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Metabolism

  • MAP4K3 inhibits Sirtuin-1 to repress the LKB1–AMPK pathway to promote amino acid-dependent activation of the mTORC1 complex
    Open Access
    MAP4K3 inhibits Sirtuin-1 to repress the LKB1–AMPK pathway to promote amino acid-dependent activation of the mTORC1 complex

    Mary Rose Branch, Cynthia L Hsu, Kohta Ohnishi, Wen-Chuan Shen, Elian Lee, Jill Meisenhelder, Brett Winborn, Bryce L Sopher, J Paul Taylor, Tony Hunter, Albert R La Spada

    Mary Rose Branch ... Albert R La Spada

    Published 23 May 2023

    Our results reveal the existence of a novel signaling pathway linking amino acid satiety with MAP4K3-dependent suppression of SIRT1 to inactivate the repressive LKB1–AMPK pathway and thereby potently activate the mTORC1 complex to dictate the metabolic disposition of the cell.

  • Cognitive decline in diabetic mice predisposed to Alzheimer’s disease is greater than in wild type
    Open Access
    Cognitive decline in diabetic mice predisposed to Alzheimer’s disease is greater than in wild type

    Marta Carús-Cadavieco, Inés Berenguer López, Alba Montoro Canelo, Miguel A Serrano-Lope, Sandra González-de la Fuente, Begoña Aguado, Alba Fernández-Rodrigo, Takaomi C Saido, Ana Frank García, César Venero, José A Esteban, Francesc Guix, Carlos G Dotti

    Marta Carús-Cadavieco ... Carlos G Dotti

    Published 14 April 2023

    This work proposes that T2DM is particularly harmful to brain function in individuals with a genetic predisposition to neurodegenerative pathology via, among others, γ-secretase inhibition.

  • Proteomic analysis reveals microvesicles containing NAMPT as mediators of radioresistance in glioma
    Open Access
    Proteomic analysis reveals microvesicles containing NAMPT as mediators of radioresistance in glioma

    Elena Panizza, Brandon D Regalado, Fangyu Wang, Ichiro Nakano, Nathaniel M Vacanti, Richard A Cerione, Marc A Antonyak

    Elena Panizza ... Marc A Antonyak

    Published 10 April 2023

    Glioma patients often relapse because of resistance to radiation therapy. The transfer of the metabolic enzyme NAMPT via microvesicles and the accompanying elevated levels of NAD are found to be a mechanism by which glioma cells become resistant to radiation.

  • An OMA1 redox site controls mitochondrial homeostasis, sarcoma growth, and immunogenicity
    Open Access
    An OMA1 redox site controls mitochondrial homeostasis, sarcoma growth, and immunogenicity

    Richard Miallot, Virginie Millet, Yann Groult, Angelika Modelska, Lydie Crescence, Sandrine Roulland, Sandrine Henri, Bernard Malissen, Nicolas Brouilly, Laurence Panicot-Dubois, Renaud Vincentelli, Gerlind Sulzenbacher, Pascal Finetti, Aurélie Dutour, Jean-Yves Blay, François Bertucci, Franck Galland, Philippe Naquet

    Richard Miallot ... Philippe Naquet

    Published 5 April 2023

    This work describes how a mutation affecting mitochondrial metabolism in a sarcoma model induces protective immunity against the tumor and how this result might be relevant for sarcoma patients.

  • A novel approach to measure complex V ATP hydrolysis in frozen cell lysates and tissue homogenates
    Open Access
    A novel approach to measure complex V ATP hydrolysis in frozen cell lysates and tissue homogenates

    Lucia Fernandez-del-Rio, Cristiane Benincá, Frankie Villalobos, Cynthia Shu, Linsey Stiles, Marc Liesa, Ajit S Divakaruni, Rebeca Acin-Perez, Orian S Shirihai

    Lucia Fernandez-del-Rio ... Orian S Shirihai

    Published 14 March 2023

    This novel method can be used in clinical samples to determine CV function in diseases, with the added benefit of being able to use frozen samples in a high-throughput manner and to explore ATP hydrolysis as a drug target for disease treatment.

