Background Interferon-gamma (IFNγ) exerts potent growth inhibitory effects on a wide range
of cancer cells through unknown signaling pathways. We pursued complementary screening …

In-frame BRAF exon 12 deletions are increasingly identified in various tumor types. The
resultant BRAFΔβ3-αC oncoproteins usually lack five amino acids in the β3-αC helix linker …

At least 40% of human cancers are associated with aberrant ERK pathway activity (ERKp).
Inhibitors targeting various effectors within the ERKp have been developed and explored for …

Despite significant advances in targeted therapies against the hyperactivated
BRAFV600/MEK pathway for patients with unresectable metastatic melanoma, acquired …

CD8+ T cells play essential roles in antitumor and antiviral immune responses. The term T-
cell exhaustion was initially used to describe the functionally exhaustive phenotype of T cells …

Cancers with acquired resistance to targeted therapy can become simultaneously
dependent on the presence of the targeted therapy drug for survival, suggesting that …

Background Upregulation of the mitogen-activated protein kinase (MAPK) cascade is
common in hepatocellular carcinoma (HCC). Neuroblastoma RAS viral oncogene homolog …

Résumé Cette thèse explore la régulation de la voie RAS-MAPK dans l'adénocarcinome
pulmonaire, où des altérations génétiques favorisent la progression tumorale en …

Elevated phosphoinositide 3-kinase (PI3K) activity in human tumors has prompted
widespread efforts to develop chemical PI3K inhibitors for oncology indications. In an …