Medical Research
MALDI-IMS combined with shotgun proteomics identify and localize new factors in male infertilityIn situ proteomics of male infertility.
Tissue-selective alternate promoters guide NLRP6 expressionThe NLRP6 innate immune sensor is regulated by tissue-selective alternate promoters that facilitate translational gene silencing outside of the intestinal epithelium in both humans and mice.
Genetic and stochastic influences upon tumor formation and tumor types in Li-Fraumeni mouse modelsThis study used mice heterozygous for Tp53 mutations with different genetic backgrounds to investigate the genetic or stochastic factors that modify the penetrance of tumor formation by Tp53 mutation.
Profiling of immune dysfunction in COVID-19 patients allows early prediction of disease progressionDeep immune profiling of COVID-19 patients with different disease severity reveals populations associated with severe disease and can be used to predict disease severity early on.
Role of opioid signaling in kidney damage during the development of salt-induced hypertensionStimulation of kappa opioid receptors modulates calcium influx via TRPC6 channels in podocytes, which ultimately compromises the integrity of the glomerular filtration barrier and promotes a marked worsening of blood pressure control and renal damage.
Human G-MDSCs are neutrophils at distinct maturation stages promoting tumor growth in breast cancerThis study shows that immunosuppressive primary breast cancer patient–derived G-MDSCs (PMN-MDSCs) are neutrophils at a range of maturations stages, and provides in vivo evidence for that human G-MDSCs also promote tumor growth and myeloid immune cell exclusion.
Multiplexed chemogenetics in astrocytes and motoneurons restore blood–spinal cord barrier in ALSChemogenetic motoneuron excitation and astrocyte GPCR-Gi signaling restore blood–spinal cord barrier, disrupted in four ALS mouse models, revealing its role in disease progression but not initiation.
Mitochondrial spongiotic brain disease: astrocytic stress and harmful rapamycin and ketosis effectAstrocyte-specific mtDNA depletion causes spongiotic encephalopathy, aggravated by ketogenic diet or rapamycin. Astrocytes, but not neurons, drive mitochondrial integrated stress response in the CNS.
BH4 activates CaMKK2 and rescues the cardiomyopathic phenotype in rodent models of diabetesThis study reports that BH4 activates CaMKK2/PGC-1α; signaling pathway and has a therapeutic effect on diabetic cardiomyopathy.
Loss of polycystins suppresses deciliation via the activation of the centrosomal integrity pathwayDeletion of the polycystins activates components of the centrosomal integrity pathway, resulting in delayed cell deciliation and prolonged activation of cilia-related signaling pathways.