Medical Research
- Fundamentals of vaping-associated pulmonary injury leading to severe respiratory distress
Vaping promotes pathological structural remodeling and functional impairment of the cardiopulmonary system in a mouse inhalation model. This model of vaping-associated pulmonary injury (VAPI) demonstrates potential health risks and provides mechanistic insights on cellular and molecular levels.
- Bimodal fibrosis in a novel mouse model of bleomycin-induced usual interstitial pneumonia
A novel mouse model of induced-usual interstitial pneumonia shows bimodal fibrosis with honeycombing, similar to chronic lung disease seen with idiopathic pulmonary fibrosis.
- Single-domain antibody screening by isPLA-seq
This study describes a high-sensitive, high-throughput single-domain antibody library screening approach, which is applicable for any given interested protein at single-cell resolution by isPLA-seq.
- Autoimmune anti-DNA and anti-phosphatidylserine antibodies predict development of severe COVID-19
COVID-19 induces high levels of autoimmune anti-DNA and anti-phosphatidylserine antibodies that are detected in some patients upon hospital admission and predict later development of severe disease.
- Serum proteomics reveals disorder of lipoprotein metabolism in sepsis
This study illustrated that lipoprotein and lipid metabolism might play a significant role in patients with sepsis and that complement activation was significantly enriched in patients with sepsis-associated encephalopathy.
- Improved systemic AAV gene therapy with a neurotrophic capsid in Niemann–Pick disease type C1 mice
This work highlights the importance of CNS transduction for treatment of neurological diseases, a finding with significant clinical implications considering the long-lasting effects of gene therapy.
- Negative correlation of single-cell PAX3:FOXO1 expression with tumorigenicity in rhabdomyosarcoma
Single-cell PAX3:FOXO1 expression in rhabdomyosarcoma is variable. PAX3:FOXO1 low cell states are characterized by more efficient adhesion, migration and tumor-propagating capacity.
- TPC2 promotes choroidal angiogenesis and inflammation in a mouse model of neovascular age-related macular degeneration
This study identifies the endolysosomal two-pore channel TPC2 as a potential novel drug target for age-related macular degeneration (AMD). Inhibition of TPC2 reduces two key clinical hallmarks of the AMD, retinal inflammation and formation of leaky choroi.
- Prognostic accuracy of MALDI-TOF mass spectrometric analysis of plasma in COVID-19
High mortality rate in SARS-CoV-2–infected individuals requires accurate markers for predicting COVID-19 severity. MALDI-TOF analysis revealed differential plasma levels of SAA1 and SAA2 associated with higher risk of hospitalization and can be used to improve COVID-19 monitoring and therapy.
- HCV poly U/UC sequence–induced inflammation leads to metabolic disorders in vulvar lichen sclerosis
Multi-omics analysis reveals the elevation of HCV poly U/UC sequences, which induces abnormal inflammation and related metabolic disorder in vulvar lichen sclerosis.