Strange as it may seem: the many links between Wnt signaling, planar cell polarity, and cilia
- 1Howard Hughes Medical Institute, Section of Molecular Cell and Developmental Biology, Institute for Cellular and Molecular Biology, University of Texas, Austin, Texas 78712, USA;
- 2Department of Cell and Molecular Biology, Feinberg School of Medicine, Northwestern University, Chicago, Illinois 60611, USA
Abstract
Cilia are important cellular structures that have been implicated in a variety of signaling cascades. In this review, we discuss the current evidence for and against a link between cilia and both the canonical Wnt/β-catenin pathway and the noncanonical Wnt/planar cell polarity (PCP) pathway. Furthermore, we address the evidence implicating a role for PCP components in ciliogenesis. Given the lack of consensus in the field, we use new data on the control of ciliary protein localization as a basis for proposing new models by which cell type-specific regulation of ciliary components via differential transport, regulated entry and exit, or diffusion barriers might generate context-dependent functions for cilia.
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↵3 Corresponding author.
E-MAIL wallingford{at}mail.utexas.edu; FAX (512) 471-3878.
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Article is online at http://www.genesdev.org/cgi/doi/10.1101/gad.2008011.
- Copyright © 2011 by Cold Spring Harbor Laboratory Press
Freely available online through the Genes & Development Open Access option.