Skip to main content
Advertisement

Main menu

  • Home
  • Articles
    • Newest Articles
    • Current Issue
    • Methods & Resources
    • Archive
    • Subjects
  • Collections
  • Submit
    • Submit a Manuscript
    • Author Guidelines
    • License, Copyright, Fee
    • FAQ
    • Why Submit
  • About
    • About Us
    • Editors & Staff
    • Board Members
    • Licensing and Reuse
    • Reviewer Guidelines
    • Privacy Policy
    • Advertise
    • Contact Us
    • LSA LLC
  • Alerts
  • Other Publications
    • EMBO Press
    • The EMBO Journal
    • EMBO reports
    • EMBO Molecular Medicine
    • Molecular Systems Biology
    • Rockefeller University Press
    • Journal of Cell Biology
    • Journal of Experimental Medicine
    • Journal of General Physiology
    • Cold Spring Harbor Laboratory Press
    • Genes & Development
    • Genome Research

User menu

  • My alerts

Search

  • Advanced search
Life Science Alliance
  • Other Publications
    • EMBO Press
    • The EMBO Journal
    • EMBO reports
    • EMBO Molecular Medicine
    • Molecular Systems Biology
    • Rockefeller University Press
    • Journal of Cell Biology
    • Journal of Experimental Medicine
    • Journal of General Physiology
    • Cold Spring Harbor Laboratory Press
    • Genes & Development
    • Genome Research
  • My alerts
Life Science Alliance

Advanced Search

  • Home
  • Articles
    • Newest Articles
    • Current Issue
    • Methods & Resources
    • Archive
    • Subjects
  • Collections
  • Submit
    • Submit a Manuscript
    • Author Guidelines
    • License, Copyright, Fee
    • FAQ
    • Why Submit
  • About
    • About Us
    • Editors & Staff
    • Board Members
    • Licensing and Reuse
    • Reviewer Guidelines
    • Privacy Policy
    • Advertise
    • Contact Us
    • LSA LLC
  • Alerts
  • Follow lsa Template on Twitter

Medical Research

  • Spatial proteomics finds CD155 and Endophilin-A1 as mediators of growth and invasion in medulloblastoma
    Open Access
    Spatial proteomics finds CD155 and Endophilin-A1 as mediators of growth and invasion in medulloblastoma

    Charles Capdeville, Linda Russo, David Penton, Jessica Migliavacca, Milica Zecevic, Alexandre Gries, Stephan CF Neuhauss, Michael A Grotzer, Martin Baumgartner

    Charles Capdeville ... Martin Baumgartner

    Published 16 March 2022

    Spatial proteomics identifies MAP4K4 as a regulator of the plasma membrane-associated proteome and reveals CD155 and EndoA1 as mediators of proliferation and invasiveness in medulloblastoma cells.

  • Meflin-positive cancer-associated fibroblasts enhance tumor response to immune checkpoint blockade
    Open Access
    Meflin-positive cancer-associated fibroblasts enhance tumor response to immune checkpoint blockade

    Yuki Miyai, Daisuke Sugiyama, Tetsunari Hase, Naoya Asai, Tetsuro Taki, Kazuki Nishida, Takayuki Fukui, Toyofumi Fengshi Chen-Yoshikawa, Hiroki Kobayashi, Shinji Mii, Yukihiro Shiraki, Yoshinori Hasegawa, Hiroyoshi Nishikawa, Yuichi Ando, Masahide Takahashi, Atsushi Enomoto

    Yuki Miyai ... Atsushi Enomoto

    Published 2 March 2022

    Meflin/ISLR is the marker of a cancer-associated fibroblast subset that enhances tumor response to immune checkpoint blockade therapy.

  • Visualized procollagen Iα1 demonstrates the intracellular processing of propeptides
    Open Access
    Visualized procollagen Iα1 demonstrates the intracellular processing of propeptides

    Toshiaki Tanaka, Koji Moriya, Makoto Tsunenaga, Takayo Yanagawa, Hiromi Morita, Takashi Minowa, Yoh-ichi Tagawa, Nobutaka Hanagata, Yutaka Inagaki, Toshiyuki Ikoma

    Toshiaki Tanaka ... Toshiyuki Ikoma

    Published 18 February 2022

    Procollagen Iα1 with two tags reveals the different fates of processed propeptides, the rate-limiting step in collagen secretion, and a link between defects in intracellular processing and diseases.

