Medical Research
Whole genome sequencing of drug resistance Mycobacterium tuberculosis from extra-pulmonary sitesThe article summarizes the characteristics of patients with drug resistance extra-pulmonary tuberculosis (DR-EPTB) and gene mutations of drug resistant Mycobacterium tuberculosis (DR-TB) from the patients with EPTB in a municipality of southwest China.
SF3B1 mutation–mediated sensitization to H3B-8800 splicing inhibitor in chronic lymphocytic leukemiaUnderstanding the pathogenic mechanisms of SF3B1 mutation can help unravel their contribution in patients’ worse prognosis. The cytotoxic effects and delayed leukemic infiltration induced by H3B-8800 support the potential use of SF3B1 inhibitors as a novel therapy in CLL.
Skewed X-inactivation is associated with retinal dystrophy in female carriers of RPGR mutationsThis study shows that skewed X-inactivation modulates the occurrence of Retinitis Pigmentosa in female carriers of RPGR mutations. The findings have implications towards therapeutic interventions.
Inhibition of protein arginine deiminase 4 prevents inflammation-mediated heart failure in arthritisInhibition of protein arginine deiminase 4 (PAD4), with an orally available inhibitor (JBI-589), prevents the development of hypertrophic cardiomyopathy and diastolic heart failure in murine inflammatory arthritis with reduced neutrophil infiltration, NET deposition, and biomarkers of thromboinflammation in the myocardium.
Reciprocal regulation between the molecular clock and kidney injuryThe work describes the crosstalk between the circadian rhythm and kidney damage in several mouse genetic models defining that the molecular clock component Cry is important to regulate inflammation, metabolism, and fibrosis.
B-cell targeting with anti-CD38 daratumumab: implications for differentiation and memory responsesDaratumumab is an anti-CD38–targeting antibody that depletes plasma cells. This study shows that daratumumab also disturbs humoral immune responses beyond depletion only and may be used as therapeutic in B cell–mediated autoimmune diseases.
Differential roles of FOXC2 in the trabecular meshwork and Schlemm’s canal in glaucomatous pathologyFOXC2 is required in the Schlemm’s canal endothelium and neural crest-derived trabecular meshwork cells for the morphogenesis and maintenance of Schlemm’s canal.
Inhibition of microRNA-33b in humanized mice ameliorates nonalcoholic steatohepatitisExperiments using humanized mice created by knocking in microRNA (miR)-33b into an intron of Srebf1 show that suppression of miR-33b by nucleic acid drugs is useful for the treatment of NASH.
Intranasal soluble ACE2 improves survival and prevents brain SARS-CoV-2 infectionA soluble ACE2 protein bioengineered to have extended duration of action and enhanced affinity for SARS-CoV-2 provides markedly improved survival and organ protection when administered intranasally. Reducing brain SARS-CoV-2 titers is an important determinant of therapeutic efficacy.
Cell death and barrier disruption by clinically used iodine concentrationsClinically used concentrations of povidone-iodine (PVP-I) are toxic to eukaryotic cells by attacking the lipid bilayer and tight junctions with fast kinetics and urge the reappraisal of PVP-I use.