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Medical Research

  • iNKT cells coordinate immune pathways to enable engraftment in nonconditioned hosts
    Open Access
    iNKT cells coordinate immune pathways to enable engraftment in nonconditioned hosts

    Nicholas J Hess, Nikhila S Bharadwaj, Elizabeth A Bobeck, Courtney E McDougal, Shidong Ma, John-Demian Sauer, Amy W Hudson, Jenny E Gumperz

    Nicholas J Hess ... Jenny E Gumperz

    Published 10 June 2021

    Immunotherapeutic iNKT cells interact with monocytes and T cells in human umbilical cord blood grafts to simultaneously limit inflammation while promoting hematopoietic activity.

  • The transcriptional landscape analysis of basal cell carcinomas reveals novel signalling pathways and actionable targets
    Open Access
    The transcriptional landscape analysis of basal cell carcinomas reveals novel signalling pathways and actionable targets

    Ivan V Litvinov, Pingxing Xie, Scott Gunn, Denis Sasseville, Philippe Lefrançois

    Ivan V Litvinov ... Philippe Lefrançois

    Published 10 May 2021

    Basal cell carcinoma (BCC) is the most common skin cancer and human malignancy. By analyzing BCC RNA sequencing data according to clinically important features, we identified novel differentially regulated genes and new targetable pathways. Several biomarkers were validated in patient-derived BCC samples.

  • Urinary prostaglandin E2 as a biomarker for recurrent UTI in postmenopausal women
    Open Access
    Urinary prostaglandin E2 as a biomarker for recurrent UTI in postmenopausal women

    Tahmineh Ebrahimzadeh, Amy Kuprasertkul, Michael L Neugent, Kevin C Lutz, Jorge L Fuentes, Jashkaran Gadhvi, Fatima Khan, Cong Zhang, Belle M Sharon, Kim Orth, Qiwei Li, Philippe E Zimmern, Nicole J De Nisco

    Tahmineh Ebrahimzadeh ... Nicole J De Nisco

    Published 6 May 2021

    This work uses controlled human cohorts to investigate urinary prostaglandin E2, the product of cyclooxygenase-2, as both a diagnostic and prognostic biomarker of recurrent UTI postmenopausal women.

  • MALDI-IMS combined with shotgun proteomics identify and localize new factors in male infertility
    Open Access
    MALDI-IMS combined with shotgun proteomics identify and localize new factors in male infertility

    Shibojyoti Lahiri, Wasim Aftab, Lena Walenta, Leena Strauss, Matti Poutanen, Artur Mayerhofer, Axel Imhof

    Shibojyoti Lahiri ... Axel Imhof

    Published 6 January 2021

    In situ proteomics of male infertility.

  • Tissue-selective alternate promoters guide NLRP6 expression
    Open Access
    Tissue-selective alternate promoters guide NLRP6 expression

    Nathan A Bracey, Jaye M Platnich, Arthur Lau, Hyunjae Chung, M Eric Hyndman, Justin A MacDonald, Justin Chun, Paul L Beck, Stephen E Girardin, Paul MK Gordon, Daniel A Muruve

    Nathan A Bracey ... Daniel A Muruve

    Published 29 December 2020

    The NLRP6 innate immune sensor is regulated by tissue-selective alternate promoters that facilitate translational gene silencing outside of the intestinal epithelium in both humans and mice.

  • Genetic and stochastic influences upon tumor formation and tumor types in Li-Fraumeni mouse models
    Open Access
    Genetic and stochastic influences upon tumor formation and tumor types in Li-Fraumeni mouse models

    Chang S Chan, Yvonne Sun, Hua Ke, Yuhan Zhao, Merzu Belete, Cen Zhang, Zhaohui Feng, Arnold J Levine, Wenwei Hu

    Chang S Chan ... Wenwei Hu

    Published 29 December 2020

    This study used mice heterozygous for Tp53 mutations with different genetic backgrounds to investigate the genetic or stochastic factors that modify the penetrance of tumor formation by Tp53 mutation.

  • Profiling of immune dysfunction in COVID-19 patients allows early prediction of disease progression
    Open Access
    Profiling of immune dysfunction in COVID-19 patients allows early prediction of disease progression

    André F Rendeiro, Joseph Casano, Charles Kyriakos Vorkas, Harjot Singh, Ayana Morales, Robert A DeSimone, Grant B Ellsworth, Rosemary Soave, Shashi N Kapadia, Kohta Saito, Christopher D Brown, JingMei Hsu, Christopher Kyriakides, Steven Chiu, Luca Vincenzo Cappelli, Maria Teresa Cacciapuoti, Wayne Tam, Lorenzo Galluzzi, Paul D Simonson, Olivier Elemento, Mirella Salvatore, Giorgio Inghirami

    André F Rendeiro ... Giorgio Inghirami

    Published 24 December 2020

    Deep immune profiling of COVID-19 patients with different disease severity reveals populations associated with severe disease and can be used to predict disease severity early on.

  • Role of opioid signaling in kidney damage during the development of salt-induced hypertension
    Open Access
    Role of opioid signaling in kidney damage during the development of salt-induced hypertension

    Daria Golosova, Oleg Palygin, Ruslan Bohovyk, Christine A Klemens, Vladislav Levchenko, Denisha R Spires, Elena Isaeva, Ashraf El-Meanawy, Alexander Staruschenko

    Daria Golosova ... Alexander Staruschenko

    Published 12 October 2020

    Stimulation of kappa opioid receptors modulates calcium influx via TRPC6 channels in podocytes, which ultimately compromises the integrity of the glomerular filtration barrier and promotes a marked worsening of blood pressure control and renal damage.

  • Human G-MDSCs are neutrophils at distinct maturation stages promoting tumor growth in breast cancer
    Open Access
    Human G-MDSCs are neutrophils at distinct maturation stages promoting tumor growth in breast cancer

    Meliha Mehmeti-Ajradini, Caroline Bergenfelz, Anna-Maria Larsson, Robert Carlsson, Kristian Riesbeck, Jonas Ahl, Helena Janols, Marlene Wullt, Anders Bredberg, Eva Källberg, Frida Björk Gunnarsdottir, Camilla Rydberg Millrud, Lisa Rydén, Gesine Paul, Niklas Loman, Jörgen Adolfsson, Ana Carneiro, Karin Jirström, Fredrika Killander, Daniel Bexell, Karin Leandersson

    Meliha Mehmeti-Ajradini ... Karin Leandersson

    Published 21 September 2020

    This study shows that immunosuppressive primary breast cancer patient–derived G-MDSCs (PMN-MDSCs) are neutrophils at a range of maturations stages, and provides in vivo evidence for that human G-MDSCs also promote tumor growth and myeloid immune cell exclusion.

  • Multiplexed chemogenetics in astrocytes and motoneurons restore blood–spinal cord barrier in ALS
    Open Access
    Multiplexed chemogenetics in astrocytes and motoneurons restore blood–spinal cord barrier in ALS

    Najwa Ouali Alami, Linyun Tang, Diana Wiesner, Barbara Commisso, David Bayer, Jochen Weishaupt, Luc Dupuis, Phillip Wong, Bernd Baumann, Thomas Wirth, Tobias M Boeckers, Deniz Yilmazer-Hanke, Albert Ludolph, Francesco Roselli

    Najwa Ouali Alami ... Francesco Roselli

    Published 8 September 2020

    Chemogenetic motoneuron excitation and astrocyte GPCR-Gi signaling restore blood–spinal cord barrier, disrupted in four ALS mouse models, revealing its role in disease progression but not initiation.

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