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Metabolism

  • Lipocalin 13 enhances insulin secretion but is dispensable for systemic metabolic control
    Open Access
    Lipocalin 13 enhances insulin secretion but is dispensable for systemic metabolic control

    Lea Bühler, Adriano Maida, Elena Sophie Vogl, Anastasia Georgiadi, Andrea Takacs, Oliver Kluth, Annette Schürmann, Annette Feuchtinger, Christine von Toerne, Foivos-Filippos Tsokanos, Katarina Klepac, Gretchen Wolff, Minako Sakurai, Bilgen Ekim Üstünel, Peter Nawroth, Stephan Herzig

    Lea Bühler ... Stephan Herzig

    Published 3 February 2021

    Thorough preclinical evaluation reveals a negligible role of lipocalin 13 in systemic glucose and lipid metabolism.

  • Structural comparison of GLUT1 to GLUT3 reveal transport regulation mechanism in sugar porter family
    Open Access
    Structural comparison of GLUT1 to GLUT3 reveal transport regulation mechanism in sugar porter family

    Tânia Filipa Custódio, Peter Aasted Paulsen, Kelly May Frain, Bjørn Panyella Pedersen

    Tânia Filipa Custódio ... Bjørn Panyella Pedersen

    Published 3 February 2021

    A new structure of GLUT1, compared with GLUT3, can explain substrate affinity differences, and provide a functional rationale for key structural motifs that define the universal Sugar Porter family.

  • Degradation of arouser by endosomal microautophagy is essential for adaptation to starvation in <em>Drosophila</em>
    Open Access
    Degradation of arouser by endosomal microautophagy is essential for adaptation to starvation in Drosophila

    Anne-Claire Jacomin, Raksha Gohel, Zunoon Hussain, Agnes Varga, Tamas Maruzs, Mark Eddison, Margaux Sica, Ashish Jain, Kevin G Moffat, Terje Johansen, Andreas Jenny, Gabor Juhasz, Ioannis P Nezis

    Anne-Claire Jacomin ... Ioannis P Nezis

    Published 14 December 2020

    Drosophila EPS8-family protein Arouser is constitutively degraded by endosomal microautophagy; its stabilisation upon starvation is essential to the animal adaptation and survival.

  • Identification and characterization of distinct brown adipocyte subtypes in C57BL/6J mice
    Open Access
    Identification and characterization of distinct brown adipocyte subtypes in C57BL/6J mice

    Ruth Karlina, Dominik Lutter, Viktorian Miok, David Fischer, Irem Altun, Theresa Schöttl, Kenji Schorpp, Andreas Israel, Cheryl Cero, James W Johnson, Ingrid Kapser-Fischer, Anika Böttcher, Susanne Keipert, Annette Feuchtinger, Elisabeth Graf, Tim Strom, Axel Walch, Heiko Lickert, Thomas Walzthoeni, Matthias Heinig, Fabian J Theis, Cristina García-Cáceres, Aaron M Cypess, Siegfried Ussar

    Ruth Karlina ... Siegfried Ussar

    Published 30 November 2020

    Using a number of cell biological and statistical methods we identify and characterize EIF5, TCF25 and BIN1 as markers for individual brown adipocyte subtypes in C57BL/6J mice.

  • Inhibiting the reproduction of SARS-CoV-2 through perturbations in human lung cell metabolic network
    Open Access
    Inhibiting the reproduction of SARS-CoV-2 through perturbations in human lung cell metabolic network

    Hadrien Delattre, Kalesh Sasidharan, Orkun S Soyer

    Hadrien Delattre ... Orkun S Soyer

    Published 24 November 2020

    Using genomic and structural information from SARS-CoV-2, we created a biomass function capturing its amino and nucleic acid requirements and incorporated this into a metabolic model of the human lung cell to predict metabolic perturbations that inhibit virus reproduction.

