Head and neck cancer (HNC) is malignant, genetically complex and difficult to treat and is
the sixth most frequent cancer, with tobacco, alcohol and human papillomavirus being major …

The mitogen-activating protein kinase (MAPK) pathway is central for cell proliferation,
differentiation, and senescence. In human, germline defects of the pathway contribute to …

Oral cancer is a sub-category of head and neck cancers that primarily initiates in the oral
cavity. The primary treatment option for oral cancer remains surgery but it is associated with …

Background Although the mitogen-activated protein kinases (MAPK) pathway is hyperactive
in head and neck cancer (HNC), inhibition of MEK1/2 in HNC patients has not shown …

The tumor microenvironment (TME) within mucosal neoplastic tissue in oral cancer (ORCA)
is greatly influenced by tumor-infiltrating lymphocytes (TILs). Here, a clustering method was …

Blocking the mitogen‐activated protein kinase (MAPK) pathway with the MEK1/2 inhibitor
trametinib has produced promising results in patients with head and neck squamous cell …

Abstract Background PD-1/PD-L1 inhibitors have brought remarkable benefits but can cause
profound immune-related adverse events (irAEs). The host immunogenetic background is …

Immunotherapy has evolved into a powerful tool in the fight against a number of types of
cancer, including head and neck squamous cell carcinomas (HNSCC). Although checkpoint …

Simple Summary The aim of the present review was to summarize our studies on the
signaling pathways in cancer types that are involved in the development of oral cancer and …

The study is to explore the role of ferroptosis-related genes (FRGs) in the occurrence and
development of gastric cancer (GC), and to construct a new prognosis signature to predict …