[HTML][HTML] Neuronal endolysosomal transport and lysosomal functionality in maintaining axonostasis
JC Roney, XT Cheng, ZH Sheng - Journal of Cell Biology, 2022 - rupress.org
Lysosomes serve as degradation hubs for the turnover of endocytic and autophagic cargos,
which is essential for neuron function and survival. Deficits in lysosome function result in …
which is essential for neuron function and survival. Deficits in lysosome function result in …
[HTML][HTML] Microtubule depolymerization contributes to spontaneous neurotransmitter release in vitro
CD Velasco, R Santarella-Mellwig, M Schorb… - Communications …, 2023 - nature.com
Microtubules are key to multiple neuronal functions involving the transport of organelles,
however, their relationship to neurotransmitter release is still unresolved. Here, we show that …
however, their relationship to neurotransmitter release is still unresolved. Here, we show that …
Transport-dependent maturation of organelles in neurons
A Mathew, SP Koushika - Current Opinion in Cell Biology, 2022 - Elsevier
Some organelles show a spatial gradient of maturation along the neuronal process where
more mature organelles are found closer to the cell body. This gradient is set up by …
more mature organelles are found closer to the cell body. This gradient is set up by …
Axonal transport of lysosomes in glucocerebrosidase-deficient iPSC-derived neurons
A Keefe - 2022 - summit.sfu.ca
Lysosomes are acidic organelles that traffic throughout neurons delivering catabolic
enzymes to distal regions of the cell and maintaining degradative demands. Loss of function …
enzymes to distal regions of the cell and maintaining degradative demands. Loss of function …