Cancer is the leading cause of death worldwide, and its treatment and outcomes have been
dramatically revolutionised by targeted therapies. As the most frequently mutated oncogene …

Intercellular communication is a key feature of cancer progression and metastasis.
Extracellular vesicles (EVs) are generated by all cells, including cancer cells, and recent …

Rationale: A cell-specific delivery vehicle is required to achieve gene editing of the disease-
associated cells, so the hereditable genome editing reactions are confined within these cells …

Cell-derived exosomes have opened new horizons in modern therapy for advanced drug
delivery and therapeutic applications, due to their key features such as low immunogenicity …

Undruggable proteins are a class of proteins that are often characterized by large, complex
structures or functions that are difficult to interfere with using conventional drug design …

The recently described role of RNA methylation in regulating immune cell infiltration into
tumors has attracted interest, given its potential impact on immunotherapy response …

RISPR-Cas9 has exhibited enormous potential in gene therapy. It can perform genome
editing with single-nucleotide precision in various types of cell and tissue, providing a …

Genome editing technology has emerged as a potential therapeutic tool for treating
incurable diseases. In particular, the discovery of clustered regularly interspaced short …

Extracellular vesicles (EVs) are transport vesicles secreted by living cells and released into
the extracellular environment. Recent studies have shown that EVs serve as “messengers” …

Extracellular vesicles (EVs) function as a mode of intercellular communication and
molecular transfer to elicit diverse biological/functional response. Accumulating evidence …