Cellular quality control systems have gained much attention in recent decades. Among
these, autophagy is a natural self-preservation mechanism that continuously eliminates toxic …

Maintaining mitochondrial homeostasis is a potential therapeutic strategy for various
diseases, including neurodegenerative diseases, cardiovascular diseases, metabolic …

Mitochondria and peroxisomes are closely related metabolic organelles, both in terms of
origin and in terms of function. Mitochondria and peroxisomes can also be turned over by …

Mutations in SNCA, the gene encoding α-synuclein (αSyn), cause familial Parkinson's
disease (PD) and aberrant αSyn is a key pathological hallmark of idiopathic PD. This α …

Ubiquitin-specific protease 30 (USP30) is a deubiquitinating enzyme (DUB) belonging to the
USP subfamily, which was found localized in the mitochondrial outer membrane and …

Mitochondrial dysfunction is implicated in Parkinson disease (PD). Mutations in Parkin, an
E3 ubiquitin ligase, can cause juvenile-onset Parkinsonism, probably through impairment of …

Ubiquitination refers to the conjugation of the ubiquitin protein (a small protein highly
conserved among eukaryotes) to itself or to other proteins through differential use of …

Parkinson's disease (PD) is a neurodegenerative disorder that has been associated with
mitochondrial dysfunction, oxidative stress, and defects in mitophagy as well as α-synuclein …

Mechanisms that prevent accidental activation of the PINK1/Parkin mitophagy circuit on
healthy mitochondria are poorly understood. On the surface of damaged mitochondria …

Parkinson's disease (PD) is the most common neurodegenerative movement disorder.
There are no available therapeutics that slow or halt the progressive loss of dopamine …