[HTML][HTML] Metabolic alterations upon SARS-CoV-2 infection and potential therapeutic targets against coronavirus infection
Abstract The coronavirus disease 2019 (COVID-19) caused by coronavirus SARS-CoV-2
infection has become a global pandemic due to the high viral transmissibility and …
infection has become a global pandemic due to the high viral transmissibility and …
Recent Progress in the Development of Opaganib for the Treatment of Covid-19
CD Smith, LW Maines, SN Keller… - Drug Design …, 2023 - Taylor & Francis
The Covid-19 pandemic driven by the SARS-CoV-2 virus continues to exert extensive
humanitarian and economic stress across the world. Although antivirals active against mild …
humanitarian and economic stress across the world. Although antivirals active against mild …
[HTML][HTML] A global lipid map reveals host dependency factors conserved across SARS-CoV-2 variants
A comprehensive understanding of host dependency factors for SARS-CoV-2 remains
elusive. Here, we map alterations in host lipids following SARS-CoV-2 infection using …
elusive. Here, we map alterations in host lipids following SARS-CoV-2 infection using …
[HTML][HTML] Integrated multi-omics analyses identify anti-viral host factors and pathways controlling SARS-CoV-2 infection
Host anti-viral factors are essential for controlling SARS-CoV-2 infection but remain largely
unknown due to the biases of previous large-scale studies toward pro-viral host factors. To …
unknown due to the biases of previous large-scale studies toward pro-viral host factors. To …
[HTML][HTML] Integrative plasma metabolic and lipidomic modelling of SARS-CoV-2 Infection in relation to clinical severity and early mortality prediction
An integrative multi-modal metabolic phenotyping model was developed to assess the
systemic plasma sequelae of SARS-CoV-2 (rRT-PCR positive) induced COVID-19 disease …
systemic plasma sequelae of SARS-CoV-2 (rRT-PCR positive) induced COVID-19 disease …
[HTML][HTML] Targeting the complement–sphingolipid system in COVID-19 and gaucher diseases: evidence for a new treatment strategy
VS Trivedi, AF Magnusen, R Rani, L Marsili… - International Journal of …, 2022 - mdpi.com
Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2)-induced disease
(COVID-19) and Gaucher disease (GD) exhibit upregulation of complement 5a (C5a) and its …
(COVID-19) and Gaucher disease (GD) exhibit upregulation of complement 5a (C5a) and its …
Antiviral activity of glucosylceramide synthase inhibitors in alphavirus infection of the central nervous system
R Avraham, S Melamed, H Achdout, N Erez… - Brain …, 2023 - academic.oup.com
Virus-induced CNS diseases impose a considerable human health burden worldwide. For
many viral CNS infections, neither antiviral drugs nor vaccines are available. In this study …
many viral CNS infections, neither antiviral drugs nor vaccines are available. In this study …
[HTML][HTML] Metatranscriptomic analysis revealed Prevotella as a potential biomarker of oropharyngeal microbiomes in SARS-CoV-2 infection
S Lu, Y Zhou, Y Hu, J Wang, H Li, Y Lin… - Frontiers in Cellular …, 2023 - frontiersin.org
Background and Objectives: Disease severity and prognosis of coronavirus disease 2019
(COVID-19), and other respiratory viral infections, can be affected by the oropharyngeal …
(COVID-19), and other respiratory viral infections, can be affected by the oropharyngeal …
SARS‐CoV‐2 ORF3a expression in brain disrupts the autophagy–lysosomal pathway, impairs sphingolipid homeostasis, and drives neuropathogenesis
Severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) infection causes injury to
multiple organ systems, including the brain. SARS‐CoV‐2's neuropathological mechanisms …
multiple organ systems, including the brain. SARS‐CoV‐2's neuropathological mechanisms …
Cerebrospinal fluid metabolomic and proteomic characterization of neurologic post-acute sequelae of SARS-CoV-2 infection
S Chen, J Liang, D Chen, Q Huang, K Sun… - Brain, Behavior, and …, 2024 - Elsevier
The mechanism by which SARS-CoV-2 causes neurological post-acute sequelae of SARS-
CoV-2 (neuro-PASC) remains unclear. Herein, we conducted proteomic and metabolomic …
CoV-2 (neuro-PASC) remains unclear. Herein, we conducted proteomic and metabolomic …