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Medical Research

  • Rapid ER remodeling induced by a peptide–lipid complex in dying tumor cells
    Open Access
    Rapid ER remodeling induced by a peptide–lipid complex in dying tumor cells

    Samudra Sabari, Siddharth Chinchankar, Ines Ambite, Atefeh Nazari, António Pedro NBM Carneiro, Axel Svenningsson, Catharina Svanborg, Arunima Chaudhuri

    Samudra Sabari ... Arunima Chaudhuri

    Published 25 March 2025

    Alpha1-oleate induces novel ER remodeling, causing peripheral ER loss, vesiculation, and nuclear entry, expanding the nuclear ER with its content of dying cell debris.

  • Nef mediates neuroimmune response, myelin impairment, and neuronal injury in EcoHIV-infected mice
    Open Access
    Nef mediates neuroimmune response, myelin impairment, and neuronal injury in EcoHIV-infected mice

    Jessica K Schenck, Cheryl Clarkson-Paredes, Tatiana Pushkarsky, Yongsen Wang, Robert H Miller, Michael I Bukrinsky

    Jessica K Schenck ... Michael I Bukrinsky

    Published 12 November 2024

    Antiretroviral therapy (ART) has improved HIV-associated neurocognitive disorder (HAND) outcomes, but nearly half of individuals remain affected. This study reveals how the HIV protein Nef drives neuroinflammation and neuronal damage, highlighting potential therapeutic targets for HAND-related neuropathology.

  • SLMAP3 is essential for neurulation through mechanisms involving cytoskeletal elements, ABP, and PCP
    Open Access
    SLMAP3 is essential for neurulation through mechanisms involving cytoskeletal elements, ABP, and PCP

    Taha Rehmani, Ana Paula Dias, Billi Dawn Applin, Maysoon Salih, Balwant S Tuana

    Taha Rehmani ... Balwant S Tuana

    Published 4 October 2024

    Using knockout mice, the study shows that SLMAP3 is important for neural tube development through mechanisms that regulate planar cell polarity and the cytoskeleton.

  • Ccrk-Mak/Ick signaling is a ciliary transport regulator essential for retinal photoreceptor survival
    Open Access
    Ccrk-Mak/Ick signaling is a ciliary transport regulator essential for retinal photoreceptor survival

    Taro Chaya, Yamato Maeda, Ryotaro Tsutsumi, Makoto Ando, Yujie Ma, Naoko Kajimura, Teruyuki Tanaka, Takahisa Furukawa

    Taro Chaya ... Takahisa Furukawa

    Published 18 September 2024

    This study shows that the ciliopathy kinases Mak and Ick cooperatively act as ciliary tip-localized IFT regulators that are phosphorylated and activated by Ccrk in retinal photoreceptor cells.

  • Enhancing uterine receptivity for embryo implantation through controlled collagenase intervention
    Open Access
    Enhancing uterine receptivity for embryo implantation through controlled collagenase intervention

    Eldar Zehorai, Tamar Gross Lev, Elee Shimshoni, Ron Hadas, Idan Adir, Ofra Golani, Guillaume Molodij, Ram Eitan, Karl E Kadler, Orit Kollet, Michal Neeman, Nava Dekel, Inna Solomonov, Irit Sagi

    Eldar Zehorai ... Irit Sagi

    Published 16 August 2024

    A safe and effective enzymatic pretreatment in mice enhances embryo implantation, revealing how remodeling of specific matrix components of the uterus facilitates implantation through distinct molecular mechanisms without any risk, holding clinical potential for supporting medical treatments in human reproduction.

