[PDF][PDF] AAV genome modification for efficient AAV production
The adeno-associated virus (AAV) is one of the most potent vectors in gene therapy. The
experimental profile of this vector shows its efficiency and accepted safety, which explains its …
experimental profile of this vector shows its efficiency and accepted safety, which explains its …
[HTML][HTML] Lighting the way: recent developments and applications in molecular optogenetics
A Armbruster, AME Mohamed, HT Phan… - Current opinion in …, 2024 - Elsevier
Highlights•New optogenetic switches open new new control modalities.•Optogenetics foster
advances in bioprocess engineering, biomedicine, and materials.•Optogenetics as interface …
advances in bioprocess engineering, biomedicine, and materials.•Optogenetics as interface …
[HTML][HTML] Spread of activation and interaction between channels with multi-channel optogenetic stimulation in the mouse cochlea
For individuals with severe to profound hearing loss resulting from irreversibly damaged hair
cells, cochlear implants can be used to restore hearing by delivering electrical stimulation …
cells, cochlear implants can be used to restore hearing by delivering electrical stimulation …
[HTML][HTML] Channelrhodopsin fluorescent tag replacement for clinical translation of optogenetic hearing restoration
Sensory restoration by optogenetic neurostimulation provides a promising future alternative
to current electrical stimulation approaches. So far, channelrhodopsins (ChRs) typically …
to current electrical stimulation approaches. So far, channelrhodopsins (ChRs) typically …
Is there an unmet medical need for improved hearing restoration?
Hearing impairment, the most prevalent sensory deficit, affects more than 466 million people
worldwide (WHO). We presently lack causative treatment for the most common form …
worldwide (WHO). We presently lack causative treatment for the most common form …
[HTML][HTML] Patient perspectives on the need for improved hearing rehabilitation: A qualitative survey study of German cochlear implant users
V Hunniford, R Kühler, B Wolf, D Keppeler… - Frontiers in …, 2023 - frontiersin.org
Background The electrical cochlear implant (eCI) partially restores hearing in individuals
affected by profound hearing impairment (HI) or deafness. However, the limited resolution of …
affected by profound hearing impairment (HI) or deafness. However, the limited resolution of …
[PDF][PDF] En route to sound coding strategy for optical cochlear implants
L Khurana, T Harczos, T Moser, L Jablonski - Iscience, 2023 - cell.com
In 2019, disabling hearing loss affected 430 million people worldwide and will reach over
700 million by 2050. Severe-to-complete sensorineural hearing loss is often treated by …
700 million by 2050. Severe-to-complete sensorineural hearing loss is often treated by …
Longitudinal optogenetic mapping reveals enhanced motor control by the contralesional cortex after traumatic brain injury in mice
F Yang, F Wang, X Ma, M Zhou, S Jiang, W Xu - Experimental Neurology, 2023 - Elsevier
Traumatic brain injury (TBI) is a significant cause of human disability, and understanding its
spontaneous recovery pattern after injury is critical for potential treatments. However, studies …
spontaneous recovery pattern after injury is critical for potential treatments. However, studies …
AAV genome modification for efficient AAV production
W Asaad, P Volos, D Maksimov, E Khavina, A Deviatkin… - europepmc.org
The adeno-associated virus (AAV) is one of the most potent vectors in gene therapy. The
experimental profile of this vector shows its efficiency and accepted safety, which explains its …
experimental profile of this vector shows its efficiency and accepted safety, which explains its …