Ceramides are a heterogeneous group of bioactive membrane sphingolipids that play
specialized regulatory roles in cellular metabolism depending on their characteristic fatty …

Neurodegenerative Diseases (NDDs) are a group of disorders that cause progressive
deficits of neuronal function. Recent evidence argues that sphingolipid metabolism is …

Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disease that affects
motor neurons. Mutations in the SPTLC1 subunit of serine palmitoyltransferase (SPT), which …

The single mitochondrion of Toxoplasma gondii is highly dynamic, being predominantly in a
peripherally distributed lasso-shape in intracellular parasites and collapsed in extracellular …

Mitochondria interact with the ER at structurally and functionally specialized membrane
contact sites known as mitochondria–ER contact sites (MERCs). Combining proximity …

The emergence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has
triggered a global pandemic, which severely endangers public health. Our and others' works …

Lipotoxicity arises from the accumulation of lipid intermediates in non-adipose tissue,
precipitating cellular dysfunction and death. Ceramide, a toxic byproduct of excessive free …

Abstract In late November 2019, Prof. Lina M. Obeid passed away from cancer, a disease
she spent her life researching and studying its intricate molecular underpinnings. Along with …

In eukaryotes, the de novo synthesis of sphingolipids (SLs) consists of multiple sequential
steps which are compartmentalized between the endoplasmic reticulum and the Golgi …

Metabolic pathways are complex and intertwined. Deficiencies in one or more enzymes in a
given pathway are directly linked with genetic diseases, most of them having devastating …