Medical Research
Spatial proteomics finds CD155 and Endophilin-A1 as mediators of growth and invasion in medulloblastomaSpatial proteomics identifies MAP4K4 as a regulator of the plasma membrane-associated proteome and reveals CD155 and EndoA1 as mediators of proliferation and invasiveness in medulloblastoma cells.
Meflin-positive cancer-associated fibroblasts enhance tumor response to immune checkpoint blockadeMeflin/ISLR is the marker of a cancer-associated fibroblast subset that enhances tumor response to immune checkpoint blockade therapy.
Visualized procollagen Iα1 demonstrates the intracellular processing of propeptidesProcollagen Iα1 with two tags reveals the different fates of processed propeptides, the rate-limiting step in collagen secretion, and a link between defects in intracellular processing and diseases.
Topical TMPRSS2 inhibition prevents SARS-CoV-2 infection in differentiated human airway culturesThere is an urgent need to develop novel therapeutic strategies to prevent viral transmission and COVID-19 disease—we show that topical application of camostat, a TMPRSS2 inhibitor, could be a simple, safe, and effective strategy for restricting upper airway infection.
Preclinical and randomized phase I studies of plitidepsin in adults hospitalized with COVID-19This proof-of-concept study shows that plitidepsin, a marine peptide that inhibits SARS-CoV-2 replication, has a favorable safety profile and may be an efficacious treatment for patients with COVID-19.
Necrotic debris and STING exert therapeutically relevant effects on tumor cholesterol homeostasisNecrotic debris and STING affect tumor cell growth by altering cholesterol homeostasis in opposing manner, revealing that modulation of cellular cholesterol load may help control tumor growth.
β-arrestin1 promotes tauopathy by transducing GPCR signaling, disrupting microtubules and autophagyGPCRs regulator, β-arrestin1, is increased in FTLD-tau patients, is required for β2-adrenergic receptor and metabotropic glutamate receptor 2-induced tau phosphorylation, promotes tau aggregation by impairing autophagy, and destabilizes microtubule dynamics, whereas genetic reduction in β-arrestin1 mitigates tauopathy and cognitive impairments.
Bis-choline tetrathiomolybdate prevents copper-induced blood–brain barrier damageThe blood–brain barrier endothelial cell monolayer becomes permeable to elevated copper loosely bound to albumin, which can be avoided by a high-affinity copper chelator but not by D-penicillamine.
Transcriptomics reveals immune-metabolism disorder in acute-on-chronic liver failure in ratsLiver tissue transcriptomics of liver cirrhosis (LC)–based acute-on-chronic liver failure (ACLF) rats reveal immune-metabolism disorder as the core mechanism underlying ACLF development and prognosis.
Fundamentals of vaping-associated pulmonary injury leading to severe respiratory distressVaping promotes pathological structural remodeling and functional impairment of the cardiopulmonary system in a mouse inhalation model. This model of vaping-associated pulmonary injury (VAPI) demonstrates potential health risks and provides mechanistic insights on cellular and molecular levels.