  • Neutrophil-avid nanocarrier uptake by STAT3 dominant-negative hyper-IgE syndrome patient neutrophils
    Open Access
    Neutrophil-avid nanocarrier uptake by STAT3 dominant-negative hyper-IgE syndrome patient neutrophils

    Kathryn M Rubey, Alexandra Freeman, Alexander R Mukhitov, Andrew J Paris, Susan M Lin, Ryan Rue, Hossein Fazelinia, Lynn A Spruce, Jennifer Roof, Jacob S Brenner, Jennifer Heimall, Vera P Krymskaya

    Kathryn M Rubey ... Vera P Krymskaya

    Published 12 August 2024

    Recurrent infections are a hallmark of STAT3 DN hyper-IgE syndrome, a rare immunodeficiency syndrome, and our study suggests that neutrophil-avid nanocarriers have potential for directed delivery of cargo therapeutics to improve neutrophil infection clearance in these patients.

  • Defective Integrator activity shapes the transcriptome of patients with multiple sclerosis
    Open Access
    Defective Integrator activity shapes the transcriptome of patients with multiple sclerosis

    Yevheniia Porozhan, Mikkel Carstensen, Sandrine Thouroude, Mickael Costallat, Christophe Rachez, Eric Batsché, Thor Petersen, Tove Christensen, Christian Muchardt

    Yevheniia Porozhan ... Christian Muchardt

    Published 19 July 2024

    High-depth RNA sequencing reveals down-regulation of HP1α/CBX5 in monocytes of multiple sclerosis patients, associated with major transcriptomic changes and reduced activity of the Integrator complex.

  • Activation of the Keap1/Nrf2 pathway suppresses mitochondrial dysfunction, oxidative stress, and motor phenotypes in <em>C9orf72</em> ALS/FTD models
    Open Access
    Activation of the Keap1/Nrf2 pathway suppresses mitochondrial dysfunction, oxidative stress, and motor phenotypes in C9orf72 ALS/FTD models

    Wing Hei Au, Leonor Miller-Fleming, Alvaro Sanchez-Martinez, James AK Lee, Madeleine J Twyning, Hiran A Prag, Laura Raik, Scott P Allen, Pamela J Shaw, Laura Ferraiuolo, Heather Mortiboys, Alexander J Whitworth

    Wing Hei Au ... Alexander J Whitworth

    Published 21 June 2024

    C9orf72 mutations cause multiple mitochondrial disruptions, but only genetically boosting antioxidant expression rescued motor deficits in vivo, supporting a pathogenic connection. Genetic or pharmacological activation of the Keap1/Nrf2 pathway ameliorated pathological phenotypes in Drosophila models and patient-derived iNeurons.

  • Single-housing–induced islet epigenomic changes are related to polymorphisms in diabetic KK mice
    Open Access
    Single-housing–induced islet epigenomic changes are related to polymorphisms in diabetic KK mice

    Takao Nammo, Nobuaki Funahashi, Haruhide Udagawa, Junji Kozawa, Kenta Nakano, Yukiko Shimizu, Tadashi Okamura, Miho Kawaguchi, Takashi Uebanso, Wataru Nishimura, Masaki Hiramoto, Iichiro Shimomura, Kazuki Yasuda

    Takao Nammo ... Kazuki Yasuda

    Published 14 June 2024

    This study demonstrates that non-coding variants in KK mice, a polygenic model of type 2 diabetes, may be involved in the development of diabetes via epigenetic mechanisms during social isolation.

  • Full-length MSP1 is a major target of protective immunity after controlled human malaria infection
    Open Access
    Full-length MSP1 is a major target of protective immunity after controlled human malaria infection

    Micha Rosenkranz, Irene N Nkumama, Rodney Ogwang, Sara Kraker, Marie Blickling, Kennedy Mwai, Dennis Odera, James Tuju, Kristin Fürle, Roland Frank, Emily Chepsat, Melissa C Kapulu, CHMI-SIKA Study Team, Faith HA Osier

    Micha Rosenkranz ... Faith HA Osier

    Published 20 May 2024

    Full-length merozoite surface protein 1 is an important target of functional antibodies that play an important role in clinical immunity against invasive asexual Plasmodium falciparum parasites.

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