Medical Research
- Disease- and sex-specific differences in patients with heart valve disease: a proteome study
Proteomics provide novel insights into molecular mechanisms and cardiac remodeling in heart failure because of pressure overload in aortic valve stenosis and volume overload in mitral valve regurgitation.
- Mutation-agnostic RNA interference with engineered replacement rescues Tmc1-related hearing loss
Mutation-agnostic RNA interference with concomitant, knockdown-resistant gene replacement, results in robust auditory brainstem response and cochlear hair cell preservation in the murine model of TMC1-related autosomal dominant hearing loss.
- Kindlin2 enables EphB/ephrinB bi-directional signaling to support vascular development
Kindlin2 supports EphB4/ephrinB2 bi-directional signaling functions by associating with a highly conserved NIYY motif in the ephrinB2 cytoplasmic tail to promote ephrinB2 clustering and EphB4 activation, thereby enabling arteriovenous segregation during embryonic development.
- Transcriptome analyses in infertile men reveal germ cell–specific expression and splicing patterns
We uncover extensive germ cell type–dependent transcriptome changes in human spermatogenesis and demonstrate the potential of alternative splicing in the regulation of spermatogenesis.
- Tanshinone functions as a coenzyme that confers gain of function of NQO1 to suppress ferroptosis
NQO1 catalyzes the reduction of tanshinones to detoxify lipid peroxyl radicals and inhibit ferroptosis both in vitro and in vivo, providing a molecular mechanism for the therapeutic effects of tanshinones, such as cardiac protection.
- A prediction model for COVID-19 liver dysfunction in patients with normal hepatic biochemical parameters
The composite model of sex and the novel protein marker ANGL3 exhibits great potential in predicting the risk of developing LD in COVID-19 patients with normal hepatic biochemical parameters on admission.
- Mitochondrial stress-induced GFRAL signaling controls diurnal food intake and anxiety-like behavior
Muscle mitochondrial stress signals to the brain via hindbrain-specific GFRAL receptor signaling to promote hypothalamic CRH induction, which associates with GFRAL-dependent modulation of systemic energy metabolism, diurnal food intake, and anxiety-like behavior.
- Islet Gene View—a tool to facilitate islet research
Islet Gene View (IGW) is a web resource that makes information on gene expression in human islets from donors easily accessible to the scientific community. The relationship of global RNA expression from 188 donor-islets with islet phenotypes is explored.
- The L-NAME mouse model of preeclampsia and impact to long-term maternal cardiovascular health
The L-NAME mouse model of preeclampsia mimics key aspects of disease in pregnancy, but does not demonstrate the increased long-term risk of cardiovascular disease seen in individuals following preeclampsia.
- Measuring cystic fibrosis drug responses in organoids derived from 2D differentiated nasal epithelia
This work describes an optimized assay to determine CFTR drug responses in people with cystic fibrosis, using nasal-airway organoids that are generated from 2D differentiated epithelial monolayers.