Legionella pneumophila ST23 from various countries reveals highly similar strainsST23 isolated in Italy are analysed by cgMLST and SNP approaches and they are also compared with ST23 from other countries. They are found to be phylogenetically related independently on year, town, or country of isolation.
Leishmania survives by exporting miR-146a from infected to resident cells to subjugate inflammationLeishmania donovani infects and hijacks microRNA import-export machinery of host macrophages and survives by communicating the host-derived miR-146a to neighbouring cells and stops inflammation.