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Medical Research

  • Loss of HDAC11 ameliorates clinical symptoms in a multiple sclerosis mouse model
    Open Access
    Loss of HDAC11 ameliorates clinical symptoms in a multiple sclerosis mouse model

    Lei Sun, Elphine Telles, Molly Karl, Fengdong Cheng, Noreen Luetteke, Eduardo M Sotomayor, Robert H Miller, Edward Seto

    Lei Sun ... Edward Seto

    Published 24 September 2018

    In an animal model for multiple sclerosis, the absence of HDAC11 reduces clinical severity, spinal cord demyelination, and immune cell infiltration, suggesting that HDAC11 is a promising target for MS treatment.

  • Identification of <em>Plasmodium</em> GAPDH epitopes for generation of antibodies that inhibit malaria infection
    Open Access
    Identification of Plasmodium GAPDH epitopes for generation of antibodies that inhibit malaria infection

    Sung-Jae Cha, Kyle Jarrod McLean, Marcelo Jacobs-Lorena

    Sung-Jae Cha ... Marcelo Jacobs-Lorena

    Published 18 September 2018

    This study reports on the identification of two Plasmodium GAPDH epitope peptides that are responsible for sporozoite–Kupffer cell interaction and act as antigens against malaria infection.

  • Discovery of a cofactor-independent inhibitor of <em>Mycobacterium tuberculosis</em> InhA
    Open Access
    Discovery of a cofactor-independent inhibitor of Mycobacterium tuberculosis InhA

    Yi Xia, Yasheen Zhou, David S Carter, Matthew B McNeil, Wai Choi, Jason Halladay, Pamela W Berry, Weimin Mao, Vincent Hernandez, Theresa O'Malley, Aaron Korkegian, Bjorn Sunde, Lindsay Flint, Lisa K Woolhiser, Michael S Scherman, Veronica Gruppo, Courtney Hastings, Gregory T Robertson, Thomas R Ioerger, Jim Sacchettini, Peter J Tonge, Anne J Lenaerts, Tanya Parish, MRK Alley

    Yi Xia ... MRK Alley

    Published 1 June 2018

    AN12855 is a novel cofactor-independent inhibitor of Mycobacterium tuberculosis InhA. AN12855 has potent activity against M. tuberculosis, good oral bioavailability, and comparable efficacy to isoniazid in infection models.

  • Multi-region proteome analysis quantifies spatial heterogeneity of prostate tissue biomarkers
    Open Access
    Multi-region proteome analysis quantifies spatial heterogeneity of prostate tissue biomarkers

    Tiannan Guo, Li Li, Qing Zhong, Niels J Rupp, Konstantina Charmpi, Christine E Wong, Ulrich Wagner, Jan H Rueschoff, Wolfram Jochum, Christian Daniel Fankhauser, Karim Saba, Cedric Poyet, Peter J Wild, Ruedi Aebersold, Andreas Beyer

    Tiannan Guo ... Andreas Beyer

    Published 29 May 2018

    Application of pressure cycling technology and Sequential Windowed Acquisition of all THeoretical mass spectrometry allows quantifying the degree of intra-tumor heterogeneity of protein expression in prostate tumors. The data show that protein intra-tumor heterogeneity, if not characterized, may distort protein biomarker suitability in tumor tissues.

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