Medical Research
The L-NAME mouse model of preeclampsia and impact to long-term maternal cardiovascular healthThe L-NAME mouse model of preeclampsia mimics key aspects of disease in pregnancy, but does not demonstrate the increased long-term risk of cardiovascular disease seen in individuals following preeclampsia.
Measuring cystic fibrosis drug responses in organoids derived from 2D differentiated nasal epitheliaThis work describes an optimized assay to determine CFTR drug responses in people with cystic fibrosis, using nasal-airway organoids that are generated from 2D differentiated epithelial monolayers.
IgM-enriched immunoglobulin improves colistin efficacy in a pneumonia model by Pseudomonas aeruginosaUsing polyclonal IgM-enriched immunoglobulin (IgM-IG) as adjuvant therapy to colistin appears useful in the treatment of pneumonia caused by multidrug-resistant strains of P. aeruginosa.
Spatial proteomics finds CD155 and Endophilin-A1 as mediators of growth and invasion in medulloblastomaSpatial proteomics identifies MAP4K4 as a regulator of the plasma membrane-associated proteome and reveals CD155 and EndoA1 as mediators of proliferation and invasiveness in medulloblastoma cells.
Meflin-positive cancer-associated fibroblasts enhance tumor response to immune checkpoint blockadeMeflin/ISLR is the marker of a cancer-associated fibroblast subset that enhances tumor response to immune checkpoint blockade therapy.
Visualized procollagen Iα1 demonstrates the intracellular processing of propeptidesProcollagen Iα1 with two tags reveals the different fates of processed propeptides, the rate-limiting step in collagen secretion, and a link between defects in intracellular processing and diseases.
Topical TMPRSS2 inhibition prevents SARS-CoV-2 infection in differentiated human airway culturesThere is an urgent need to develop novel therapeutic strategies to prevent viral transmission and COVID-19 disease—we show that topical application of camostat, a TMPRSS2 inhibitor, could be a simple, safe, and effective strategy for restricting upper airway infection.
Preclinical and randomized phase I studies of plitidepsin in adults hospitalized with COVID-19This proof-of-concept study shows that plitidepsin, a marine peptide that inhibits SARS-CoV-2 replication, has a favorable safety profile and may be an efficacious treatment for patients with COVID-19.
Necrotic debris and STING exert therapeutically relevant effects on tumor cholesterol homeostasisNecrotic debris and STING affect tumor cell growth by altering cholesterol homeostasis in opposing manner, revealing that modulation of cellular cholesterol load may help control tumor growth.
β-arrestin1 promotes tauopathy by transducing GPCR signaling, disrupting microtubules and autophagyGPCRs regulator, β-arrestin1, is increased in FTLD-tau patients, is required for β2-adrenergic receptor and metabotropic glutamate receptor 2-induced tau phosphorylation, promotes tau aggregation by impairing autophagy, and destabilizes microtubule dynamics, whereas genetic reduction in β-arrestin1 mitigates tauopathy and cognitive impairments.