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Medical Research

  • β-arrestin1 promotes tauopathy by transducing GPCR signaling, disrupting microtubules and autophagy
    Open Access
    β-arrestin1 promotes tauopathy by transducing GPCR signaling, disrupting microtubules and autophagy

    Jung-AA Woo, Yan Yan, Teresa R Kee, Sara Cazzaro, Kyle C McGill Percy, Xinming Wang, Tian Liu, Stephen B Liggett, David E Kang

    Jung-AA Woo ... David E Kang

    Published 3 December 2021

    GPCRs regulator, β-arrestin1, is increased in FTLD-tau patients, is required for β2-adrenergic receptor and metabotropic glutamate receptor 2-induced tau phosphorylation, promotes tau aggregation by impairing autophagy, and destabilizes microtubule dynamics, whereas genetic reduction in β-arrestin1 mitigates tauopathy and cognitive impairments.

  • Bis-choline tetrathiomolybdate prevents copper-induced blood–brain barrier damage
    Open Access
    Bis-choline tetrathiomolybdate prevents copper-induced blood–brain barrier damage

    Sabine Borchard, Stefanie Raschke, Krzysztof M Zak, Carola Eberhagen, Claudia Einer, Elisabeth Weber, Sandra M Müller, Bernhard Michalke, Josef Lichtmannegger, Albrecht Wieser, Tamara Rieder, Grzegorz M Popowicz, Jerzy Adamski, Martin Klingenspor, Andrew H Coles, Ruth Viana, Mikkel H Vendelbo, Thomas D Sandahl, Tanja Schwerdtle, Thomas Plitz, Hans Zischka

    Sabine Borchard ... Hans Zischka

    Published 2 December 2021

    The blood–brain barrier endothelial cell monolayer becomes permeable to elevated copper loosely bound to albumin, which can be avoided by a high-affinity copper chelator but not by D-penicillamine.

  • Transcriptomics reveals immune-metabolism disorder in acute-on-chronic liver failure in rats
    Open Access
    Transcriptomics reveals immune-metabolism disorder in acute-on-chronic liver failure in rats

    Hozeifa M Hassan, Qun Cai, Xi Liang, Jiaojiao Xin, Keke Ren, Jing Jiang, Dongyan Shi, Yingyan Lu, Tan Li, Yuxin Shang, Lulu He, Xi Chen, Suwan Sun, Peng Li, Beibei Guo, Jiaxian Chen, Hui Yang, Wen Hu, Xin Chen, Jun Li

    Hozeifa M Hassan ... Jun Li

    Published 1 December 2021

    Liver tissue transcriptomics of liver cirrhosis (LC)–based acute-on-chronic liver failure (ACLF) rats reveal immune-metabolism disorder as the core mechanism underlying ACLF development and prognosis.

  • Fundamentals of vaping-associated pulmonary injury leading to severe respiratory distress
    Open Access
    Fundamentals of vaping-associated pulmonary injury leading to severe respiratory distress

    Carolina Esquer, Oscar Echeagaray, Fareheh Firouzi, Clarissa Savko, Grant Shain, Pria Bose, Abigail Rieder, Sophie Rokaw, Andrea Witon-Paulo, Natalie Gude, Mark A Sussman

    Carolina Esquer ... Mark A Sussman

    Published 22 November 2021

    Vaping promotes pathological structural remodeling and functional impairment of the cardiopulmonary system in a mouse inhalation model. This model of vaping-associated pulmonary injury (VAPI) demonstrates potential health risks and provides mechanistic insights on cellular and molecular levels.

  • Bimodal fibrosis in a novel mouse model of bleomycin-induced usual interstitial pneumonia
    Open Access
    Bimodal fibrosis in a novel mouse model of bleomycin-induced usual interstitial pneumonia

    Yoko Miura, Maggie Lam, Jane E Bourke, Satoshi Kanazawa

    Yoko Miura ... Satoshi Kanazawa

    Published 2 November 2021

    A novel mouse model of induced-usual interstitial pneumonia shows bimodal fibrosis with honeycombing, similar to chronic lung disease seen with idiopathic pulmonary fibrosis.