  • MIC26 and MIC27 cooperate to regulate cardiolipin levels and the landscape of OXPHOS complexes
    Open Access
    MIC26 and MIC27 cooperate to regulate cardiolipin levels and the landscape of OXPHOS complexes

    Ruchika Anand, Arun Kumar Kondadi, Jana Meisterknecht, Mathias Golombek, Oliver Nortmann, Julia Riedel, Leon Peifer-Weiß, Nahal Brocke-Ahmadinejad, David Schlütermann, Björn Stork, Thomas O Eichmann, Ilka Wittig, Andreas S Reichert

    Ruchika Anand ... Andreas S Reichert

    Published 11 August 2020

    Apolipoproteins of MICOS, MIC26 and MIC27, cooperatively manage cristae structure, cardiolipin levels, and the global stability and integrity of respiratory chain supercomplexes and F1Fo–ATP synthase.

  • Mitochondrial spongiotic brain disease: astrocytic stress and harmful rapamycin and ketosis effect
    Open Access
    Mitochondrial spongiotic brain disease: astrocytic stress and harmful rapamycin and ketosis effect

    Olesia Ignatenko, Joni Nikkanen, Alexander Kononov, Nicola Zamboni, Gulayse Ince-Dunn, Anu Suomalainen

    Olesia Ignatenko ... Anu Suomalainen

    Published 31 July 2020

    Astrocyte-specific mtDNA depletion causes spongiotic encephalopathy, aggravated by ketogenic diet or rapamycin. Astrocytes, but not neurons, drive mitochondrial integrated stress response in the CNS.

  • BH4 activates CaMKK2 and rescues the cardiomyopathic phenotype in rodent models of diabetes
    Open Access
    BH4 activates CaMKK2 and rescues the cardiomyopathic phenotype in rodent models of diabetes

    Hyoung Kyu Kim, Tae Hee Ko, In-Sung Song, Yu Jeong Jeong, Hye Jin Heo, Seung Hun Jeong, Min Kim, Nam Mi Park, Dae Yun Seo, Pham Trong Kha, Sun-Woo Kim, Sung Ryul Lee, Sung Woo Cho, Jong Chul Won, Jae Boum Youm, Kyung Soo Ko, Byoung Doo Rhee, Nari Kim, Kyoung Im Cho, Ippei Shimizu, Tohru Minamino, Nam-Chul Ha, Young Shik Park, Bernd Nilius, Jin Han

    Hyoung Kyu Kim ... Jin Han

    Published 22 July 2020

    This study reports that BH4 activates CaMKK2/PGC-1α; signaling pathway and has a therapeutic effect on diabetic cardiomyopathy.

  • Quantification of cristae architecture reveals time-dependent characteristics of individual mitochondria
    Open Access
    Quantification of cristae architecture reveals time-dependent characteristics of individual mitochondria

    Mayuko Segawa, Dane M Wolf, Nan W Hultgren, David S Williams, Alexander M van der Bliek, David B Shackelford, Marc Liesa, Orian S Shirihai

    Mayuko Segawa ... Orian S Shirihai

    Published 4 June 2020

    A novel, machine-learning approach to quantify cristae density and architecture in live-cell super-resolution imaging characterizes the ultrastructural parameters of individual mitochondria over time.

  • Snail augments fatty acid oxidation by suppression of mitochondrial ACC2 during cancer progression
    Open Access
    Snail augments fatty acid oxidation by suppression of mitochondrial ACC2 during cancer progression

    Ji Hye Yang, Nam Hee Kim, Jun Seop Yun, Eunae Sandra Cho, Yong Hoon Cha, Sue Bean Cho, Seon-Hyeong Lee, So Young Cha, Soo-Youl Kim, Jiwon Choi, Tin-Tin Manh Nguyen, Sunghyouk Park, Hyun Sil Kim, Jong In Yook

    Ji Hye Yang ... Jong In Yook

    Published 2 June 2020

    This study reports a mechanism of mitochondrial ATP generation whereby EMT-inducer Snail controls ACC2 abundance and subsequent fatty acid oxidation to support cancer survival under starvation conditions.

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