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Microbiology, Virology & Host Pathogen Interaction

  • Transmembrane protease serine 2 (<em>TMPRSS2</em>) rs75603675, comorbidity, and sex are the primary predictors of COVID-19 severity
    Open Access
    Transmembrane protease serine 2 (TMPRSS2) rs75603675, comorbidity, and sex are the primary predictors of COVID-19 severity

    Gonzalo Villapalos-García, Pablo Zubiaur, Rebeca Rivas-Durán, Pilar Campos-Norte, Cristina Arévalo-Román, Marta Fernández-Rico, Lucio García-Fraile Fraile, Paula Fernández-Campos, Paula Soria-Chacartegui, Sara Fernández de Córdoba-Oñate, Pablo Delgado-Wicke, Elena Fernández-Ruiz, Isidoro González-Álvaro, Jesús Sanz, Francisco Abad-Santos, Ignacio de los Santos

    Gonzalo Villapalos-García ... Ignacio de los Santos

    Published 30 May 2022

    The TMPRSS2 rs75603675 genotype (OR = 0.586), dyslipidemia (OR = 2.289), sex (OR = 0.586), and the Charlson Comorbidity Index (OR = 1.126) were identified as the main predictors of COVID-19 severity in 817 patients who attended Hospital Universitario de La Princesa during March and April 2020.

  • OXSR1 inhibits inflammasome activation by limiting potassium efflux during mycobacterial infection
    Open Access
    OXSR1 inhibits inflammasome activation by limiting potassium efflux during mycobacterial infection

    Elinor Hortle, Vi LT Tran, Kathryn Wright, Angela RM Fontaine, Natalia Pinello, Matthew B O’Rourke, Justin J-L Wong, Philip M Hansbro, Warwick J Britton, Stefan H Oehlers

    Elinor Hortle ... Stefan H Oehlers

    Published 11 May 2022

    Mycobacteria up-regulate host kinase OXSR1 preventing potassium efflux and inflammasome activation. Depletion or inhibition of OXSR1 potentiates inflammasome activation and decreases bacterial burden.

  • Genome-scale metabolic models for natural and long-term drug-induced viral control in HIV infection
    Open Access
    Genome-scale metabolic models for natural and long-term drug-induced viral control in HIV infection

    Anoop T Ambikan, Sara Svensson-Akusjärvi, Shuba Krishnan, Maike Sperk, Piotr Nowak, Jan Vesterbacka, Anders Sönnerborg, Rui Benfeitas, Ujjwal Neogi

    Anoop T Ambikan ... Ujjwal Neogi

    Published 10 May 2022

    A system-level up-regulation of OXPHOS and glycolysis could play a role in latent reservoir dynamics and immunosenescence in HIV-1–infected individuals with long-term successful therapy.

  • Subgenomic RNA profiling suggests novel mechanism in coronavirus gene regulation and host adaption
    Open Access
    Subgenomic RNA profiling suggests novel mechanism in coronavirus gene regulation and host adaption

    Lin Lyu, Ru Feng, Mingnan Zhang, Xiaoqing Xie, Yinjing Liao, Yanjiao Zhou, Xiaokui Guo, Bing Su, Yair Dorsett, Lei Chen

    Lin Lyu ... Lei Chen

    Published 25 April 2022

    CORONATATOR, developed to analyze the subgenomic RNA of coronavirus, was applied on large number of sequencing data sets from coronaviruses, and shed light on viral gene regulation.

  • A novel domain within the CIL regulates egress of IFITM3 from the Golgi and reveals a regulatory role of IFITM3 on the secretory pathway
    Open Access
    A novel domain within the CIL regulates egress of IFITM3 from the Golgi and reveals a regulatory role of IFITM3 on the secretory pathway

    Li Zhong, Yuxin Song, Federico Marziali, Rustem Uzbekov, Xuan-Nhi Nguyen, Chloé Journo, Philippe Roingeard, Andrea Cimarelli

    Li Zhong ... Andrea Cimarelli

    Published 8 April 2022

    In this work, it is revealed that the broad viral inhibitor IFITM3 is a previously unrecognized modulator of the functionalities of the cellular ER–Golgi secretory pathway.