  • Single-domain antibody screening by <em>is</em>PLA-seq
    Open Access
    Single-domain antibody screening by isPLA-seq

    Yueyuan Yin, Fei Yan, Ruimin Zhou, Mingchen Li, Jinyi Ma, Zhe Liu, Zhenyi Ma

    Yueyuan Yin ... Zhenyi Ma

    Published 21 October 2021

    This study describes a high-sensitive, high-throughput single-domain antibody library screening approach, which is applicable for any given interested protein at single-cell resolution by isPLA-seq.

  • Autoimmune anti-DNA and anti-phosphatidylserine antibodies predict development of severe COVID-19
    Open Access
    Autoimmune anti-DNA and anti-phosphatidylserine antibodies predict development of severe COVID-19

    Claudia Gomes, Marisol Zuniga, Kelly A Crotty, Kun Qian, Nubia Catalina Tovar, Lawrence Hsu Lin, Kimon V Argyropoulos, Robert Clancy, Peter Izmirly, Jill Buyon, David C Lee, Maria Fernanda Yasnot-Acosta, Huilin Li, Paolo Cotzia, Ana Rodriguez

    Claudia Gomes ... Ana Rodriguez

    Published 9 September 2021

    COVID-19 induces high levels of autoimmune anti-DNA and anti-phosphatidylserine antibodies that are detected in some patients upon hospital admission and predict later development of severe disease.

  • Serum proteomics reveals disorder of lipoprotein metabolism in sepsis
    Open Access
    Serum proteomics reveals disorder of lipoprotein metabolism in sepsis

    Xi Liang, Tianzhou Wu, Qi Chen, Jing Jiang, Yongpo Jiang, Yanyun Ruan, Huaping Zhang, Sheng Zhang, Chao Zhang, Peng Chen, Yuhang Lv, Jiaojiao Xin, Dongyan Shi, Xin Chen, Jun Li, Yinghe Xu

    Xi Liang ... Yinghe Xu

    Published 24 August 2021

    This study illustrated that lipoprotein and lipid metabolism might play a significant role in patients with sepsis and that complement activation was significantly enriched in patients with sepsis-associated encephalopathy.

  • Improved systemic AAV gene therapy with a neurotrophic capsid in Niemann–Pick disease type C1 mice
    Open Access
    Improved systemic AAV gene therapy with a neurotrophic capsid in Niemann–Pick disease type C1 mice

    Cristin D Davidson, Alana L Gibson, Tansy Gu, Laura L Baxter, Benjamin E Deverman, Keith Beadle, Arturo A Incao, Jorge L Rodriguez-Gil, Hideji Fujiwara, Xuntian Jiang, Randy J Chandler, Daniel S Ory, Viviana Gradinaru, Charles P Venditti, William J Pavan

    Cristin D Davidson ... William J Pavan

    Published 18 August 2021

    This work highlights the importance of CNS transduction for treatment of neurological diseases, a finding with significant clinical implications considering the long-lasting effects of gene therapy.

  • Negative correlation of single-cell <em>PAX3:FOXO1</em> expression with tumorigenicity in rhabdomyosarcoma
    Open Access
    Negative correlation of single-cell PAX3:FOXO1 expression with tumorigenicity in rhabdomyosarcoma

    Carla Regina, Ebrahem Hamed, Geoffroy Andrieux, Sina Angenendt, Michaela Schneider, Manching Ku, Marie Follo, Marco Wachtel, Eugene Ke, Ken Kikuchi, Anton G Henssen, Beat W Schäfer, Melanie Boerries, Amy J Wagers, Charles Keller, Simone Hettmer

    Carla Regina ... Simone Hettmer

    Published 29 June 2021

    Single-cell PAX3:FOXO1 expression in rhabdomyosarcoma is variable. PAX3:FOXO1 low cell states are characterized by more efficient adhesion, migration and tumor-propagating capacity.

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