Metabolism
High levels of TFAM repress mammalian mitochondrial DNA transcription in vivoThe TFAM-to-mtDNA ratio is critically important and must be maintained within a physiological range to allow normal mtDNA expression and prevent nucleoid hypercompaction in different mouse tissues.
Elevated glucose increases genomic instability by inhibiting nucleotide excision repairExposure to chronic, elevated glucose inhibits nucleotide excision repair, which leads to accumulation of DNA glycation adducts, increased DNA strand breaks, and activation of the DNA damage response.
RNA sequencing reveals niche gene expression effects of beta-hydroxybutyrate in primary myotubesRNA sequencing reveals primary myocyte-specific gene-regulatory niche effects for β-hydroxybutyrate but do not support a general signaling of β-hydroxybutyrate role in other primary cells or during cellular differentiation in vitro.
A phosphoproteomic approach reveals that PKD3 controls PKA-mediated glucose and tyrosine metabolismProtein kinase D3 (PKD3) regulates hepatic metabolism in a PKA-dependent manner and reveals many other putative PKD3 targets in the liver.
HCV poly U/UC sequence–induced inflammation leads to metabolic disorders in vulvar lichen sclerosisMulti-omics analysis reveals the elevation of HCV poly U/UC sequences, which induces abnormal inflammation and related metabolic disorder in vulvar lichen sclerosis.
Multifaceted regulation of hepatic lipid metabolism by YY1This study shows that YY1 regulates hepatic lipid metabolism by directly or indirectly regulating the expression of several key upstream transcription factors and their coactivators.
Mitochondrial Aurora kinase A induces mitophagy by interacting with MAP1LC3 and Prohibitin 2The multifunctional Ser/Thr kinase AURKA uses the Inner Mitochondrial Membrane receptor PHB2 and MAP1LC3 as a signalling platform to orchestrate the elimination of dysfunctional mitochondria.
Cancer-associated cells release citrate to support tumour metastatic progressionCancer-associated stroma is recruited by cancer cells to synthesise and release citrate necessary to support metastatic progression of the disease.
Lipocalin 13 enhances insulin secretion but is dispensable for systemic metabolic controlThorough preclinical evaluation reveals a negligible role of lipocalin 13 in systemic glucose and lipid metabolism.
Structural comparison of GLUT1 to GLUT3 reveal transport regulation mechanism in sugar porter familyA new structure of GLUT1, compared with GLUT3, can explain substrate affinity differences, and provide a functional rationale for key structural motifs that define the universal Sugar Porter family.