Advances and utility of the human plasma proteome
The study of proteins circulating in blood offers tremendous opportunities to diagnose,
stratify, or possibly prevent diseases. With recent technological advances and the urgent …
stratify, or possibly prevent diseases. With recent technological advances and the urgent …
Mass spectrometry‐based high‐throughput proteomics and its role in biomedical studies and systems biology
There are multiple reasons why the next generation of biological and medical studies
require increasing numbers of samples. Biological systems are dynamic, and the effect of a …
require increasing numbers of samples. Biological systems are dynamic, and the effect of a …
[HTML][HTML] Proteomics of fibrin amyloid microclots in long COVID/post-acute sequelae of COVID-19 (PASC) shows many entrapped pro-inflammatory molecules that may …
A Kruger, M Vlok, S Turner, C Venter… - Cardiovascular …, 2022 - Springer
Background Post-acute sequelae of COVID-19 (PASC), also now known as long COVID,
has become a major global health and economic burden. Previously, we provided evidence …
has become a major global health and economic burden. Previously, we provided evidence …
High‐resolution serum proteome trajectories in COVID‐19 reveal patient‐specific seroconversion
A deeper understanding of COVID‐19 on human molecular pathophysiology is urgently
needed as a foundation for the discovery of new biomarkers and therapeutic targets. Here …
needed as a foundation for the discovery of new biomarkers and therapeutic targets. Here …
[HTML][HTML] Early prediction of COVID-19 patient survival by targeted plasma multi-omics and machine learning
VR Richard, C Gaither, R Popp, D Chaplygina… - Molecular & Cellular …, 2022 - ASBMB
The recent surge of coronavirus disease 2019 (COVID-19) hospitalizations severely
challenges healthcare systems around the globe and has increased the demand for reliable …
challenges healthcare systems around the globe and has increased the demand for reliable …
[HTML][HTML] A proteomic survival predictor for COVID-19 patients in intensive care
V Demichev, P Tober-Lau, T Nazarenko… - PLOS Digital …, 2022 - journals.plos.org
Global healthcare systems are challenged by the COVID-19 pandemic. There is a need to
optimize allocation of treatment and resources in intensive care, as clinically established risk …
optimize allocation of treatment and resources in intensive care, as clinically established risk …
[HTML][HTML] The impact of severe COVID-19 on plasma antioxidants
N Žarković, A Jastrząb, I Jarocka-Karpowicz… - Molecules, 2022 - mdpi.com
Several studies suggested the association of COVID-19 with systemic oxidative stress, in
particular with lipid peroxidation and vascular stress. Therefore, this study aimed to evaluate …
particular with lipid peroxidation and vascular stress. Therefore, this study aimed to evaluate …
[HTML][HTML] Characterization by quantitative serum proteomics of immune-related prognostic biomarkers for COVID-19 symptomatology
The COVID-19 pandemic caused by SARS-CoV-2 challenges the understanding of factors
affecting disease progression and severity. The identification of prognostic biomarkers and …
affecting disease progression and severity. The identification of prognostic biomarkers and …
CD5L is a canonical component of circulatory IgM
N Oskam, MA den Boer, MV Lukassen… - Proceedings of the …, 2023 - National Acad Sciences
Immunoglobulin M (IgM) is an evolutionary conserved key component of humoral immunity,
and the first antibody isotype to emerge during an immune response. IgM is a large (1 MDa) …
and the first antibody isotype to emerge during an immune response. IgM is a large (1 MDa) …
Plasma biomarkers for systemic inflammation in COVID‐19 survivors
Background While the majority of COVID‐19 patients fully recover from the infection and
become asymptomatic, a significant proportion of COVID‐19 survivors experience a broad …
become asymptomatic, a significant proportion of COVID‐19 survivors experience a broad …