[HTML][HTML] Alveolar Organoids in Lung Disease Modeling

E Purev, K Bahmed, B Kosmider - Biomolecules, 2024 - mdpi.com
Lung organoids display a tissue-specific functional phenomenon and mimic the features of
the original organ. They can reflect the properties of the cells, such as morphology, polarity …

Advanced lung organoids for respiratory system and pulmonary disease modeling

H Joo, S Min, SW Cho - Journal of Tissue Engineering, 2024 - journals.sagepub.com
Amidst the recent coronavirus disease 2019 (COVID-19) pandemic, respiratory system
research has made remarkable progress, particularly focusing on infectious diseases. Lung …

[HTML][HTML] Modelling bronchial epithelial-fibroblast cross-talk in idiopathic pulmonary fibrosis (IPF) using a human-derived in vitro air liquid interface (ALI) culture

SL Barron, O Wyatt, A O'Connor, D Mansfield… - Scientific Reports, 2024 - nature.com
Abstract Idiopathic Pulmonary Fibrosis (IPF) is a devastating form of respiratory disease with
a life expectancy of 3–4 years. Inflammation, epithelial injury and myofibroblast proliferation …

[HTML][HTML] Functional Pdgfra fibroblast heterogeneity in normal and fibrotic mouse lung

CS Trempus, BN Papas, MI Sifre, CD Bortner… - JCI insight, 2023 - ncbi.nlm.nih.gov
Aberrant fibroblast function plays a key role in the pathogenesis of idiopathic pulmonary
fibrosis, a devastating disease of unrelenting extracellular matrix deposition in response to …

[HTML][HTML] Human Pluripotent Stem Cell-Derived Alveolar Organoids: Cellular Heterogeneity and Maturity

J Jung, SR Yang, WJ Kim, CK Rhee… - Tuberculosis and …, 2024 - ncbi.nlm.nih.gov
Chronic respiratory diseases such as idiopathic pulmonary fibrosis, chronic obstructive
pulmonary disease, and respiratory infections injure the alveoli; the damage evoked is …

Translational mapping of spatially resolved transcriptomes in human and mouse pulmonary fibrosis

L Franzén, M Olsson Lindvall, M Hühn, V Ptasinski… - bioRxiv, 2023 - biorxiv.org
Idiopathic pulmonary fibrosis (IPF) is a progressive lung disease with poor prognosis and
limited treatment options. Efforts to identify effective treatments are thwarted by limited …

[PDF][PDF] Alveolar Progenitor Cells in Lung Damage and Regeneration in Pulmonary Fibrosis

V Ptasinski - 2023 - portal.research.lu.se
The lung is a vital organ in the body enabling us to breathe. During chronic lung diseases,
the function of the lung is impacted by damage to the tissue structure. Idiopathic pulmonary …

Lung epithelial progenitor responses in diseased micro-environments

R Kortekaas - 2024 - research.rug.nl
Idiopathic pulmonary fibrosis (IPF) and chronic obstructive lung disease (COPD) are both
incurable lung diseases that worsen over time. The epithelium, which lines the inner surface …