Medical Research
Rapid ER remodeling induced by a peptide–lipid complex in dying tumor cellsAlpha1-oleate induces novel ER remodeling, causing peripheral ER loss, vesiculation, and nuclear entry, expanding the nuclear ER with its content of dying cell debris.
Nef mediates neuroimmune response, myelin impairment, and neuronal injury in EcoHIV-infected miceAntiretroviral therapy (ART) has improved HIV-associated neurocognitive disorder (HAND) outcomes, but nearly half of individuals remain affected. This study reveals how the HIV protein Nef drives neuroinflammation and neuronal damage, highlighting potential therapeutic targets for HAND-related neuropathology.
SLMAP3 is essential for neurulation through mechanisms involving cytoskeletal elements, ABP, and PCPUsing knockout mice, the study shows that SLMAP3 is important for neural tube development through mechanisms that regulate planar cell polarity and the cytoskeleton.
Ccrk-Mak/Ick signaling is a ciliary transport regulator essential for retinal photoreceptor survivalThis study shows that the ciliopathy kinases Mak and Ick cooperatively act as ciliary tip-localized IFT regulators that are phosphorylated and activated by Ccrk in retinal photoreceptor cells.
Enhancing uterine receptivity for embryo implantation through controlled collagenase interventionA safe and effective enzymatic pretreatment in mice enhances embryo implantation, revealing how remodeling of specific matrix components of the uterus facilitates implantation through distinct molecular mechanisms without any risk, holding clinical potential for supporting medical treatments in human reproduction.
Neutrophil-avid nanocarrier uptake by STAT3 dominant-negative hyper-IgE syndrome patient neutrophilsRecurrent infections are a hallmark of STAT3 DN hyper-IgE syndrome, a rare immunodeficiency syndrome, and our study suggests that neutrophil-avid nanocarriers have potential for directed delivery of cargo therapeutics to improve neutrophil infection clearance in these patients.
Defective Integrator activity shapes the transcriptome of patients with multiple sclerosisHigh-depth RNA sequencing reveals down-regulation of HP1α/CBX5 in monocytes of multiple sclerosis patients, associated with major transcriptomic changes and reduced activity of the Integrator complex.
Activation of the Keap1/Nrf2 pathway suppresses mitochondrial dysfunction, oxidative stress, and motor phenotypes in C9orf72 ALS/FTD modelsC9orf72 mutations cause multiple mitochondrial disruptions, but only genetically boosting antioxidant expression rescued motor deficits in vivo, supporting a pathogenic connection. Genetic or pharmacological activation of the Keap1/Nrf2 pathway ameliorated pathological phenotypes in Drosophila models and patient-derived iNeurons.
Single-housing–induced islet epigenomic changes are related to polymorphisms in diabetic KK miceThis study demonstrates that non-coding variants in KK mice, a polygenic model of type 2 diabetes, may be involved in the development of diabetes via epigenetic mechanisms during social isolation.
Full-length MSP1 is a major target of protective immunity after controlled human malaria infectionFull-length merozoite surface protein 1 is an important target of functional antibodies that play an important role in clinical immunity against invasive asexual Plasmodium falciparum parasites.