Metabolism
Quantification of cristae architecture reveals time-dependent characteristics of individual mitochondriaA novel, machine-learning approach to quantify cristae density and architecture in live-cell super-resolution imaging characterizes the ultrastructural parameters of individual mitochondria over time.
Snail augments fatty acid oxidation by suppression of mitochondrial ACC2 during cancer progressionThis study reports a mechanism of mitochondrial ATP generation whereby EMT-inducer Snail controls ACC2 abundance and subsequent fatty acid oxidation to support cancer survival under starvation conditions.
Importance of γ-secretase in the regulation of liver X receptor and cellular lipid metabolismInhibition of the Alzheimer associated γ-secretase impairs the regulation of cellular lipid droplet homeostasis.
Immunoglobulin expression in the endoplasmic reticulum shapes the metabolic fitness of B lymphocytesImmunoglobulins shape mitochondrial function by driving ER expansion, this form of metabolic control is independent of the role the immunoglobulins play as part of the antigen receptor on the cell surface.
Essential role of the Crk family-dosage in DiGeorge-like anomaly and metabolic homeostasisThis study presents evidence that CRK/CRKL and TBX1 may share pathways that participate in organogenesis affected in DiGeorge syndrome (22q11.2DS) via global control of gene expression and metabolism
Metabolic reprogramming of fibro/adipogenic progenitors facilitates muscle regenerationHigh-fat diet ameliorates muscle dystrophic phenotype by promoting the FAP-dependent myogenesis of satellite cells.
Refining the adipose progenitor cell landscape in healthy and obese visceral adipose tissue using single-cell gene expression profilingThis work dissects adipose progenitor cell (APC) heterogeneity in normal and obese adipose tissue using single-cell expression profiling. Novel APC subpopulations are identified and characterized.
Glycine cleavage system determines the fate of pluripotent stem cells via the regulation of senescence and epigenetic modificationsThe glycine cleavage system (GCS) is highly activated to promote stem cell pluripotency. The GCS catabolizes glycine to prevent methylglyoxal accumulation and to fuel H3K4me3 modification, promoting the expression of pluripotency genes.
Structural and functional characterization of the mitochondrial complex IV assembly factor Coa6The structures of the mitochondrial complex IV assembly factor Coa6 and a pathogenic mutant variant (W59CCoa6) are reported, providing molecular mechanisms for its mode of action and the loss-of-function mutation.
Ncl1-mediated metabolic rewiring critical during metabolic stressAccumulation of cysteine induces translational defects and metabolic rewiring that are abrogated by leucine in a transfer RNA (tRNA) methyltransferase NCL1-dependent manner in yeast.