  • Topical TMPRSS2 inhibition prevents SARS-CoV-2 infection in differentiated human airway cultures
    Open Access
    Topical TMPRSS2 inhibition prevents SARS-CoV-2 infection in differentiated human airway cultures

    Wenrui Guo, Linsey M Porter, Thomas WM Crozier, Matthew Coates, Akhilesh Jha, Mikel McKie, James A Nathan, Paul J Lehner, Edward JD Greenwood, Frank McCaughan

    Wenrui Guo ... Frank McCaughan

    Published 2 February 2022

    There is an urgent need to develop novel therapeutic strategies to prevent viral transmission and COVID-19 disease—we show that topical application of camostat, a TMPRSS2 inhibitor, could be a simple, safe, and effective strategy for restricting upper airway infection.

  • Preclinical and randomized phase I studies of plitidepsin in adults hospitalized with COVID-19
    Open Access
    Preclinical and randomized phase I studies of plitidepsin in adults hospitalized with COVID-19

    Jose F Varona, Pedro Landete, Jose A Lopez-Martin, Vicente Estrada, Roger Paredes, Pablo Guisado-Vasco, Lucia Fernandez de Orueta, Miguel Torralba, Jesus Fortun, Roberto Vates, Jose Barberan, Bonaventura Clotet, Julio Ancochea, Daniel Carnevali, Noemi Cabello, Lourdes Porras, Paloma Gijon, Alfonso Monereo, Daniel Abad, Sonia Zuñiga, Isabel Sola, Jordi Rodon, Julia Vergara-Alert, Nuria Izquierdo-Useros, Salvador Fudio, Maria Jose Pontes, Beatriz de Rivas, Patricia Giron de Velasco, Antonio Nieto, Javier Gomez, Pablo Aviles, Rubin Lubomirov, Alvaro Belgrano, Belen Sopesen, Kris M White, Romel Rosales, Soner Yildiz, Ann-Kathrin Reuschl, Lucy G Thorne, Clare Jolly, Greg J Towers, Lorena Zuliani-Alvarez, Mehdi Bouhaddou, Kirsten Obernier, Briana L McGovern, M Luis Rodriguez, Luis Enjuanes, Jose M Fernandez-Sousa, Nevan J Krogan, Jose M Jimeno, Adolfo Garcia-Sastre

    Jose F Varona ... Adolfo Garcia-Sastre

    Published 10 January 2022

    This proof-of-concept study shows that plitidepsin, a marine peptide that inhibits SARS-CoV-2 replication, has a favorable safety profile and may be an efficacious treatment for patients with COVID-19.

  • Necrotic debris and STING exert therapeutically relevant effects on tumor cholesterol homeostasis
    Open Access
    Necrotic debris and STING exert therapeutically relevant effects on tumor cholesterol homeostasis

    Sampath Katakam, Santosh Anand, Patricia Martin, Nicolo Riggi, Ivan Stamenkovic

    Sampath Katakam ... Ivan Stamenkovic

    Published 4 January 2022

    Necrotic debris and STING affect tumor cell growth by altering cholesterol homeostasis in opposing manner, revealing that modulation of cellular cholesterol load may help control tumor growth.

  • β-arrestin1 promotes tauopathy by transducing GPCR signaling, disrupting microtubules and autophagy
    Open Access
    β-arrestin1 promotes tauopathy by transducing GPCR signaling, disrupting microtubules and autophagy

    Jung-AA Woo, Yan Yan, Teresa R Kee, Sara Cazzaro, Kyle C McGill Percy, Xinming Wang, Tian Liu, Stephen B Liggett, David E Kang

    Jung-AA Woo ... David E Kang

    Published 3 December 2021

    GPCRs regulator, β-arrestin1, is increased in FTLD-tau patients, is required for β2-adrenergic receptor and metabotropic glutamate receptor 2-induced tau phosphorylation, promotes tau aggregation by impairing autophagy, and destabilizes microtubule dynamics, whereas genetic reduction in β-arrestin1 mitigates tauopathy and cognitive impairments.

