Metabolism
- TMBIM5 loss of function alters mitochondrial matrix ion homeostasis and causes a skeletal myopathy
TMBIM5 deficiency reduces mitochondrial K+/H+ exchange. Mutation of the channel pore in mice destabilizes the protein and results in increased embryonic lethality and a skeletal myopathy.
- The cation exchanger Letm1, circadian rhythms, and NAD(H) levels interconnect in diurnal zebrafish
The mitochondrial osmoregulator Letm1 exhibits a diel regulation, impacts on NAD+/H levels, circadian genes, and its study allows new perspectives on possible genetic compensation mechanisms.
- The HDL particle composition determines its antitumor activity in pancreatic cancer
The authors show that particle composition–dependent, efficient HDL-mediated cholesterol depletion induces apoptosis and interferes with the aggressive growth characteristics of pancreatic cancer cells.
- Genome-scale metabolic models for natural and long-term drug-induced viral control in HIV infection
A system-level up-regulation of OXPHOS and glycolysis could play a role in latent reservoir dynamics and immunosenescence in HIV-1–infected individuals with long-term successful therapy.
- Adipose tissue–specific ablation of Ces1d causes metabolic dysregulation in mice
Ces1d is a crucial enzyme in adipose tissue. Here, we found a high level of Ces1d translocates onto lipid droplets where it digests the lipids to produce unique fatty acids which are key for glucose and lipid metabolism.
- ESCRT-I fuels lysosomal degradation to restrict TFEB/TFE3 signaling via the Rag-mTORC1 pathway
ESCRT-I deficiency impairs lysosome membrane turnover and induces homeostatic responses to lysosomal nutrient starvation including activation of MiT-TFE signaling caused by inhibition of the substrate-specific mTORC1 pathway.
- Growth-rate-dependent and nutrient-specific gene expression resource allocation in fission yeast
During growth on nitrogen sources, growth-rate-correlated gene expression is a trade-off between the stress and growth programmes, whereas medium-specific gene expression reflects metabolic states.
- Obesity-induced senescent macrophages activate a fibrotic transcriptional program in adipocyte progenitors
This study demonstrates that senescent CD9+ macrophages in obese visceral fat of mice secrete osteopontin that promotes ECM deposition by adipogenic progenitor cells expressing Pdgfra and Pdgfrb.
- Cap analysis of gene expression reveals alternative promoter usage in a rat model of hypertension
Cap analysis of gene expression (CAGE) tag sequencing from left ventricles of a rat model of hypertension identifies genes that use alternative promoters in a disease condition.
- Necrotic debris and STING exert therapeutically relevant effects on tumor cholesterol homeostasis
Necrotic debris and STING affect tumor cell growth by altering cholesterol homeostasis in opposing manner, revealing that modulation of cellular cholesterol load may help control tumor growth.