  • SARS-CoV-2 spike E156G/Δ157-158 mutations contribute to increased infectivity and immune escape
    Open Access
    SARS-CoV-2 spike E156G/Δ157-158 mutations contribute to increased infectivity and immune escape

    Tarun Mishra, Rishikesh Dalavi, Garima Joshi, Atul Kumar, Pankaj Pandey, Sanjeev Shukla, Ram K Mishra, Ajit Chande

    Tarun Mishra ... Ajit Chande

    Published 16 March 2022

    This study underscores the significance of NTD-specific SARS-CoV-2 spike mutations E156G/Δ157-158 in determining virion infectivity and neutralization by vaccine-elicited antibodies.

  • Structure and conformational dynamics of <em>Clostridioides difficile</em> toxin A
    Open Access
    Structure and conformational dynamics of Clostridioides difficile toxin A

    Baohua Chen, Sujit Basak, Peng Chen, Changcheng Zhang, Kay Perry, Songhai Tian, Clinton Yu, Min Dong, Lan Huang, Mark E Bowen, Rongsheng Jin

    Baohua Chen ... Rongsheng Jin

    Published 15 March 2022

    This study presents a complete structural model of TcdA holotoxin and sheds new lights into the conformational dynamics of TcdA and its roles in TcdA intoxication.

  • Monobodies with potent neutralizing activity against SARS-CoV-2 Delta and other variants of concern
    Open Access
    Monobodies with potent neutralizing activity against SARS-CoV-2 Delta and other variants of concern

    Taishi Kondo, Kazuhiro Matsuoka, Shun Umemoto, Tomoshige Fujino, Gosuke Hayashi, Yasumasa Iwatani, Hiroshi Murakami

    Taishi Kondo ... Hiroshi Murakami

    Published 7 March 2022

    By extensive affinity maturation against the SARS-CoV-2 spike protein, we developed a monobody with potent neutralizing activity against SARS-CoV-2 B.1.1 and four other variants of concern.

  • Genome analysis of <em>Legionella pneumophila</em> ST23 from various countries reveals highly similar strains
    Open Access
    Genome analysis of Legionella pneumophila ST23 from various countries reveals highly similar strains

    Maria Luisa Ricci, Silvia Fillo, Andrea Ciammaruconi, Florigio Lista, Christophe Ginevra, Sophie Jarraud, Antonietta Girolamo, Fabrizio Barbanti, Maria Cristina Rota, Diane Lindsay, Jamie Gorzynski, Søren A Uldum, Sharmin Baig, Marina Foti, Giancarlo Petralito, Stefania Torri, Marino Faccini, Maira Bonini, Gabriella Gentili, Sabrina Senatore, Anna Lamberti, Joao André Carrico, Maria Scaturro

    Maria Luisa Ricci ... Maria Scaturro

    Published 2 March 2022

    ST23 isolated in Italy are analysed by cgMLST and SNP approaches and they are also compared with ST23 from other countries. They are found to be phylogenetically related independently on year, town, or country of isolation.

  • Leishmania survives by exporting miR-146a from infected to resident cells to subjugate inflammation
    Open Access
    Leishmania survives by exporting miR-146a from infected to resident cells to subjugate inflammation

    Satarupa Ganguly, Bartika Ghoshal, Ishani Banerji, Shreya Bhattacharjee, Sreemoyee Chakraborty, Avijit Goswami, Kamalika Mukherjee, Suvendra N Bhattacharyya

    Satarupa Ganguly ... Suvendra N Bhattacharyya

    Published 24 February 2022

    Leishmania donovani infects and hijacks microRNA import-export machinery of host macrophages and survives by communicating the host-derived miR-146a to neighbouring cells and stops inflammation.

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