Macrophages serve as bidirectional regulators and potential therapeutic targets for liver fibrosis
W Liang, X Huang, J Shi - Cell Biochemistry and Biophysics, 2023 - Springer
Liver fibrosis is a dynamic pathological process in which the structure and function of the
liver abnormally change due to long-term complex inflammatory reactions and chronic liver …
liver abnormally change due to long-term complex inflammatory reactions and chronic liver …
Relaxin in hepatic fibrosis: What is known and where to head?
D Ezhilarasan - Biochimie, 2021 - Elsevier
Relaxin (RLX) is a heterodimeric, polypeptide hormone that has natural anti-fibrotic activity
in many organs. During the chronic liver injury, hepatic stellate cells (HSCs) are …
in many organs. During the chronic liver injury, hepatic stellate cells (HSCs) are …
[HTML][HTML] Targeting GPR65 alleviates hepatic inflammation and fibrosis by suppressing the JNK and NF-κB pathways
K Zhang, MX Zhang, XX Meng, J Zhu, JJ Wang… - Military Medical …, 2023 - Springer
Background G-protein coupled receptors (GPCRs) are recognized as attractive targets for
drug therapy. However, it remains poorly understood how GPCRs, except for a few …
drug therapy. However, it remains poorly understood how GPCRs, except for a few …
[HTML][HTML] SKIL/SnoN attenuates TGF-β1/SMAD signaling-dependent collagen synthesis in hepatic fibrosis
C Chi, X Liang, T Cui, X Gao, R Liu… - Biomolecules and …, 2023 - ncbi.nlm.nih.gov
The ski-related novel protein N (SnoN), encoded by the SKIL gene, has been shown to
negatively regulate transforming growth factor-β1 (TGF-β1) signaling pathway. However, the …
negatively regulate transforming growth factor-β1 (TGF-β1) signaling pathway. However, the …