[HTML][HTML] More than meets the eye: The role of microglia in healthy and diseased retina
E Murenu, MJ Gerhardt, M Biel… - Frontiers in …, 2022 - frontiersin.org
Microglia are the main resident immune cells of the nervous system and as such they are
involved in multiple roles ranging from tissue homeostasis to response to insults and circuit …
involved in multiple roles ranging from tissue homeostasis to response to insults and circuit …
[HTML][HTML] Electrophysiology of endolysosomal two-pore channels: A current account
Two-pore channels TPC1 and TPC2 are ubiquitously expressed pathophysiologically
relevant proteins that reside on endolysosomal vesicles. Here, we review the …
relevant proteins that reside on endolysosomal vesicles. Here, we review the …
[HTML][HTML] Endolysosomal cation channels point the way towards precision medicine of cancer and infectious diseases
CC Chen, E Krogsaeter, CY Kuo, MC Huang… - Biomedicine & …, 2022 - Elsevier
Infectious diseases and cancer are among the key medical challenges that humankind is
facing today. A growing amount of evidence suggests that ion channels in the …
facing today. A growing amount of evidence suggests that ion channels in the …
Two-pore channels: going with the flows
AJ Morgan, LL Martucci, LC Davis… - Biochemical Society …, 2022 - portlandpress.com
In recent years, our understanding of the structure, mechanisms and functions of the endo-
lysosomal TPC (two-pore channel) family have grown apace. Gated by the second …
lysosomal TPC (two-pore channel) family have grown apace. Gated by the second …
[HTML][HTML] The protein biosynthesis inhibitor vioprolide A evokes anti-angiogenic and pro-survival actions by targeting NOP14 and decreasing VEGF receptor 2-and TAZ …
LD Burgers, Y Li, S Michalakis, S Ciurus… - Biomedicine & …, 2022 - Elsevier
Angiogenesis contributes to the progression of several diseases including cancer or age-
related macular degeneration and is crucially driven by pathologically hyperactive …
related macular degeneration and is crucially driven by pathologically hyperactive …
[HTML][HTML] Optical profiling of autonomous Ca2+ nanodomains generated by lysosomal TPC2 and TRPML1
LC Davis, AJ Morgan, A Galione - Cell Calcium, 2023 - Elsevier
Multiple families of Ca 2+-permeable channels co-exist on lysosomal Ca 2+ stores but how
each family couples to its own unique downstream physiology is unclear. We have therefore …
each family couples to its own unique downstream physiology is unclear. We have therefore …
[HTML][HTML] Targeting the two-pore channel 2 in cancer progression and metastasis
KA Skelding, DL Barry, DZ Theron… - Exploration of Targeted …, 2022 - ncbi.nlm.nih.gov
The importance of Ca 2+ signaling, and particularly Ca 2+ channels, in key events of cancer
cell function such as proliferation, metastasis, autophagy and angiogenesis, has recently …
cell function such as proliferation, metastasis, autophagy and angiogenesis, has recently …
[HTML][HTML] Blood Transcriptome Analysis of Beef Cow with Different Parity Revealed Candidate Genes and Gene Networks Regulating the Postpartum Diseases
Y Yang, C Chang, B Baiyin, Z Liu, L Guo, L Zhou, B Liu… - Genes, 2022 - mdpi.com
Maternal parity is an important physiological factor influencing beef cow reproductive
performance. However, there are few studies on the influence of different calving periods on …
performance. However, there are few studies on the influence of different calving periods on …
[HTML][HTML] Loss of two-pore channel 2 function in melanoma-derived tumours reduces tumour growth in vivo but greatly increases tumour-related toxicity in the organism
A Hanbashi, M Alotaibi, HMA Sobeai, L Binobaid… - Cancer Cell …, 2023 - Springer
Background Melanoma, a severe form of skin cancer, poses significant health risks due to its
aggressive nature and potential for metastasis. The role of two-pore channel 2 (TPC2) in the …
aggressive nature and potential for metastasis. The role of two-pore channel 2 (TPC2) in the …
Electrophysiological Techniques on the Study of Endolysosomal Ion Channels
CC Chen - Endolysosomal Voltage-Dependent Cation Channels, 2023 - Springer
Endolysosomal ion channels are a group of ion channel proteins that are functionally
expressed on the membrane of endolysosomal vesicles. The electrophysiological properties …
expressed on the membrane of endolysosomal vesicles. The electrophysiological properties …