Metabolism
- Correction: The pyruvate dehydrogenase complex regulates mitophagic trafficking and protein phosphorylation
Mutations in the PDC affect the phosphorylation and mitophagic trafficking of matrix proteins, through the novel regulation of associated kinases and a phosphatase. We suggest that this occurs by the direct allosteric regulation of the phosphatase and kinases by the PDC.
- Starvation-resistant cavefish reveal conserved mechanisms of starvation-induced hepatic lipotoxicity
Cavefish evolved protection from starvation-induced liver damage through a reduction in fatty acid uptake regulated by FATP2, a mechanism conserved through 400 million years of animal evolution.
- Altered myocardial lipid regulation in junctophilin-2–associated familial cardiomyopathies
Our studies revealed, for the first time, unique alterations in the cardiac lipid composition—including distinct increases in neutral lipids and decreases in polar membrane lipids—in mice with HCM and DCM were caused by distinct JPH2 variants.
- Metabolic and circadian inputs encode anticipatory biogenesis of hepatic fed microRNAs
Unravelling molecular and physiological mechanisms that couple circadian and metabolic cues to regulate anticipatory miR biogenesis during fed-fast-refed cycles in the liver.
- Oxidative phosphorylation is a pivotal therapeutic target of fibrodysplasia ossificans progressiva
Oxidative phosphorylation plays a pivotal role in heterotopic ossification associated with fibrodysplasia ossificans progressiva, underscoring its potential as a significant therapeutic target.
- CLN3 deficiency leads to neurological and metabolic perturbations during early development
Cln3 CRISPR mutant zebrafish larvae display BMP depletion and accumulation of glycerophosphodiesters and cholesteryl esters at very early developmental stages, recapitulating key features of human CLN3 disease.
- tRF-1:30-Gly-CCC-3 inhibits thyroid cancer via binding to PC and modulating metabolic reprogramming
This study reports a mechanism of tRNA fragments in PTC whereby tRF-30 controls PC abundance and subsequent TCA cycle anaplerosis to affect metabolic reprogramming and cancer progression.
- 2-Hydroxyglutarate modulates histone methylation at specific loci and alters gene expression via Rph1 inhibition
This study investigates the genome-wide effects of 2-HG accumulation on chromatin and gene expression and identifies Rph1-dependent and H3K36me3-associated gene repression at silenced loci in yeast.
- ESYT1 tethers the ER to mitochondria and is required for mitochondrial lipid and calcium homeostasis
A protein complex composed of the outer mitochondrial membrane protein SYNJ2BP and the endoplasmic reticulum protein ESYT1 tethers the two organelles to facilitate calcium and lipid transfer.
- Performance and robustness analysis reveals phenotypic trade-offs in yeast
This study combines phenotypic data from yeast cultivations with quantification of robustness over a defined perturbation space, revealing trade-offs between performance and robustness.