Regulation of PRKN-independent mitophagy

P Terešak, A Lapao, N Subic, P Boya, Z Elazar… - Autophagy, 2022 - Taylor & Francis
Mitochondria are dynamic, multifunctional cellular organelles that play a fundamental role in
maintaining cellular homeostasis. Keeping the quality of mitochondria in check is of …

[HTML][HTML] The mitophagy pathway and its implications in human diseases

S Wang, H Long, L Hou, B Feng, Z Ma, Y Wu… - … and Targeted Therapy, 2023 - nature.com
Mitochondria are dynamic organelles with multiple functions. They participate in necrotic cell
death and programmed apoptotic, and are crucial for cell metabolism and survival …

PGAM5-mediated PHB2 dephosphorylation contributes to diabetic cardiomyopathy by disrupting mitochondrial quality surveillance

R Zou, J Tao, J He, C Wang, S Tan, Y Xia, X Chang… - Research, 2022 - spj.science.org
Disruption of the mitochondrial quality surveillance (MQS) system contributes to
mitochondrial dysfunction in diabetic cardiomyopathy (DCM). In this study, we observed that …

[HTML][HTML] Essential protein PHB2 and its regulatory mechanisms in cancer

A Qi, L Lamont, E Liu, SD Murray, X Meng, S Yang - Cells, 2023 - mdpi.com
Prohibitins (PHBs) are a highly conserved class of proteins and have an essential role in
transcription, epigenetic regulation, nuclear signaling, mitochondrial structural integrity, cell …

Age‐dependent integrity of the meiotic spindle assembly checkpoint in females requires Aurora kinase B

CS Blengini, AL Nguyen, M Aboelenain… - Aging Cell, 2021 - Wiley Online Library
A hallmark of advanced maternal age is a significant increase in meiotic chromosome
segregation errors, resulting in early miscarriages and congenital disorders. These errors …

[HTML][HTML] Aurora kinase A/AURKA functionally interacts with the mitochondrial ATP synthase to regulate energy metabolism and cell death

RK Sharma, A Chafik, G Bertolin - Cell Death Discovery, 2023 - nature.com
Cancer cells often hijack metabolic pathways to obtain the energy required to sustain their
proliferation. Understanding the molecular mechanisms underlying cancer cell metabolism …

[HTML][HTML] To eat or not to eat mitochondria? How do host cells cope with mitophagy upon bacterial infection?

J Verbeke, X De Bolle, T Arnould - Plos Pathogens, 2023 - journals.plos.org
Mitochondria fulfil a plethora of cellular functions ranging from energy production to
regulation of inflammation and cell death control. The fundamental role of mitochondria …

Identification of PHB2 as a potential biomarker of luminal A breast Cancer cells using a cell-specific aptamer

M Liu, Z Wang, S Li, Y Deng, N He - ACS Applied Materials & …, 2022 - ACS Publications
Precise diagnosis of breast cancer molecular subtypes remains a great challenge in clinics.
The present molecular biomarkers are not specific enough to classify breast cancer …

[HTML][HTML] Pgam5-mediated PHB2 dephosphorylation contributes to endotoxemia-induced myocardial dysfunction by inhibiting mitophagy and the mitochondrial …

C Cai, Z Li, Z Zheng, Z Guo, Q Li, S Deng… - … Journal of Biological …, 2023 - ncbi.nlm.nih.gov
Numerous mitochondrial abnormalities are reported to result from excessive inflammation
during endotoxemia. Prohibitin 2 (PHB2) and phosphoglycerate mutase 5 (Pgam5) have …

[HTML][HTML] Dual-specificity phosphatase 1 interacts with prohibitin 2 to improve mitochondrial quality control against type-3 cardiorenal syndrome

N Liu, Y Ding, H Zhou, X Chang… - International Journal of …, 2024 - ncbi.nlm.nih.gov
Abstract Type-3 cardiorenal syndrome (CRS-3) is acute kidney injury followed by cardiac
injury/dysfunction. Mitochondrial injury may impair myocardial function during CRS-3. Since …