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Metabolism

  • The cation exchanger Letm1, circadian rhythms, and NAD(H) levels interconnect in diurnal zebrafish
    Open Access
    The cation exchanger Letm1, circadian rhythms, and NAD(H) levels interconnect in diurnal zebrafish

    Pauline Dao, Stefan Hajny, Ronald Mekis, Lukas Orel, Nora Dinhopl, Kristin Tessmar-Raible, Karin Nowikovsky

    Pauline Dao ... Karin Nowikovsky

    Published 13 June 2022

    The mitochondrial osmoregulator Letm1 exhibits a diel regulation, impacts on NAD+/H levels, circadian genes, and its study allows new perspectives on possible genetic compensation mechanisms.

  • The HDL particle composition determines its antitumor activity in pancreatic cancer
    Open Access
    The HDL particle composition determines its antitumor activity in pancreatic cancer

    Raimund Oberle, Kristina Kührer, Tamina Österreicher, Florian Weber, Stefanie Steinbauer, Florian Udonta, Mark Wroblewski, Isabel Ben-Batalla, Ingrid Hassl, Jakob Körbelin, Matthias Unseld, Matti Jauhiainen, Birgit Plochberger, Clemens Röhrl, Markus Hengstschläger, Sonja Loges, Herbert Stangl

    Raimund Oberle ... Herbert Stangl

    Published 16 May 2022

    The authors show that particle composition–dependent, efficient HDL-mediated cholesterol depletion induces apoptosis and interferes with the aggressive growth characteristics of pancreatic cancer cells.

  • Genome-scale metabolic models for natural and long-term drug-induced viral control in HIV infection
    Open Access
    Genome-scale metabolic models for natural and long-term drug-induced viral control in HIV infection

    Anoop T Ambikan, Sara Svensson-Akusjärvi, Shuba Krishnan, Maike Sperk, Piotr Nowak, Jan Vesterbacka, Anders Sönnerborg, Rui Benfeitas, Ujjwal Neogi

    Anoop T Ambikan ... Ujjwal Neogi

    Published 10 May 2022

    A system-level up-regulation of OXPHOS and glycolysis could play a role in latent reservoir dynamics and immunosenescence in HIV-1–infected individuals with long-term successful therapy.

  • Adipose tissue–specific ablation of Ces1d causes metabolic dysregulation in mice
    Open Access
    Adipose tissue–specific ablation of Ces1d causes metabolic dysregulation in mice

    Gang Li, Xin Li, Li Yang, Shuyue Wang, Yulin Dai, Baharan Fekry, Lucas Veillon, Lin Tan, Rebecca Berdeaux, Kristin Eckel-Mahan, Philip L Lorenzi, Zhongming Zhao, Richard Lehner, Kai Sun

    Gang Li ... Kai Sun

    Published 22 April 2022

    Ces1d is a crucial enzyme in adipose tissue. Here, we found a high level of Ces1d translocates onto lipid droplets where it digests the lipids to produce unique fatty acids which are key for glucose and lipid metabolism.

  • ESCRT-I fuels lysosomal degradation to restrict TFEB/TFE3 signaling via the Rag-mTORC1 pathway
    Open Access
    ESCRT-I fuels lysosomal degradation to restrict TFEB/TFE3 signaling via the Rag-mTORC1 pathway

    Marta Wróbel, Jarosław Cendrowski, Ewelina Szymańska, Malwina Grębowicz-Maciukiewicz, Noga Budick-Harmelin, Matylda Macias, Aleksandra Szybińska, Michał Mazur, Krzysztof Kolmus, Krzysztof Goryca, Michalina Dąbrowska, Agnieszka Paziewska, Michał Mikula, Marta Miączyńska

    Marta Wróbel ... Marta Miączyńska

    Published 30 March 2022

    ESCRT-I deficiency impairs lysosome membrane turnover and induces homeostatic responses to lysosomal nutrient starvation including activation of MiT-TFE signaling caused by inhibition of the substrate-specific mTORC1 pathway.

  • Growth-rate-dependent and nutrient-specific gene expression resource allocation in fission yeast
    Open Access
    Growth-rate-dependent and nutrient-specific gene expression resource allocation in fission yeast

    Istvan T Kleijn, Amalia Martínez-Segura, François Bertaux, Malika Saint, Holger Kramer, Vahid Shahrezaei, Samuel Marguerat

    Istvan T Kleijn ... Samuel Marguerat

    Published 28 February 2022

    During growth on nitrogen sources, growth-rate-correlated gene expression is a trade-off between the stress and growth programmes, whereas medium-specific gene expression reflects metabolic states.

  • Obesity-induced senescent macrophages activate a fibrotic transcriptional program in adipocyte progenitors
    Open Access
    Obesity-induced senescent macrophages activate a fibrotic transcriptional program in adipocyte progenitors

    Nabil Rabhi, Kathleen Desevin, Anna C Belkina, Andrew Tilston-Lunel, Xaralabos Varelas, Matthew D Layne, Stephen R Farmer

    Nabil Rabhi ... Stephen R Farmer

    Published 18 February 2022

    This study demonstrates that senescent CD9+ macrophages in obese visceral fat of mice secrete osteopontin that promotes ECM deposition by adipogenic progenitor cells expressing Pdgfra and Pdgfrb.

  • Cap analysis of gene expression reveals alternative promoter usage in a rat model of hypertension
    Open Access
    Cap analysis of gene expression reveals alternative promoter usage in a rat model of hypertension

    Sonal Dahale, Jorge Ruiz-Orera, Jan Silhavy, Norbert Hübner, Sebastiaan van Heesch, Michal Pravenec, Santosh S Atanur

    Sonal Dahale ... Santosh S Atanur

    Published 7 January 2022

    Cap analysis of gene expression (CAGE) tag sequencing from left ventricles of a rat model of hypertension identifies genes that use alternative promoters in a disease condition.

  • Necrotic debris and STING exert therapeutically relevant effects on tumor cholesterol homeostasis
    Open Access
    Necrotic debris and STING exert therapeutically relevant effects on tumor cholesterol homeostasis

    Sampath Katakam, Santosh Anand, Patricia Martin, Nicolo Riggi, Ivan Stamenkovic

    Sampath Katakam ... Ivan Stamenkovic

    Published 4 January 2022

    Necrotic debris and STING affect tumor cell growth by altering cholesterol homeostasis in opposing manner, revealing that modulation of cellular cholesterol load may help control tumor growth.

  • Elevation in sphingolipid upon SARS-CoV-2 infection: possible implications for COVID-19 pathology
    Open Access
    Elevation in sphingolipid upon SARS-CoV-2 infection: possible implications for COVID-19 pathology

    Einat B Vitner, Roy Avraham, Boaz Politi, Sharon Melamed, Tomer Israely

    Einat B Vitner ... Tomer Israely

    Published 11 November 2021

    SARS-CoV-2 infection alters the levels of sphingolipids early post infection. This phenomenon is reflected by increased levels of sphingolipids, including gangliosides, in infected cells, as well as in serum in a SARS-CoV-2 murine model.

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