  • Cardiac Plin5 interacts with SERCA2 and promotes calcium handling and cardiomyocyte contractility
    Open Access
    Cardiac Plin5 interacts with SERCA2 and promotes calcium handling and cardiomyocyte contractility

    Mathieu Cinato, Ismena Mardani, Azra Miljanovic, Christina Drevinge, Marion Laudette, Entela Bollano, Marcus Henricsson, Johan Tolö, Marcos Bauza Thorbrügge, Max Levin, Malin Lindbom, Muhammad Arif, Pal Pacher, Linda Andersson, Charlotta S Olofsson, Jan Borén, Malin C Levin

    Mathieu Cinato ... Malin C Levin

    Published 30 January 2023

    We show that elevated cardiac Plin5 correlates with up-regulation of cardiac contraction–related processes, unraveling a novel Plin5 interaction with SERCA2 associated with improved calcium handling.

  • ZBTB18 inhibits SREBP-dependent lipid synthesis by halting CTBPs and LSD1 activity in glioblastoma
    Open Access
    ZBTB18 inhibits SREBP-dependent lipid synthesis by halting CTBPs and LSD1 activity in glioblastoma

    Roberto Ferrarese, Annalisa Izzo, Geoffroy Andrieux, Simon Lagies, Johanna Paulina Bartmuss, Anie Priscilla Masilamani, Alix Wasilenko, Daniela Osti, Stefania Faletti, Rana Schulzki, Shuai Yuan, Eva Kling, Valentino Ribecco, Dieter Henrik Heiland, Stefan Tholen, Marco Prinz, Giuliana Pelicci, Bernd Kammerer, Melanie Boerries, Maria Stella Carro

    Roberto Ferrarese ... Maria Stella Carro

    Published 22 November 2022

    This study identifies a new mechanism of fatty acid synthesis regulation in glioblastoma that involves ZBTB18, CTBP, and LSD1. The transcriptional repressor ZBTB18 interacts with CTBP and inhibits LSD1 demethylase activity.

  • Hepatic DKK1-driven steatosis is CD36 dependent
    Open Access
    Hepatic DKK1-driven steatosis is CD36 dependent

    Zhen Yang, Xinping Huang, Jiaye Zhang, Kai You, Yue Xiong, Ji Fang, Anteneh Getachew, Ziqi Cheng, Xiaorui Yu, Yan Wang, Feima Wu, Ning Wang, Shufen Feng, Xianhua Lin, Fan Yang, Yan Chen, Hongcheng Wei, Yin-xiong Li

    Zhen Yang ... Yin-xiong Li

    Published 21 November 2022

    Increased DKK1 in hepatic steatosis contributes CD36-mediated fatty acid uptake and insulin resistance.

  • Palmitate impairs circadian transcriptomics in muscle cells through histone modification of enhancers
    Open Access
    Palmitate impairs circadian transcriptomics in muscle cells through histone modification of enhancers

    Nicolas J Pillon, Laura Sardón Puig, Ali Altıntaş, Prasad G Kamble, Salvador Casaní-Galdón, Brendan M Gabriel, Romain Barrès, Ana Conesa, Alexander V Chibalin, Erik Näslund, Anna Krook, Juleen R Zierath

    Nicolas J Pillon ... Juleen R Zierath

    Published 27 October 2022

    The disruption of circadian rhythms because of lipid overload may lead to epigenomic changes that influence metabolism. Thus, a dietary or therapeutic modulation of lipid levels, a cornerstone in the treatment of metabolic disorders, may prevent circadian misalignment in peripheral tissues.

  • A high-content endogenous GLUT4 trafficking assay reveals new aspects of adipocyte biology
    Open Access
    A high-content endogenous GLUT4 trafficking assay reveals new aspects of adipocyte biology

    Alexis Diaz-Vegas, Dougall M Norris, Sigrid Jall-Rogg, Kristen C Cooke, Olivia J Conway, Amber S Shun-Shion, Xiaowen Duan, Meg Potter, Julian van Gerwen, Harry JM Baird, Sean J Humphrey, David E James, Daniel J Fazakerley, James G Burchfield

    Alexis Diaz-Vegas ... James G Burchfield

    Published 25 October 2022

    The authors describe a high-throughput method for measuring endogenous GLUT4 and transferrin receptor translocation in adipocytes. They reveal that this method has advantages over studying GLUT4 trafficking using overexpressed GLUT4 reporters, which are commonly used in the field.

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