Metabolism
2-Hydroxyglutarate modulates histone methylation at specific loci and alters gene expression via Rph1 inhibitionThis study investigates the genome-wide effects of 2-HG accumulation on chromatin and gene expression and identifies Rph1-dependent and H3K36me3-associated gene repression at silenced loci in yeast.
ESYT1 tethers the ER to mitochondria and is required for mitochondrial lipid and calcium homeostasisA protein complex composed of the outer mitochondrial membrane protein SYNJ2BP and the endoplasmic reticulum protein ESYT1 tethers the two organelles to facilitate calcium and lipid transfer.
Performance and robustness analysis reveals phenotypic trade-offs in yeastThis study combines phenotypic data from yeast cultivations with quantification of robustness over a defined perturbation space, revealing trade-offs between performance and robustness.
Activation of the JNK/COX-2/HIF-1α axis promotes M1 macrophage via glycolytic shift in HIV-1 infectionThis study reveals JNK/COX-2/HIF-1α axis activation enhances glycolysis, promoting M1 polarization in HIV-1–infected macrophages, offering a novel approach to AIDS-related inflammation.
Mitochondrial membrane potential acts as a retrograde signal to regulate cell cycle progressionThis study finds that decreases in mitochondrial membrane potential serve as a means of mito-cellular signalling to delay the transition of yeast cells from the G1 to the S phase of the cell cycle.
Huntingtin loss in hepatocytes is associated with altered metabolism, adhesion, and liver zonationLifelong huntingtin loss in mouse hepatocytes is associated with altered metabolism, adhesion, and liver zonation which mimics the phenotypes caused by impaired B-catenin function.
Loss of the mitochondrial protein SPD-3 elevates PLK-1 levels and dysregulates mitotic eventsIn C. elegans a mutation in the mitochondria-localized protein SPD-3 leads to elevated levels of Polo-like kinase 1, causing abnormal chromosome positioning during mitosis.
Comprehensive analysis of the lysine succinylome in fish oil-treated prostate cancer cellsThrough a global lysine succinylation analysis of prostate cancer cells treated with fish oil, a significant number of lysine succinylation sites have been identified and FO-dependent GOT2 succinylation status may have a potential to inhibit building block generation.
T cell differentiation drives the negative selection of pathogenic mitochondrial DNA variantsFluorescently activated cell-sorting coupled with high-throughput single cell mtDNA sequencing reveals enhanced negative selection of pathogenic mtDNA variants in T cells, with more mature, memory cells exhibiting lower mutation levels than their naïve counterparts.
Decoding the obesity–cancer connection: lessons from preclinical models of pancreatic adenocarcinomaPreclinical models demonstrate that obesity reprograms the pretumor or tumor cell and its micro- and macro-environments to drive cancer development via altered cellular metabolism, hormone dysregulation, inflammation, and microbial dysbiosis.