  • Bis-choline tetrathiomolybdate prevents copper-induced blood–brain barrier damage
    Open Access
    Bis-choline tetrathiomolybdate prevents copper-induced blood–brain barrier damage

    Sabine Borchard, Stefanie Raschke, Krzysztof M Zak, Carola Eberhagen, Claudia Einer, Elisabeth Weber, Sandra M Müller, Bernhard Michalke, Josef Lichtmannegger, Albrecht Wieser, Tamara Rieder, Grzegorz M Popowicz, Jerzy Adamski, Martin Klingenspor, Andrew H Coles, Ruth Viana, Mikkel H Vendelbo, Thomas D Sandahl, Tanja Schwerdtle, Thomas Plitz, Hans Zischka

    Sabine Borchard ... Hans Zischka

    Published 2 December 2021

    The blood–brain barrier endothelial cell monolayer becomes permeable to elevated copper loosely bound to albumin, which can be avoided by a high-affinity copper chelator but not by D-penicillamine.

  • Transcriptomics reveals immune-metabolism disorder in acute-on-chronic liver failure in rats
    Open Access
    Transcriptomics reveals immune-metabolism disorder in acute-on-chronic liver failure in rats

    Hozeifa M Hassan, Qun Cai, Xi Liang, Jiaojiao Xin, Keke Ren, Jing Jiang, Dongyan Shi, Yingyan Lu, Tan Li, Yuxin Shang, Lulu He, Xi Chen, Suwan Sun, Peng Li, Beibei Guo, Jiaxian Chen, Hui Yang, Wen Hu, Xin Chen, Jun Li

    Hozeifa M Hassan ... Jun Li

    Published 1 December 2021

    Liver tissue transcriptomics of liver cirrhosis (LC)–based acute-on-chronic liver failure (ACLF) rats reveal immune-metabolism disorder as the core mechanism underlying ACLF development and prognosis.

  • Fundamentals of vaping-associated pulmonary injury leading to severe respiratory distress
    Open Access
    Fundamentals of vaping-associated pulmonary injury leading to severe respiratory distress

    Carolina Esquer, Oscar Echeagaray, Fareheh Firouzi, Clarissa Savko, Grant Shain, Pria Bose, Abigail Rieder, Sophie Rokaw, Andrea Witon-Paulo, Natalie Gude, Mark A Sussman

    Carolina Esquer ... Mark A Sussman

    Published 22 November 2021

    Vaping promotes pathological structural remodeling and functional impairment of the cardiopulmonary system in a mouse inhalation model. This model of vaping-associated pulmonary injury (VAPI) demonstrates potential health risks and provides mechanistic insights on cellular and molecular levels.

Pages

  • Next
  • 1
  • 2
  • 3
  • 4
  • 5
  • 6
  • Aging (16)
  • Biophysics (19)
  • Cancer (119)
  • Cell Biology (255)
  • Chemical Biology (10)
  • Chromatin & Epigenetics (59)
  • Development (41)
  • Ecology (3)
  • Evolution (22)
  • Genetics, Gene Therapy & Genetic Disease (57)
  • Genomics & Functional Genomics (84)
  • Immunology (101)
  • Medical Research (54)
  • Metabolism (42)
  • Methods & Resources (36)
  • Microbiology, Virology & Host Pathogen Interaction (85)
  • Molecular Biology (157)
  • Molecular Diagnostics & Diagnostic Imaging (7)
  • Neuroscience (60)
  • Pharmacology & Biotechnology (11)
  • Physiology (16)
  • Plant Science (15)
  • Stem Cells (40)
  • Structural Biology (37)
  • Synthetic Biology (2)
  • Systems & Computational Biology (64)
Advertisement

EMBO Press LogoRockefeller University Press LogoCold Spring Harbor Logo

Content

  • Home
  • Newest Articles
  • Current Issue
  • Archive
  • Subject Collections

For Authors

  • Submit a Manuscript
  • Author Guidelines
  • License, copyright, Fee

Other Services

  • Alerts
  • Twitter
  • RSS Feeds

More Information

  • Editors & Staff
  • Reviewer Guidelines
  • Feedback
  • Licensing and Reuse
  • Privacy Policy

ISSN: 2575-1077
© 2023 Life Science Alliance LLC

Life Science Alliance is registered as a trademark in the U.S. Patent and Trade Mark Office and in the European Union Intellectual Property Office.