Advances and utility of the human plasma proteome

EW Deutsch, GS Omenn, Z Sun, M Maes… - Journal of proteome …, 2021 - ACS Publications
The study of proteins circulating in blood offers tremendous opportunities to diagnose,
stratify, or possibly prevent diseases. With recent technological advances and the urgent …

Mass spectrometry‐based high‐throughput proteomics and its role in biomedical studies and systems biology

CB Messner, V Demichev, Z Wang, J Hartl… - …, 2023 - Wiley Online Library
There are multiple reasons why the next generation of biological and medical studies
require increasing numbers of samples. Biological systems are dynamic, and the effect of a …

[HTML][HTML] Proteomics of fibrin amyloid microclots in long COVID/post-acute sequelae of COVID-19 (PASC) shows many entrapped pro-inflammatory molecules that may …

A Kruger, M Vlok, S Turner, C Venter… - Cardiovascular …, 2022 - Springer
Background Post-acute sequelae of COVID-19 (PASC), also now known as long COVID,
has become a major global health and economic burden. Previously, we provided evidence …

High‐resolution serum proteome trajectories in COVID‐19 reveal patient‐specific seroconversion

PE Geyer, FM Arend, S Doll, ML Louiset… - EMBO molecular …, 2021 - embopress.org
A deeper understanding of COVID‐19 on human molecular pathophysiology is urgently
needed as a foundation for the discovery of new biomarkers and therapeutic targets. Here …

[HTML][HTML] Early prediction of COVID-19 patient survival by targeted plasma multi-omics and machine learning

VR Richard, C Gaither, R Popp, D Chaplygina… - Molecular & Cellular …, 2022 - ASBMB
The recent surge of coronavirus disease 2019 (COVID-19) hospitalizations severely
challenges healthcare systems around the globe and has increased the demand for reliable …

[HTML][HTML] A proteomic survival predictor for COVID-19 patients in intensive care

V Demichev, P Tober-Lau, T Nazarenko… - PLOS Digital …, 2022 - journals.plos.org
Global healthcare systems are challenged by the COVID-19 pandemic. There is a need to
optimize allocation of treatment and resources in intensive care, as clinically established risk …

[HTML][HTML] The impact of severe COVID-19 on plasma antioxidants

N Žarković, A Jastrząb, I Jarocka-Karpowicz… - Molecules, 2022 - mdpi.com
Several studies suggested the association of COVID-19 with systemic oxidative stress, in
particular with lipid peroxidation and vascular stress. Therefore, this study aimed to evaluate …

[HTML][HTML] Characterization by quantitative serum proteomics of immune-related prognostic biomarkers for COVID-19 symptomatology

M Villar, JM Urra, FJ Rodríguez-del-Río… - Frontiers in …, 2021 - frontiersin.org
The COVID-19 pandemic caused by SARS-CoV-2 challenges the understanding of factors
affecting disease progression and severity. The identification of prognostic biomarkers and …

CD5L is a canonical component of circulatory IgM

N Oskam, MA den Boer, MV Lukassen… - Proceedings of the …, 2023 - National Acad Sciences
Immunoglobulin M (IgM) is an evolutionary conserved key component of humoral immunity,
and the first antibody isotype to emerge during an immune response. IgM is a large (1 MDa) …

Plasma biomarkers for systemic inflammation in COVID‐19 survivors

J Zhao, M Schank, L Wang, X Dang… - PROTEOMICS …, 2022 - Wiley Online Library
Background While the majority of COVID‐19 patients fully recover from the infection and
become asymptomatic, a significant proportion of COVID‐19 survivors experience a broad …